Zhong, Y., et. al., Co-administration of of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment. International Journal of Nanomedicine, 2019, 14: 8543–8560. | Cancer, Colorectal Cancer | Nanoparticle (NP) therapeutic delivery for colorectal cancer: | FLI | Mouse | Lago X | 1-Shan Liu, and 2-Hao Yang, 1-Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China, 2-West China Hospital, Sichuan University, Chengdu, China | 2019 | | Nanoparticle (NP) therapeutic delivery for colorectal cancer: Tumor targeting of Paclitaxel (PTX)-loaded PLGA nanoparticles (PLGA-PTX) was enhanced by co-administered iRGD. Note: iRGD is a bifunctional peptide ligand containing a tumor-homing motif (RGD) and a tissue-penetrating motif (CendR). Once bound to tumor-associated iRGD sites, binding to CendR enhances tumor membrane permeability, elevating NP transport across membrane., Probe: DiD | cancer colorectal-cancer | nanoparticle-np-therapeutic-delivery-for-colorectal-cancer |
Zhong, Q., et. al., Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters, Biomaterials, June 2020, 206: 73-86. | Therapeutic Drug Delivery | Ultrasound-activated drug-loaded nanoemulsions | FLI | Rat | Lago | Raag Airan, Stanford University, Stanford, CA, USA | 2020 | | Ultrasound-activated drug-loaded nanoemulsions: Chemistries determined and a generalized production platform developed for polymeric perfluorocarbon nanoemulsions designed to cage a wide array of hydrophobic drugs, released by ultrasound signal, with a high potential for clinical translation, Probe: IR 800 | therapeutic-drug-delivery | ultrasound-activated-drug-loaded-nanoemulsions |
Zeiderman, M.R., et. al., Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2016, 2(7), 1108–1120. | Cancer, Pancreatic Cancer | Pancreatic tumor detection and treatment with novel theranostic particles | FLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2016 | | Pancreatic tumor detection and treatment with novel theranostic particles: Authors developed an acidic pH-targeted, chitosan capped, mesoporous silica (MS), gold nanorods (MS-GNRs) as both a tumor-targeting and drug-delivering nanoparticle (NP), with a NIR signals for sensitive optoacoustic (OA) imaging. Details on NP structure: MS protected the GNRs from thermal deformation, enhanced GNR thermal stability, and increased OA signal. Tumor-specific release of test therapeutic, gemcitabine, was mediated by two NP "gate keepers:" chitosan and a variant 7 of low pH insertion proteins (V7-LpHIPs), where chitosan and V7-LpHIP changed conformation in the presence of tumor micro enviroment's low pH. NIR signals of the NPs were provided by loaded IR-780 perchlorate dye and gold nanorods, Probes: luciferase, IR-780 dye (see supplemental figures) | cancer pancreatic-cancer | pancreatic-tumor-detection-and-treatment-with-novel-theranostic-particles |
Yuan, G., et. al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, 2021, 590(7846), 504-508. | Cancer, Lung cancer | Lung squamous cell carcinoma (LUSC) tumorigenesis | BLI | Mouse | Ami HTX | 1-Ning-Yi Shao, 2-Łukasz Jaremko, 3-Pawel K. Mazur, and 4-Or Gozani, 1-University of Macau, Macau SAR, China, 2-King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, 3-The University of Texas MD Anderson Cancer Center, Houston, TX, USA, and 4-Stanford University, Stanford, CA, USA | 2021 | | Lung squamous cell carcinoma (LUSC) tumorigenesis: Histone H3 lysine 36 (H3K36) methyltransferase NSD3 (located in the 8p11–12 amplicon) was identified as a key regulator of LUSC tumorigenesis. Specifically, a LUSC-associated variant NSD3 (T1232A) showed increased catalytic activity for dimethylation of H3K36 (H3K36me2) and was found to drive LUSC tumorigenesis, Probes: luciferase, akaLuc | cancer lung-cancer | lung-squamous-cell-carcinoma-lusc-tumorigenesis |
Yoon, H.Y., et. al., Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 2014, 4(1), 6878. | Cancer, Prostate Cancer | Glycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehicles | FLI | Mouse | Ami HTX | 1-Kwangmeyung Kim and 2-Martin G. Pomper, 1-Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea, 2-Johns Hopkins School of Medicine, Baltimore, MD, USA | 2014 | | Glycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehicles: Authors developed CNPs loaded with both doxorubicin (DOX) and Bcl-2 siRNA. These dual-therapeutic,loaded CNPs effectively reduced prostate tumor load in a mouse model, Probe: Cy5.5 | cancer prostate-cancer | glycol-chitosan-nanoparticles-cnps-as-specialized-cancer-therapeutic-vehicles |
Yong, C., et. al., Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 2020, 15(9). | Cancer, Prostate Cancer | Castration resistant invasive prostate cancer | BLI | Mouse | Ami HTX | Michael D. Henry, University of Iowa, Iowa City, IA, USA | 2020 | | Castration resistant, invasive prostate cancer: A Pten/Trp53 double knockout mouse model of castrate resistant, invasive prostate cancer was monitored with non-invasive bioluminescent imaging. This model was set up by employing a Probasin-Cre mediated deletion of Pten and Trp53, coupled with the activation of a ROSA-LSL luciferase reporter., Probe: luciferase | cancer prostate-cancer | castration-resistant-invasive-prostate-cancer |
Yin, W., et. al., Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences, Senior Honors Theses, 2016, Paper 126. | Cancer, Pancreatic Cancer | Directed-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinoma | FLI, BLI | Mouse | Ami HTX | Wenyuan Yin, University of Louisville, Louisville, KY, USA | 2016 | | Directed-liposome as a theranostic nanoparticle, and a therapeutic delivery mechanism for pancreatic adenocarcinoma: A syndecan-1-tagged liposome, loaded with fluorescent dye, achieved both specific pharmacokinetics to and non-invasive detection of orthotopic pancreatic cancer, as determined by multispectral optoacoustic tomography, Probes: luciferase, CF-750 | cancer pancreatic-cancer | directed-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma |
Yin, W., et. al., Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography, Journal of Nanobiotechnology, 2015, 13:90. | Cancer, Pancreatic Cancer | Directed-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinoma | FLI, BLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2015 | | Directed-liposome as a theranostic nanoparticle, and a therapeutic delivery mechanism for pancreatic adenocarcinoma: A syndecan-1-tagged liposome, loaded with fluorescent dye, achieved both specific pharmacokinetics to and non-invasive detection of orthotopic pancreatic cancer, as determined by multispectral optoacoustic tomography, Probes: CF-750, propidium iodide, luciferase | cancer pancreatic-cancer | directed-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma |
Yang, H., et. al., Endogenous IgG-based affinity-controlled release of TRAIL exerts superior antitumor effects, Theranostics, 2018, 8(9): 2459-2476. | Cancer, Colorectal Cancer | TRAIL in vivo pharmacokinetics optimized for superior antitumor efficacy | FLI | Mouse | Lago X | Xiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China | 2018 | | TRAIL in vivo pharmacokinetics optimized for superior antitumor efficacy: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was fused to endogenous IgG binding domain (IgGBD) moiety to enhance serum half-life, without any steric hindrance of TRAIL binding to its apoptosis-inducing site on tumors. In vivo trials showed that IgG-based affinity-controlled release of IgBD-TRAIL, did indeed lead to greater serum half-life and anti-tumor efficacy of TRAIL moiety. , Probe: CF750 | cancer colorectal-cancer | trail-in-vivo-pharmacokinetics-optimized-for-superior-antitumor-efficacy |
Yadav, S., et. al., MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 2017, Vol. 19, No. 4, pp. 321-332 | Cancer, Lung cancer | miRNA-mediated loss of Ubiquilin protein expression | FLI, BLI | Mouse | Ami HT | 1,2-Sanjay Yadav and Levi J. Beverly, 1-University of Louisville, Louisville, KY, USA, 2-CSIR-Indian Institute of Toxicology Research, Lucknow, India | 2017 | | miRNA-mediated loss of Ubiquilin protein expression: An increase in miRNA expression (specifically MIR155) increased lung cell invasion, migration, wound formation and clonogenicity in UBQLN-loss dependent manner. Background: Pollution carcinogen, diesel exhaust particles (DEP), found to upregulate Ubiquilin expression (and suppress MIR155 expression) and so initially protect lung cells; however, authors propose that "...DEP-induced repression of MIR155 leads to increased UBQLN levels, which in turn may be a selective pressure on lung cells to lose UBQLN1.", Probes: luciferase, GFP | cancer lung-cancer | mirna-mediated-loss-of-ubiquilin-protein-expression |
Wu, B., et. al., Oligo(ethylene glycol)-functionalized squaraine fluorophore as a near-infrared-fluorescent probe for the in vivo detection of diagnostic enzymes. Analytical Chemistry, 2018, 90:9359-9365. | Cancer, Liver Cancer | In vivo detection of tumor-associated diagnostic enzymes | FLI | Mouse | Ami HT | Fang Zeng and Shuizhu Wu, South China University of Technology, Guangzhou, China | 2018 | | In vivo detection of tumor-associated, diagnostic enzymes: Leucine aminopeptidase (LAP), expressed at high levels in hepatomas, can function as a diagnostic enzyme, where an activatable, NIR squaraine fluorophore is specifically cleaved (and so activated) by LAP. Aqueous solubility (functionality) of this squaraine fluorophore has been improved by a oligo (ethylene glycol) addition, Probe: Oligo (ethylene glycol) modified Squaraine | cancer liver-cancer | in-vivo-detection-of-tumor-associated-diagnostic-enzymes |
Wen, F., et. al., Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 2013, 73(14), pp.4256–4266. | Cancer, Pancreatic Cancer | Extracellular DNA promotes tumor-associated inflammation; cell invasion and aggressive metastasis | BLI | Mouse | Ami HT | 1-Fushi Wen and 2-Jiaqi Shi, 1-University of Arizona, Tucson, AZ, USA, 2-University of Michigan, Ann Arbor, MI, USA | 2013 | | Extracellular DNA (ExDNA) promotes tumor-associated inflammation, cell invasion and aggressive metastasis: ExDNA containing fibers from neutrophils (nicknamed neutrophil extracellular traps or NETs found on the surface of pancreatic cancer cells, believed to be involved in inflammatory positive feedback loop (promoting expression of the inflammatory chemokine CXCL8 which led to more ExDNA), tumor growth and metastases suppressed by DNase 1 treatment, Probe: luciferase | cancer pancreatic-cancer | extracellular-dna-promotes-tumor-associated-inflammation-cell-invasion-and-aggressive-metastasis |
Watson, J.R., et.al., Intraoperative imaging using intravascular contrast agent. Society of Photo-Optical Instrumentation Engineers, Conference Proceedings, 2016, Vol.9696. | Cancer, Glioblastoma | Intraoperative tumor detection | BLI, FLI | Rat | Lago X | Marek Romanowski, University of Arizona, Tucson, AZ, USA | 2016 | | Intraoperative tumor detection: Indocyanine green (ICG) tumor uptake by enhanced permeability and retention effect (EPR). Tumor surgical resection guided by ICG NIR fluorescent signal as viewed by augmented microscopy. ICG NIRF confirmed by bioluminescent signal of Luc-C6 glioblastoma used in rat model, Probes: luciferase, ICG | cancer glioblastoma | intraoperative-tumor-detection |
Varzavand, A., et. al., α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer Research, 2016, 76(22), 6577–6587. | Cancer, Prostate Cancer | Prostate cancer metastasis regulation | BLI, FLI | Mouse | Ami X | Michael D. Henry and Christopher S. Stipp, University of Iowa, Iowa City, IA, USA | 2016 | | Prostate cancer metastasis regulation: Have identified an a3 integrin-Abl kinase-Hippo suppressor pathway in prostate cancer in which a3b1 integrin signals through Abl kinases to restrain Rho GTPase activity, sustain Hippo suppressor functions,and curtail metastatic cell phenotypes., Probes: luciferase, GFP | cancer prostate-cancer | prostate-cancer-metastasis-regulation |
Tao, Z., et. al., Targeted delivery to tumor-associated pericytes via an affibody with high affinity for PDGFRβ enhances the in vivo antitumor effects of human TRAIL. Theranostics, 2017, 7(8): 2261-2276. | Cancer, Colon Cancer | Tumor-targeted hTRAIL therapy | FLI | Mouse | Lago X | Xiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China | 2017 | | Tumor-targeted hTRAIL therapy: Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) was fused to an affibody with high affinity for platelet-derived growth factor receptor β (PDGFRβ), which is expressed by pericytes that are enriched in tumor tissues. This affibody-mediated binding of hTRAIL to tumor cells did not interfere with hTRAIL's death receptor binding and activation, and indeed, tumor hTRAIL uptake and antitumor effect was increased in colorectal xenografts in mice, Probe: CF750 | cancer colon-cancer | tumor-targeted-htrail-therapy |
Tang, A.C., et. al. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. Cell Death and Disease, 2018, 9:162. | Cancer, haematological malignancies | Combination therapy of proteasome inhibitors and Toll-like receptor agonists | BLI | Mouse | Ami HTX | Stuart E. Turvey, University of British Columbia, Vancouver, BC, Canada | 2018 | | Combination therapy of proteasome inhibitors and TLR agonists: enhances tumour cell death and IL-1β production, Probe: GFP-luciferase | cancer haematological-malignancies | combination-therapy-of-proteasome-inhibitors-and-toll-like-receptor-agonists |
Sukumar, U.K., et. al., SP94-targeted triblock copolymer nanoparticle delivers thymidine kinase-p53-nitroreductase triple therapeutic gene and restores anticancer function against hepatocellular carcinoma in vivo. ACS Applied Material Interfaces, March 2020, 12(10): 11307-11319. | Cancer, Hepatocellular Carcinoma | Gene-directed enzyme–prodrug therapy (GDEPT) | BLI, FLI | Mouse | Lago | Ramasamy Paulmurugan, Stanford University School of Medicine, Palo Alto, CA, USA | 2020 | | Gene-directed enzyme–prodrug therapy (GDEPT): Used triblock copolymer NPs: Polyethylenimine (PEI) conjugated with poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) for non-toxic delivery of negative nucleic acids, and for delivery of a rationally engineered thymidine kinase (TK)–p53–nitroreductase (NTR) triple therapeutic to restore p53 function and potentiate cancer cell response to delivered prodrugs (ganciclovir (GCV) and CB1954) with expression of suicide genes (TK,NTR). Hepatocellular carcinoma (HCC) tumor-targeting of NPs achieved with addition of SP94 peptide, Probes: luciferase, CytoCy5 | cancer hepatocellular-carcinoma | gene-directed-enzyme-prodrug-therapy-gdept |
Sukumar, U.K., et. al., Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to Temozolomide. Biomaterials, October 2019, 218. | Cancer, Glioblastoma | Theranostic; intranasal and systemic combinatorial therapy of GBM | BLI | Mouse | Lago X | 1-Tarik F. Massoud and 2-Ramasamy Paulmurugan, 1-Stanford University School of Medicine, Stanford, CA, USA, 2-Stanford University School of Medicine, Palo Alto, CA, USA | 2019 | | Theranostic, intranasal and systemic combinatorial therapy for GBM: use intranasal delivery of theranostic, polyfunctional gold-iron oxide nanoparticles (polyGIONs) surface-loaded with therapeutic Cy5-miRNAs (miR-100 and antimiR-21), along with systemically delivered chemotherapy drug temozolomide (TMZ), to treat orthotopic mouse model of FLUC-EGFP labeled U87-MG GBMs, Probes: luciferase, Cy5 | cancer glioblastoma | theranostic-intranasal-and-systemic-combinatorial-therapy-of-gbm |
Suhardi, V.J., et. al., A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. Nat Biomed Eng. 2017, 1. | Revision of Infected Prosthetic Joints | Antibiotic drug delivery and mechanical strength of prosthetic joint implant material | BLI | Rabbit | Ami HTX | 1,2-E Oral, 1-Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, MA, USA, and 2-Harvard Medical School, Cambridge, MA, USA | 2017 | | Optimize joint implant antibiotic drug delivery and mechanical strength: Modified eccentricity of
drug clusters and percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) to maximize drug elution rate while retaining UHMWPE mechanical strength. Lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects, outperforming the current clinical gold standard model of antibiotic-eluting bone cement joint construct, Probe: luciferase | revision-of-infected-prosthetic-joints | antibiotic-drug-delivery-and-mechanical-strength-of-prosthetic-joint-implant-material |
Su, Y., et. al., Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals, Nature Methods, 2020, 17, 852–860. | Bioluminescent Imaging | Dual Bioluminescence Imaging | BLI | Mouse | Ami HT | 1-Thomas A. Kirkland, and 2-Michael Z. Lin, 1-Promega Biosciences LLC, San Luis Obispo, CA, USA, 2-Stanford University, Stanford, CA, USA | 2020 | | New Nanoluc substrate enhances dual in vivo bioluminescence imaging: Previously, Antares, a fusion of NanoLuc to the orange fluorescent protein CyOFP (an example of BRET) used with AkaLuc and its substrate AkaLumine to provide a dual biolum, as the two luciferases have orthogonal substrate specificity. NanoLuc bioluminescence brightness has been improved: first, with hydro-furimazine, and then even more so with fluorofurimazine. Used Antares with fluorofurimazine to track tumor size, AkaLuc/Akalumine to visualize CAR-T cells within the same mice, Probes: Antares, AkaLuc | bioluminescent-imaging | dual-bioluminescence-imaging |
Stokes, J., et. al., Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 2016, 174(1), 102–116. | Cancer, Lymphoma | GVHD prevention and GVL preservation | BLI | Mouse | Lago | Emmanuel Katsanis, University of Arizona, Tucson, AZ, USA | 2016 | | GVHD prevention and GVL preservation: in cases of haploidentical bone marrow transplantation (h-BMT), achieved by post-transplant bendamustine treatment, Probe: luciferase | cancer lymphoma | gvhd-prevention-and-gvl-preservation |
Song, J.H. & Kraft, A.S., Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 2016, 76(s14), 4414–4414. | Cancer, Lymphomas | Pim Kinase substrates and associated regulatory pathways | BLI | Mouse | Lago X | Jin H. Song, and Andrew S. Kraft, University of Arizona, Tucson, AZ, USA | 2016 | | Haematopoietic malignancies: Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Therefore, aim to identify Pim substrates to determine pathways regulated by enzymes, and to have substrates serve as possible biomarkers of Pim kinase activity, Probe: luciferase | cancer lymphomas | pim-kinase-substrates-and-associated-regulatory-pathways |
Shin, J.M., et. al., A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy. Biomaterials Research, 2018, 22:21. | Cancer, Cervical Cancer | Immunotherapy by polymeric antigen carrier | FLI | Mouse | Lago X | Jae Hyung Park, Sungkyunkwan University, Suwon, Republic of Korea | 2018 | | Immunotherapy by polymeric antigen carrier: Carboxymethyl dextran (CMD) used as the polymeric backbone and ovalbumin (OVA)
as a model foreign antigen, CMD-OVA conjugate successfully taken up by TC-1 cervical cancer in vivo, , Probe: Cy5.5 | cancer cervical-cancer | immunotherapy-by-polymeric-antigen-carrier |
Shi, Q., et. al., PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 2017, 24(1), pp.1818–1830. | Cancer, Colorectal Cancer | Photodynamic therapy | FLI | Mouse | Lago X | Xiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China | 2017 | | Photodynamic therapy (PDT) specificity enhanced by targeting vascular pericyte membrane protein, PDGFRb: Photosensitizer, IR700, conjugated to affibody directed against PDGFRb, showed binding specificity to tumor vascular PDGFRb in vivo. Ensuing PDT intensitied tumor specific hypoxia, and reduced in tumor mass vs. negative controls. Additionally, above PDT led to increased tumor uptake of TNF-related apoptosis-inducing ligand (TRAIL) injected post-illumination. This dual therapy showed greater tumor suppression than either mono-therapy, Probe: IR700 | cancer colorectal-cancer | photodynamic-therapy |
Shankar, G.M., et. al., Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(36), E8388–E8394. | Cancer, Glioblastoma | Genotype-targeted therapy | BLI | Mouse | Ami HTX | 1,2-Giovanni Traverso, and 3-Daniel P. Cahill, 1-Massachusetts Institute of Technology, Cambridge, MA, USA, 2-Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, and 3-Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA | 2018 | | Genotype-targeted therapy of low grade gliomas: Given that most low grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) or IDH2 mutations, they are sensitive to metabolism-altering agents. Developed and tested an intraoperative treatment that coupled both a rapid multiplexed genotyping for IDH mutant gliomas (by qPCR following resection) with, if positive, a sustained release of IDH-directed nicotinamide phosphoribosyltransferase (NAMPT) inhibitor from loaded microparticles (MPs) as a locally toxic therapy, Probe: luciferase | cancer glioblastoma | genotype-targeted-therapy |
Schüler, E., et. al., Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 2017, 97(1), 195–203. | Cancer, Radiation Oncology | protocol development, Ultra-high dose rate irradiation (>50 Gy/s “FLASH”) | XRAY | Mouse | Ami HTX | Peter G. Maxim, Stanford University School of Medicine, Stanford, CA, USA | 2017 | | New radiation therapy technique with potentially minimal normal tissue toxicity: Protocol development of ultra-high dose rate irradiation (>50 Gy/s, “FLASH”) electron small animal irradiation with a clinically available linear accelerator (LINAC), Probe: none, X-ray imaging | cancer radiation-oncology | protocol-development ultra-high-dose-rate-irradiation-50-gy-s-flash |
Samykutty, A., et. al., Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging. Biotech Histochemistry, 2018, 93(8), 608-614. | Breast Cancer, Cancer | Detection and monitoring of breast cancer by a osteopontin-NIR fluorophore conjugate | FLI | Mouse | Ami HT | Lacey R. McNally, Wake Forest School of Medicine, Winston-Salem, NC, USA | 2018 | | Breast cancer detection and monitoring: Use of a osteopontin-NIR fluorophore conjugate. Multispectral optoacoustic tomography (MSOT), confirmed by NIRF imaging, confirmed probe's in vivo specificity for breast tumor in mouse model , Probe: Hilyte 750 succinyl ester dye | breast-cancer cancer | detection-and-monitoring-of-breast-cancer-by-a-osteopontin-nir-fluorophore-conjugate |
Rice, M.A., et. al., Loss of Notch1 activity inhibits prostate cancer growth and metastasis and sensitizes prostate cancer cells to antiandrogen therapies. Molecular Cancer Therapeutics, 2019, 18(7): 1230–1242. | Cancer, Prostate Cancer | NOTCH1 and Notch1 activity as therapeutic targets of aggressive prostate cancer | BLI | Mouse | Lago | Tanya Stoyanova, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, USA | 2019 | | Prostate cancer: Notch1 as a therapeutic target: Loss of NOTCH1 in aggressive prostate cancer led to decreases in proliferation, invasion, tumorsphere formation, and metastatic potential. Inhibitors of Notch1 activity by Gamma secretase inhibitors RO4929097or DAPT further reduced prostate tumor cell proliferation. Loss of NOTCH1 combined with inhibitor therapies could delay development of castration-resistant prostate cancer (CRPC) and metastic events., Probe: luciferase | cancer prostate-cancer | notch1-and-notch1-activity-as-therapeutic-targets-of-aggressive-prostate-cancer |
Qiu, X.Y., et. al., PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. BBA – Molecular Basis of Disease, 2018, 1864: 1754-1769 | Cancer, Glioblastoma | Programmed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme malignancy | FLI | Mouse | Lago X | Xiao Qian Chen, Huazhong University of Science and Technology, Wuhan, China | 2018 | | Programmed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme maligency: PD-L1 binding to intracellular Ras leads to enhanced GBM malignancy via activating Ras-Erk-EMT (epithelial mesenchymal transition) axis signaling. 1. And PD-L1 knockdown (by lentiviral infection (LV-sh-PD-L1, with EGFP tag)) abolished GBM development, Probe: eGFP | cancer glioblastoma | programmed-cell-death-ligand-1-pd-l1-expression-level-correlated-with-glioblastoma-multiforme-malignancy |
Phuong, P.T.T., et. al., Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy. Colloids and Surfaces B: Biointerfaces, 2018, 171: 123-133. | Breast Cancer, Cancer | Breast tumor ablation by photodynamic therapy | FLI | Mouse | Lago X | Beom Soo Shina, and Yu Seok Youn, Sungkyunkwan University, Suwon, Republic of Korea | 2018 | | Breast tumor ablation by photodynamic therapy: Chlorin e6 (Ce6) used as a 2nd generation photosynthesizer therapeutic and fluorophore probe, and Ce6 water solubility was improved with "nab" (nanoparticle albumin-bound) technology, including beta-carotene as a cross-linker in the final, loaded albumin NPs, Ce6-BSA-BC-NPs, which showed efficacy vs 4T1 breast tumor xenografts following 660 nm laser irradiation in a mouse model, Probe Ce6 | breast-cancer cancer | breast-tumor-ablation-by-photodynamic-therapy |
Park, S.B., et. al., Bioluminescence imaging of matrix metalloproteinases-2 and -9 activities in ethanol-injured cornea of mice. In vivo, 2021, 35: 1521-1528. | Eye Corneal Injury and Healing | Non-invasive monitoring eye corneal injury and healing | FLI | Mouse | Ami HTX | Kyung-Jong Won, Konkuk University School of Medicine, Seoul, Republic of Korea | 2021 | | Non-invasive monitoring eye corneal injury and healing: following 20% ethanol treatment, the extent of eye (corneal epithelial) apoptosis and inflammation was assessed by matrix metalloproteinases (MMP)-2 and MMP-9 activation and activity, as indicated by fluorescence signal intensity of activatable probe NpFlamma® MMP-2/9; eye drops (hyaluronic acid and serum) efficacy was noted by a reduction in NpFlamma® MMP-2/9 signal, Probe: NpFlamma® MMP-2/9 | eye-corneal-injury-and-healing | non-invasive-monitoring-eye-corneal-injury-and-healing |
Park, S., et. al., Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation. Journal of Controlled Release, 2019, 304: 7-18. | Cancer, Colon Cancer | Tumor Detection and Ablation by hybrid gold nanoclusters (AuNCs) | FLI | Mouse | Lago X | Yu Seok Youn, Sungkyunkwan University, Suwon, Republic of Korea | 2019 | | Tumor Detection and Ablation by hybrid gold nanoclusters (AuNC): Smaller AuNC (<1-2 nm) allow Cy5.5 fluorescence, Larger AuNC (several nm in size) are good hyperthermic agents. Together, as a hybrid population of AuNCs, with albumin (AuNCs/BSA-NPs), tumor specific uptake, detection, and ablation (by laser therapy) is achieved in a colon cancer model, Probe: Cy 5.5 | cancer colon-cancer | tumor-detection-and-ablation-by-hybrid-gold-nanoclusters-auncs |
Park, J., et. al., Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceuticals, 2019 May, 16(5): 1864-1873. | Breast Cancer, Cancer | Improving NP delivery to tumor micro environment (TME) | FLI | Mouse | Ami HT | Yoon Yeo, Purdue University, West Lafayette, IN , USA | 2019 | | Primary tumor pretreatment with iron-oxide Nanoparticles: Facilitate penetration into the tumor microenvironment (TME), without elevating occurrences of metastases, by the timely application of paclitaxel (PTX)-loaded iron oxide decorated poly(lactic-co-glycolic acid) nanoparticle composite (PTX@PINC) along with an external magnet, prior to secondary NP treatment, Probe: DiR | breast-cancer cancer | improving-np-delivery-to-tumor-micro-environment-tme |
Pandurangi, R.S., et. al., A priori activation of apoptosis pathways of tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment, PLoS ONE, 2021, 16(2). | Cancer, various | A priori activation of apoptosis pathways of tumor technology (AAAPT) | BLI | Mouse | Lago | Raghu S. Pandurangi, Sci-Engi-Medco Solutions Inc., St Charles, Missouri, USA | 2021 | | A priori activation of apoptosis pathways of tumor technology (AAAPT): to activate specific cell death pathways and inhibit survival pathways, simultaneously, and to act selectively in cancer cells sparing normal cells. Tested novel therapeutic AMP-001-003 vs. MDA-MB-231 (triple negative breast cancer), PC3 (prostate cancer) and A543 (lung cancer) cells, Probe: luciferase | cancer various | a-priori-activation-of-apoptosis-pathways-of-tumor-technology-aaapt |
Padi, S.K.R., et. al., Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 2017, 77(s13): 5820–5820. | Cancer, T-cell Acute Lymphoblastic Leukemias | pan-PIM Protein Kinase Inhibitor and Ponatinib vs.T-cell acute lymphoblastic leukemia subgroup | BLI | Mouse | Lago X | Andrew S. Kraft, University of Arizona, Tucson, AZ, USA | 2017 | | T-cell acute lymphoblastic leukemia: Treatment by pan-PIM protein kinase inhibitors vs. T-cell
acute lymphoblastic leukemia (T-ALL) subset, early T-cell precursors (ETPs) with elevated PIM1 expression (and no NOTCH mutation), and combinatorial treatment with Ponatinib, a broadly active tyrosine kinase inhibitor, led to significantly better efficacy, Probe: luciferase | cancer t-cell-acute-lymphoblastic-leukemias | pan-pim-protein-kinase-inhibitor-and-ponatinib-vs-t-cell-acute-lymphoblastic-leukemia-subgroup |
O’Leary, M.P., et. al., Novel oncolytic chemeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose. Journal of Translational Medicine, 2018, 16:110. | Cancer, Pancreatic Cancer | Oncolytic viral therapy vs. Pancreatic Cancer | BLI | Mouse | Lago X | Nanhai G. Chen, City of Hope National Medical Center, Duarte, CA, USA | 2018 | | Oncolytic Chimeric Orthopoxvirus: Recombinant virus encoding firefly luciferase, CF33-Fluc, specific uptake, replication in, and lysis of pancreatic tumors in PANC-1 and MIA PaCa-2 xenograft models., Probe: luciferase | cancer pancreatic-cancer | oncolytic-viral-therapy-vs-pancreatic-cancer |
O’Leary, M.P., et. al., A novel oncolytic chimeric orthopoxvirus encoding luciferase enable real-time view of colorectal cancer cell infection. Molecular Therapy Oncolytics, June 2018, 9: 13-21. | Cancer, Colorectal Cancer | Oncolytic viral therapy vs. Colorectal Cancer | BLI | Mouse | Lago X | Nanhai G. Chen, City of Hope National Medical Center, Duarte, CA, USA | 2018 | | Oncolytic Chimeric Orthopoxvirus: Recombinant virus encoding firefly luciferase, CF33-Fluc, specific uptake, replication in, and lysis of HCT-116 colorectal tumor xenograft in mouse model., Probe: luciferase | cancer colorectal-cancer | oncolytic-viral-therapy-vs-colorectal-cancer |
O’Leary, B.R., et. al., Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 2020, 10: 17649 | Cancer, Pancreatic Cancer | Pharmacological ascorbate treatment of pancreatic ductal adenocarcinoma (PDAC) | BLI | Mouse | Ami HTX | Joseph J. Cullen, and Michael D. Henry, University of Iowa, Iowa City, IA, USA | 2020 | | Pharmacological ascorbate (high-dose, intravenous vitamin C): cytotoxic specifically to pancreatic ductal adenocarcinoma (PDAC), it prevents PDAC metastases by inducing oxidative stress specifically in PDAC cells, not in normal somatic cells; mechanism: hydrogen peroxide production by auto oxidation of pharmacological ascorbate; observed a reduction in circulating tumor cell (CTC) nucleases following ascorbate treatment , Probe: luciferase | cancer pancreatic-cancer | pharmacological-ascorbate-treatment-of-pancreatic-ductal-adenocarcinoma-pdac |
O’Leary, B.R., et. al., Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma, AARC, Clinical Cancer Research, January 29, 2015. | Cancer, Pancreatic Cancer | Extracellular Superoxide Dismutase (SOD) as therapeutic target for treatment of pancreatic adenocarcinoma (PDA) | BLI | Mouse | Ami HT | James J. Mezhir, University of Iowa, Iowa City, IA, USA | 2015 | | Pancreatic ductal adenocarcinoma (PDA): cells lines overexpressing extracellular superoxide dismutase (EcSOD) demonstrated slower growth rates, and loss of EcSOD leading to increase in superoxide and nitric oxide interaction, lead to invasive phenotype supporting aggressive and refractory nature of PDA; treatment with SOD mimetics could be clinically effective vs. PDA, Probe: luciferase | cancer pancreatic-cancer | extracellular-superoxide-dismutase-sod-as-therapeutic-target-for-treatment-of-pancreatic-adenocarcinoma-pda |
Nishihara, R., et. al., Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo. Theranostics, 2019, 9(9): 2646-2661. | Breast Cancer, Cancer | NIR-BRET probes for in vivo monitoring of tumor metastases, protein-protein interactions | BLI,FLI,BRET | Mouse | Lago | Koji Suzuki, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan | 2019 | | Bright and stable NIR-BRET in vivo probe: Emission peak of coelenterazine (CTZ) derivatives tuned to Soret band (blue light absorption peak) of iRFP, this NIR-BRET conjugate, encoded in mammalian plasmid, was expressed in human breast cancer (MDA-MB231) cells, and detection of cells was evaluated in mouse in model, NIR-BRET probe to be used for detection of metastases and protein-protein interactions, Probes: coelenterazine derivative (RLuc8.6-535SG) combined with iRFP | breast-cancer cancer | nir-bret-probes-for-in-vivo-monitoring-of-tumor-metastases protein-protein-interactions |
Moose, D.L., et. al., Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 2020, 30: 1-11. | Cancer, Prostate Cancer | Mechanism of Resilience of circulating tumor cells (CTCs) | BLI | Mouse | Ami HTX | Michael D. Henry,University of Iowa, Iowa City, IA, USA | 2020 | | Resilience of circulating tumor cells (CTCs): exhibit a mechano-adaptive response to fluid shear stress, involves activation of RhoA-actomyosin signaling axis, this signalling is shown to support intravascular survival of CTCs, Probe: luciferase | cancer prostate-cancer | mechanism-of-resilience-of-circulating-tumor-cells-ctcs |
Meng, F., et. al., Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited, ACS Nano, 2018, July 24, 12(7): 6458-6468. | Fluorescence Imaging | Fluorescence signal quenching in fluorophore-loaded nanoparticles | FLI | Mouse | Ami HT | Yoon Yeo, Purdue University, West Lafayette, IN , USA | 2018 | | Fluorescence signal quenching in nanoparticles (NPs) loaded with fluorophore: DiR-loaded poly(lactic-co-glycolic acid) (PLGA) NPs show inverse correlation between DiR concentration/NP and signal strength, Probe: DiR | fluorescence-imaging | fluorescence-signal-quenching-in-fluorophore-loaded-nanoparticles |
Marecic, O., et al., Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 2015, 112(32): 9920–9925. | Bone Growth, Repair | cartilage, Distinct gene expression and phenotype of fracture-induced bone, stromal progenitor (f-BCSP) cells | XRAY | Mouse | Ami HTX | Irving L. Weissman, Charles K. F. Chan, and Michael T. Longaker, Stanford University School of Medicine, Stanford, CA, USA | 2015 | | Fracture-induced bone, cartilage, stromal progenitor (f-BCSP) cells: Gene expression pattern and phenotype are similar to that in perinatal skeletogenesis, but distinct from BCSP cells from uninjured bone, f-BCSP cells may be functionally stratified, containing distinct subsets responsible for growth, regeneration, and repair, Probe: none, X-ray imaging | bone-growth repair | cartilage distinct-gene-expression-and-phenotype-of-fracture-induced-bone stromal-progenitor-f-bcsp-cells |
Marchal, M.A., et. al., Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis. bioRxiv, 2020. | Cancer, Prostate Cancer | Metastatic castration-resistant prostate cancer (mCRPC) | BLI | Mouse | Ami HT | Michael D. Henry, Christopher S. Stip, University of Iowa, Iowa City, IA, USA | 2020 | | Prostate Cancer: metastatic castration resistant prostatic cancer, Alb deficient cell line showed elevated growth rate associated with AKT pathway activation, Abl kinase inhibitor mimicked Alb deficient cells, inhibitor of AKT pathway reduced tumor growth rate, Probe: luciferase | cancer prostate-cancer | metastatic-castration-resistant-prostate-cancer-mcrpc |
Lucero-Acuña A., et. al., Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014,1: 5653–5665. | Cancer, Pancreatic Cancer | Overcoming Severe Desmoplasia | BLI | Mouse | Ami HT | Emmanuelle J. Meuillet, University of Arizona, Tucson, AZ, USA | 2014 | | Pancreatic Cancer Desmoplasia: Severe in pancreatic cancer cell strains with K-Ras mutation, improve therapeutic delivery (e.g. PH-427) by poly (lactic-co-glycolic acid) nanoparticles (PNP), Probe: luciferase | cancer pancreatic-cancer | overcoming-severe-desmoplasia |
Liu, M., et. al., Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 2015, 195(10): 5055–5065. | Cancer, Lung cancer | M2 to M1 activated macrophage conversion | Dual FLI | Mouse | Ami HT | Jun Yan, University of Louisville, Louisville, KY, USA | 2015 | | Lung Cancer: Immunosuppressive M2 tumor associated macrophages (TAMs) and bone marrow derived macrophages (BMMs) converted to M1 tumoridical MOs by B-glucan treatment, Probes: XenoLight DiR and VivoTrack 680 | cancer lung-cancer | m2-to-m1-activated-macrophage-conversion |
Ling, Q., et. al., The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 2017, 8(9): 15159–15167. | Cancer, Pancreatic | Associated miRNA expression on PDAC recurrence, Prognostic relevance of primary PDAC location | BLI | Mouse | Ami HT | 1-Holger Kalthoff, and 2,3-Shusen Zheng, 1-Comprehensive Cancer Center North, CAU, Kiel, Germany, 2-College of Medicine, Zhejiang University, Hangzhou, China, and 3-Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, China | 2017 | | Pancreatic ductal adenocarcinoma (PDAC): Recurrence rates of PDAC following early stage resection appear, by clinical data, to be a function primary PDAC location, with body/tail cancer being a less malignant phenotype than head cancer; deregulation (elevated) expression of miRNA (miR-501-3p) promotes PDAC recurrence and metastases, Probe: luciferase | cancer pancreatic | associated-mirna-expression-on-pdac-recurrence prognostic-relevance-of-primary-pdac-location |
Li, Y., et. al., Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of Immunology, 2015, 194(3): 1011-1020. | Cancer, Lymphoma | GVHD prevention and GVT preservation by helminth injection associated induction of Tregs | BLI | Mouse | Ami HT | M. Nedim Ince, University of Iowa, Iowa City, IA, USA | 2015 | | Graft vs. Host Disease (GVHD) prevention and Graft vs. Tumor (GVT) immunity preservation: achieved with helminth, H. polygyrus oral injection, leading to activation of regulatory T cells (Tregs) that modulate effector T cell associated intestinal inflammation, and any intestinal bowel disease (IBD), B cell lymphoma burden tracked by Luciferase-expressing A20 (A20-luc) lymphoma cells, Probe: luciferase | cancer lymphoma | gvhd-prevention-and-gvt-preservation-by-helminth-injection-associated-induction-of-tregs |
Li, S., et. al., Near infrared fluorescent imaging of brain tumor with !R780 dye incorporated phospholipid nanoparticles, Journal of Translational Medicine, 2017, 15:18 | Cancer, Glioblastoma | Image guided oncological surgery, Tumor Detection | FLI | Mouse | Ami HT | 1-Shihong Li, and 1,2-Qian Xie, 1-Van Andel Research Institute, Grand Rapids, MI, USA, and 2-East Tennessee State University, Johnson City, USA | 2017 | | Glioblastoma tracking: Phospholipid micelle and liposome NPs used to deliver NIR fluorescent probe IR780 through blood brain barrier, for accumulation in orthotopic glioblastoma cells by EPR effect, Probe: IR780 | cancer glioblastoma | image-guided-oncological-surgery tumor-detection |
Lee, S.Y., et. al., Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma. Biomaterials Science, 2019. | Cancer, Lung cancer | Nanoparticle drug delivery optimization | FLI | Mouse | Ami HT | Hyun-Jeong Ko, and Hyun-Jong Cho, Kangwon National University, Chuncheon, Republic of Korea | 2019 | | Lung adenocarcinoma treatment: Biocompatible, biodegradable, hyaluronic acid (HA), a disaccharide, along with 4-phenylbutyric acid (PBA), with hydrophobic and hydrophilic moieties, used to build PBAHA NPs for loading curcumin (CUR), HA binding to CD44 and CD168 used as active tumor targeting, combined antitumor activities of PBA and CUR tested, NPs tracked with Cy 5.5, Probe: Cy5.5 | cancer lung-cancer | nanoparticle-drug-delivery-optimization |
Lee, S.Y., et. al., An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy. Drug Delivery, 2018, 25(1): 738-749. | Breast Cancer, Cancer | Nanoparticle enzyme-based therapeutic | FLI | Mouse | Lago | Hyun-Jong Cho, Kangwon National University, Chuncheon, Republic of Korea | 2018 | | Breast Cancer treatment: enzyme-based nanocarrier therapeutic, nano assembly (NA) of D-a-tocopherol succinate conjugated to lysozyme enzyme, loaded with curcumin, tumor specificity is passive by enhanced permeability and retention (EPR) effect, reduced tumor growth, induced apoptosis via mitochondrial destabilization, Probe: Cy5.5 | breast-cancer cancer | nanoparticle-enzyme-based-therapeutic |
Lee, S.Y., et. al., Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the bloodstream and improved lung targeting efficiency. Journal of Colloid and Interface Science, 2016, 480: 102–108. | Cancer, Lung cancer | Nanoparticle drug delivery optimization | FLI | Mouse | Lago X | 1-In-Soo Yoon, and 2-Hyun-Jong Cho, 1-Mokpo National University, Jeonnam, Republic of Korea, and 2-Kangwon National University, Chuncheon, Republic of Korea | 2016 | | Lung Cancer: Optimized drug delivery: use of vascular, transient aggregation of chitosan-modified poly(D,L-lactic-co-glycolic) acid nanoparticles,CS-coated PLGA NPs, Probe: Cy5.5 | cancer lung-cancer | nanoparticle-drug-delivery-optimization |
Lee, J.J., et. al., Predictive modeling of in vivo response to gemcitabine in pancreatic cancer. PLoS Computational Biology, 2013, 9(9). | Cancer, Pancreatic Cancer | Predictive limits of in vitro drug efficacy studies | BLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2013 | | Pancreatic Cancer: predictive modeling of in vivo response to gemcitabine: inefficient vascularization and abundant stroma of tumor microenvironment lead to heterogeneous cell proliferation and death, and ensuing poor penetration and efficacy of gemcitabine treatment, Probe: luciferase | cancer pancreatic-cancer | predictive-limits-of-in-vitro-drug-efficacy-studies |
Lartey, F.M., et. al., Dynamic CT imaging of volumetric changes in pulmonary nodules correlates with physical measurements of stiffness. Radiotherapy Oncology, 2017 February, 122(2): 313-318. | Cancer, Lung cancer | Non-invasive scanning | XRAY | Rat | Ami HTX | Billy W. Loo, and Peter G. Maxim, Stanford University School of Medicine, Stanford, CA, USA | 2017 | | Lung cancer: non-invasive screening, X-ray guided tumor cell injections, pulmonary nodule stiffness or deformability, correlation with pulmonary nodule (PN) volume ratio, technologies used: PN stiffness: Young’s modulus using atomic force microscopy, PN volume ratio: respiratory-gated MicroCT, Probe: None, X-ray imaging | cancer lung-cancer | non-invasive-scanning |
Lahiji, S.F., et. al., Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth, Biomaterials, 2018. | Androgenetic Alopecia | Hair regrowth model | FLI | Mouse | Lago X | Hyungil Jung, Yonsei University, Seoul, Republic of Korea | 2018 | | Hair regrowth: androgenetic alopecia, valproic acid (VPA)-encapsulating dissolving microneedle (DMN-VPA), micro wounding, subdermal, Probe: FITC | androgenetic-alopecia | hair-regrowth-model |
Kumar, G.D., et. al., Modified coring tool designs reduce iceberg lettuce cross-contamination. Journal of Food Protection, 2019, 82(3): 454–462. | Plant Pathogens | Crop harvesting | BLI | Coring machine, Iceberg Lettuce | Ami HT | Sadhana Ravishankar, University of Arizona, Tucson, AZ, USA | 2019 | | Crop harvesting: Coring tool, minimizing bacterial cross-contamination, food safety, lettuce, Salmonella Newport serotype, Probe: luciferase | plant-pathogens | crop-harvesting |
Kimbrough, C.W., et. al., Targeting acidity in pancreatic adenocarcinoma: Multispectral optoacoustic tomography detects pH-low insertion peptide probes in vivo. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2015, 21(20): 4576–4585. | Cancer, Pancreatic Cancer | pH-low insertion peptides as TME-specific probe | BLI, FLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2015 | | pH-low insertion peptides (pHLIP): pH-sensitive membrane intercalation, target acidic tumor microenvironment (TME), pancreatic ductal adenocarcinoma, human pancreatic cancer cell line S2VP10, multispectral optoacoustic tomography (MSOT), Probes: HiLyte Fluor 750 C2 maleimide (AnaSpec) conjugated to pH insensitive pHLIP K7 or to ph sensitive pHLIP V7 | cancer pancreatic-cancer | ph-low-insertion-peptides-as-tme-specific-probe |
Kimbrough, C.W., et. al., Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 2015, 193(1): 246–254. | Cancer, Pancreatic Cancer | FLI and MSOT Detection Assay | BLI, FLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2015 | | Localizing orthotopic pancreatic adenocarcinoma: syndecan-1, human pancreatic cancer cell line S2VP10, multispectral optoacoustic tomography (MSOT), ICG as negative control dye, Probes: Syndecan-1, ICG, luciferase | cancer pancreatic-cancer | fli-and-msot-detection-assay |
Ke, B., et. al., In vivo bioluminescence imaging of cobalt accumulation in a mouse model. Analytical Chemistry, 2018, 90: 4946-4950. | Cobalt, Trace Element Nutrient Tracking | BLI Detection Assay | BLI | Mouse | Lago X | Lupei Du and Minyong Li, Shandong University, Jinan, Shandong, China | 2018 | | Trace element nutrient tracking: Cobalt, Cobalt Bioluminescent Probe 1 (CBP-1), luciferin-cage conjugate , Probe: luciferase | cobalt trace-element-nutrient-tracking | bli-detection-assay |
Kang, Y.Y., et. al., Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain, Phytomedicine, 2019, 62. | Central Nervous System, Inflammation | Combinatorial drug synergistic efficacy | FLI | Mouse | Lago X | Hyejung Mok, Konkuk University, Seoul, Republic of Korea | 2019 | | Byakangelicin enhances the pharmacokinetics (blood brain barrier (BBB) penetration) of various drugs: umbelliferone (Umb), curcumin (Cur), and doxorubicin (Dox), Probe: Green Fluorophore | central-nervous-system inflammation | combinatorial-drug-synergistic-efficacy |
Kaemmer, C.A., et. al., Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis. Nature Portfolio: Scientific Reports, 2021, 11. | Cancer, Pancreatic Cancer | Pancreatic neuroendocrine neoplasms (pNENs), preclinical BLI model development | BLI | Mouse | Ami HT | Dawn E. Quelle, University of Iowa, Iowa City, IA, USA | 2021 | | Pancreatic neuroendocrine neoplasms (pNENs): preclinical BLI model development, biodistribution, liver metastases, lung metastases, Probe: luciferase | cancer pancreatic-cancer | pancreatic-neuroendocrine-neoplasms-pnens preclinical-bli-model-development |
Johnson, J., et. al., Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 2015, 13(1): 306. | Cancer, Glioblastoma | Genomic profiling of MET-inhibitor sensitive glioblastoma cell lines | BLI | Mouse | Ami HT | Qian Xie, Van Andel Research Institute, Grand Rapids, MI, USA | 2015 | | Genetic profiling of MET-inhibitor sensitive glioblastomas: elevated Hepatocyte Growth Factor (HGF) expression correlated with MET-inhibitor efficacy, Probe: luciferase | cancer glioblastoma | genomic-profiling-of-met-inhibitor-sensitive-glioblastoma-cell-lines |
Jeffery, J.J., et. al., Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 2014, 239(4): 404–413. | Breast Cancer, Cancer | Breast cancer bone metastases prevention | BLI, uCT | Mouse | Ami HT | Setsuko K Chambers, University of Arizona Cancer Center, Tucson, AZ, USA | 2014 | | Breast Cancer Bone Metastases Prevention: c-fms proto-oncogene, osteolysis, autocrine, polyclonal anti-human c-fms antibody, Probe: luciferase | breast-cancer cancer | breast-cancer-bone-metastases-prevention |
Ippen, F.M., et. al., The dual PI3K/mTOR pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2019, 25(11): 3374–3383. | Breast Cancer, Cancer | Breast cancer brain metastases treatment | BLI | Mouse | Ami HTX | Priscilla K. Brastianos, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA | 2019 | | Breast Cancer Brain Metastases Treatment: GDC-0084, dual PI3K/mTOR inhibitor , Probe: luciferase | breast-cancer cancer | breast-cancer-brain-metastases-treatment |
Hudson, S.V., et. al., Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer Research, 2014, 74(21): 6271–6279. | Cancer, Pancreatic Cancer | Pancreatic cancer specific NIR fluorescent probe | BLI, FLI | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2014 | | Pancreatic Cancer: Epidermal growth factor receptor (EGFR), targeted by EGF-CF750 conjugate probe, detected by FLI or multispectral optoacoustic tomography (MSOT), luciferase-transduced S2VP10L tumors, Probes: CF-750, luciferase | cancer pancreatic-cancer | pancreatic-cancer-specific-nir-fluorescent-probe |
Huang, J., et. al., An activatable near-infrared chromophore for multispectral optoacoustic imaging of tumor hypoxia and for tumor inhibition, Theranostics, 2019, 9(24):7313-7324. | Cancer, Tumor Hypoxia | Hypoxia-specific NIR activateable probe conjugated to DNA-binding therapeutic | FLI | Mouse | Ami HT | Fang Zeng, and Shuizhu Wu, South China University of Technology, Guangzhou, China | 2019 | | Tumor hypoxia: Liposome encapsulated, combined NIR fluorophore probe and DNA-binding therapeutic, nitrogen mustard, are activated by hypoxia-associated reductases , Probe: NR-NH2, an amino-containing xanthene fluorophore | cancer tumor-hypoxia | hypoxia-specific-nir-activateable-probe-conjugated-to-dna-binding-therapeutic |
Huang, D., et. al., Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle. Acta Biomaterialia, 2020. | Duchenne muscular dystrophy (DMD) | Muscle growth and repair | FLI | Mouse | Ami HT | Feng Yue, and Shihuan Kuang, Purdue University, West Lafayette, IN , USA | 2020 | | Duchenne muscular dystrophy (DMD) treatment: Normalizing muscle growth and repair, phosphatase and tensin homolog (PTEN) inhibitors, nanoparticles (NP), muscle homing peptide, M12, Probe: Alexa Fluor 488 | duchenne-muscular-dystrophy-dmd | muscle-growth-and-repair |
Hipsch, M., et. al., Sensing stress responses in potato with whole-plant redox imaging. Plant Physiology, 2021. | Radical Oxygen Species (ROS) | Plant Oxidative Stress | FLI | Potato Plant (cv. Desiree) | Ami HT | Shilo Rosenwasser, The Hebrew University of Jerusalem, Rehovot, Israel | 2021 | | Radical oxygen species (ROS) production during Environment Stress Conditions: Hydrogen peroxide levels detected by chloroplast associated, glutathione redox potential, in turn, measured by redox sensitive GFP (roGFP2), in Solanum tuberosum potato, environmental stressors tested: temperature, light exposure, drought, Probe: roGFP2 | radical-oxygen-species-ros | plant-oxidative-stress |
Heo, R., et. al., Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis, Biomaterials, 2017. | Autoimmunity, Rheumatoid Arthritis | Therapeutic delivery by Nanoparticles | FLI | Mouse | Ami HT | Jae Hyung Park, Sungkyunkwan University, Suwon, Republic of Korea | 2017 | | Rheumatoid Arthritis Treatment: dextran sulfate nanoparticles, methotrexate therapeutic, taken up by activated macrophages (via scavenger receptor class A endocytosis) at sites of RA joint inflammation, Probe: FPR-675 | autoimmunity rheumatoid-arthritis | therapeutic-delivery-by-nanoparticles |
Henry, M.D., et. al., Comparison of high sensitivity BLI imaging systems for ultra-weak signal applications. (Conference poster). | Bioluminescent Imaging | Signal calibration across field of view (FOV) | BLI | Mouse | Ami HTX | 1-Michael D. Henry, and 2-Michael D. Cable, 1-University of Iowa Carver College of Medicine, Iowa City, IA, USA, and 2-Spectral Instruments Imaging, Tucson, AZ, USA | na | | Bioluminescent Imaging Devices: normalizing light collection efficiency across FOV, light optics, flat field corrections in Spectral Instruments Imaging vs. IVIS systems, Probe: luciferase | bioluminescent-imaging | signal-calibration-across-field-of-view-fov |
Hardy, S.D. et. al., Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 2017, 8(61): 103302–103314. | Breast Cancer, Cancer | Molecular Biology of Epithelial Mesenchymal transition (EMT) | BLI | Mouse | Ami HT | Michael K. Wendt and Robert L. Geahlen, Purdue University, West Lafayette, IN , USA | 2017 | | Breast Cancer: Processing bodies (P-bodies), stress associated post-transcriptional mRNA metabolism, cleared by autophagy, but accumulates with expression of transforming growth factor-beta (TGF-β) leading to epithelial-mesenchymal transition (EMT), DDX6 inhibition blocks P-body formation and EMT, Probe: luciferase | breast-cancer cancer | molecular-biology-of-epithelial-mesenchymal-transition-emt |
Han, N., et. al., Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics, 2017, 14(5): 1538–1547. | Nanoparticle delivery systems | NP targeting of tumor microenvironment (TME) | FLI | Mouse | Ami HT | Yoon Yeo, Purdue University, West Lafayette, IN , USA | 2017 | | Tumor targeting Nanoparticles (NPs): coated with amidated TAT peptides, accumulate in acidic tumor microenvironment (TME), due to TAT carboxy residue formation ("activation"), mouse in vivo studies fail due to premature activation not seen in vitro, Probe: DiR | nanoparticle-delivery-systems | np-targeting-of-tumor-microenvironment-tme |
Haber, Z., et. al., Resolving diurnal dynamics of the chloroplastic glutathione redox state in Arabidopsis reveals its photosynthetically-derived oxidation, The Plant Cell, 2021. | Radical Oxygen Species (ROS) | Plant Oxidative Stress | FLI | Arabidopsis | Ami HT | Shilo Rosenwasser, The Hebrew University of Jerusalem, Rehovot, Israel | 2021 | | Plant oxidative stress: ROS, chloroplastic glutathione redox potential (chl-EGSH), light-dark, dark-light transitions, protection of photosystem I (PSI) and phoytosystem II PSII) from photoinhibition, Probe: roGFP2 | radical-oxygen-species-ros | plant-oxidative-stress |
Feng, X., et. al., Responsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals. Chemistry, An Asian Journal, 2018, 10.1002/asia.201800957 | Radical Oxygen Species (ROS) | ROS detection by fluorescence imaging | FLI | Zebra Fish; Mouse | Ami HT | 1-Qingtao Meng, and 2-Run Zhang, 1-University of Science and Technology, Liaoning, Anshan, China and 2-The University of Queensland, Brisbane, Australia. | 2018 | | Reactive Oxygen Species (ROS) Detection: HOCl detection, zebra and mouse models, novel fluorophore, Probe: PQI | radical-oxygen-species-ros | ros-detection-by-fluorescence-imaging |
Feng, X., et. al., Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 2017, 385: 12–20. | Cancer, Glioblastoma | re-angiogenesis, Tumor recurrence | BLI | In vitro; Mouse | Ami HTX | 1-Chuan-Yuan Li, 2-Ling Tian, and 2-Qian Huang, 1-Duke University Medical Center, Durham, NC, USA, and 2-Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China | 2017 | | Glioblastoma: Tumor recurrence, re-angiogenesis, Caspase 3 dependent, molecular mechanisms, COX-2/PGE2, VEGF-A, Probe: luciferase | cancer glioblastoma | re-angiogenesis tumor-recurrence |
Fan, Q., et. al., Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy, Journal of Controlled Release, 2019, 302: 63-78. | Cancer, Sarcoma | Tumor vascular normalization | FLI | Mouse | Lago X | Jingqiu Cheng, and Xiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China | 2019 | | Sarcoma: tumor vascular normalization, cancer-targeted therapy, pericytes, TNFα, affibody, doxorubicin, Probe: CF-750 succinimidyl ester | cancer sarcoma | tumor-vascular-normalization |
England, C.G., et. al., Detection of phosphatidylcholine-coated gold nanoparticles in orthotopic pancreatic adenocarcinoma using hyperspectral imaging. PloS one, 2015, 10(6). | Cancer, Pancreatic Cancer | Nanoparticle intra-tumoral penetration | BLI | Mouse | Ami HTX | Hermann B. Frieboes, University of Louisville, Louisville, KY, USA | 2015 | | Gold Nanoparticle (NP) Intratumoral Transport Barriers: interstitial fluid pressure (IFP), chaotic and dense extracellular matrix, acidic micro-environment in orthotopic pancreatic adenocarcinoma (PAC). Penetration improved by: reduced NP size, phosphatidylcholine-coating (vs. PEG coating); detection by hyperspectral imaging, Probe: luciferase | cancer pancreatic-cancer | nanoparticle-intra-tumoral-penetration |
England, C.G., et. al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor. (Conference poster). | XRAY Imaging | Animal safety, Oncogenesis | BLI, XRAY | Mouse | Ami HTX | Lacey R. McNally, University of Louisville, Louisville, KY, USA | na | | Safety of in vivo X-Ray Imaging: Oncogenesis, Pancreatic Cancer, Probe: luciferase | xray-imaging | animal-safety oncogenesis |
Elattar, S., et. al., The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. The FASEB Journal, 2018, 32: 4727–4743. | Cachexia | Cachexia molecular, therapeutic target | FLI | Mouse | Ami HT | Ande Satyanarayana, Augusta University, Augusta, Georgia, USA | 2018 | | Cachexia: tissue-wasting syndrome characterized by inflammation, hyper metabolism, increased energy expenditure, and anorexia. Zinc-α2-glycoprotein (ZAG) as a therapeutic target, beige adipocyte, Ebf2, Prdm16, Ucp1, Probe: Td-Tomato | cachexia | cachexia-molecular therapeutic-target |
Dykstra, M., et. al., In vitro and in vivo studies of cerenkov luminescence imaging. (Conference poster). | Cerenkov Imaging | Cerenkov Imaging with Optical Imager | BLI | Mouse | Ami HT | Michael Dykstra, Grand Valley State University, Allendale, MI, USA, and Van Andel Research Institute,Grand Rapids, MI, USA | na | | Cerenkov Luminescence Imaging: positron, positron emission tomography (PET), Probe: 18F-FDG | cerenkov-imaging | cerenkov-imaging-with-optical-imager |
Dassie, J.P., et. al., Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 2014, 22(11): 1910–1922. | Cancer, Pancreatic Cancer | Metastases Inhibition | BLI, FLI | Mouse | Ami HT | Paloma H. Giangrande, University of Iowa, Iowa City, IA, USA | 2014 | | Pancreatic Cancer, bone metastases: Tumor-targeting smart drugs, RNA Aptamer (A9g), inhibitor of prostate-specific membrane antigen (PSMA), Probes: luciferase, IRDye 800CW | cancer pancreatic-cancer | metastases-inhibition |
Dann, T., et. al., Anatase titanium dioxide imparts photoluminescent properties to PA2200 commercial 3D printing material to generate complex optical imaging phantoms. Materials, 2021, 14(7): 1813. | Imaging Phantoms | Photoluminescent 3D-print phantoms | PL | Optical Phantoms | Ami HT | W. Matthew Leevy, University of Notre Dame, 1234 N Notre Dame Avenue, South Bend, IN, USA | 2021 | | Optical Imaging Phantoms: Selective laser sintering, 3D-printed, nylon 12 and titanium dioxide (TiO2), photoluminescence, rat anatomical phantom, derenzo phantom, Probe: TiO2 | imaging-phantoms | photoluminescent-3d-print-phantoms |
Connolly, R.J., et. al., Development of a catheter-based applicator for immuno-oncology. (Conference Poster). | Cancer, Melanoma | Immunotherapy | BLI | Mouse | Lago | Robert H. Pierce, OncoSec Medical Incorporated, San Diego, CA, USA | na | | Melanoma: Immuno-oncology, immunotherapy, electroporation, catheter, intratumoral delivery of cytokine encoding plasmids, IL-12, Probe: luciferase | cancer melanoma | immunotherapy |
Chaurasiya, S., et. al., Toward comprehensive imaging of oncolytic viroimmunotherapy, Molecular Therapy: Oncolytics, 2021 | various | Viral oncolytic therapy | BLI | various | Lago X | Susanne Warner, City of Hope National Medical Center, Duarte, CA, USA | 2021 | | Viral Oncolytic Therapy: tumor micro environment (TME), viroimmunotherapy, Probe: luciferase | various | viral-oncolytic-therapy |
Buchakjian, M.R., et al., Development of a Tongue Carcinoma Model Using Real-Time In Vivo Molecular Monitoring. (Conference Poster). | Cancer, Sarcoma | Oncogenesis | BLI | Mouse | Ami HTX | Michael D. Henry, University of Iowa Carver College of Medicine, Iowa City, IA, USA | na | | Tongue Carcinoma: adenovirus CRE recombinase, TP53/PTEN knockout / luc knockin, Probe: luciferase | cancer sarcoma | oncogenesis |
Buchakjian, M.R., et. al., A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS One, 2017, 12(8). | Cancer, Sarcoma | Oncogenesis | BLI | Mouse | Ami HTX | Michael D. Henry and Christopher S. Stipp, University of Iowa Hospitals & Clinics, and University of Iowa Carver College of Medicine, Iowa City, IA,USA | 2017 | | Sarcoma: adenovirus CRE recombinase, TP53/PTEN knockout / luc knockin, Probe: luciferase | cancer sarcoma | oncogenesis |
Borin, T.F., et. al., HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS One, 2017, 12(6). | Breast Cancer, Cancer | Immunotherapy | BLI | Mouse | Ami HTX | Ali S. Arbab, Augusta University, Augusta, GA, USA | 2017 | | Breast Cancer: T41 cells, lung metastases, immunosuppression, myeloid-derived suppressor cells (MDSC), tumor microenvironment (TME), selective inhibitor of 20-HETE synthesis, Probe: luciferase | breast-cancer cancer | immunotherapy |
Bhutiani, N., et. al., Detection of microspheres in vivo using multispectral optoacoustic tomography. Biotech Histochemistry, 2017, 92(1): 1–6. | Nanoparticles (NPs) | NIRF labeling of NPs | FLI | Mouse | Ami HT | Lacey R. McNally, University of Louisville, Louisville, KY, USA | 2017 | | Microsphere particle delivery system: liver, optoacoustic tomography, Probe: IR-780-iodide | nanoparticles-nps | nirf-labeling-of-nps |
Bahrami, A.J., et. al., A novel approach for endoscopic gene transfer. (Conference Poster), 2017. | Cancer, Melanoma | Immunotherapy | BLI | Mouse | Lago | Robert H. Pierce,OncoSec Medical Incorporated, San Diego, CA, USA | 2017 | | Melanoma: intratumoral gene therapy, electroporation, IL-12, Probe: luciferase | cancer melanoma | immunotherapy |
Au, K.M., et. al., Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin’s lymphoma. Science Advances, 2020, 6: 1-12. | Cancer, Non-Hodgkin's Lymphoma | B Cell Receptor transduction cascade regulation | FLI | Mouse | Ami HT | Steven I. Park, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA | 2020 | | Non-Hodgkin's Lymphoma (NHL): B Cell receptor transduction cascade, dual PI3K/mTOR inhibitor, delivered by antibody-predirected nanoparticles, , Probe: Cy5 | cancer non-hodgkins-lymphoma | b-cell-receptor-transduction-cascade-regulation |
Alizadeh, D., et. al., INFɣ is Critical for CAR T cell mediated myeloid activation and induction of endogenous immunity. Cancer Discovery, 2021, 11(9): 2248-2265. | Cancer, Glioblastoma | Immunotherapy | BLI | Mouse | Ami HT | Christine E. Brown, City of Hope National Medical Center, Duarte, CA, USA | 2021 | | Glioblastoma (GBM): chimeric antigen receptor (CAR) T cells, IFNγ, tumor microenvironment, myeloid cells, endogenous memory T cells, Probe: luciferase | cancer glioblastoma | immunotherapy |
Alizadeh, D., et. al., Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 2014, 74(1): 104–118. | Breast Cancer, Cancer | Immunotherapy | BLI | Mouse | Ami HT | Nicolas Larmonier, University of Arizona, Tucson, Arizona, USA | 2014 | | Breast Cancer: Myeloid-derived suppressor cells (MDSC), immunotherapy, doxorubicin, Th1, Th17, Probe: luciferase | breast-cancer cancer | immunotherapy |
Alexander, M.S., et. al., A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. Journal of Biological Methods, 2018, 5(3): 1-7. | Cancer, Pancreatic Cancer | Metastases formation | BLI | Mouse | Ami HT | Michael D. Henry, and Joseph J. Cullen, University of Iowa College of Medicine, Iowa City, USA | 2018 | | Pancreatic ductal adenocarcinoma (PDAC): circulating tumor cells (CTCs), metastasis, orthotopic implantation, Probes: luciferase, GFP | cancer pancreatic-cancer | metastases-formation |
Achyut, B.R., et. al., Chimeric mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 2016, 17(3): 280–290. | Cancer, Pancreatic Cancer | Antiangiogenic resistance | FLI | Mouse | Ami HT | Ali S. Arbab, Georgia Regents University, Augusta, GA, USA | 2016 | | Glioblastoma (GBM): tumor antiangiogenic resistance, tumor microenvironment, bone marrow, vascular endothelial growth factor (VEGF), Probe: GFP | cancer pancreatic-cancer | antiangiogenic-resistance |
Achyut, B.R., et. al., Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 2015, 369(2): 416–426. | Cancer, Glioblastoma | Antiangiogenic resistance | FLI | Mouse | Ami HT | Ali S. Arbab, Georgia Regents University, Augusta, GA, USA | 2015 | | Glioblastoma (GBM): tumor antiangiogenic resistance, tumor microenvironment, bone marrow, vascular endothelial growth factor (VEGF), Probes: GFP, mCherry Red | cancer glioblastoma | antiangiogenic-resistance |