| Publication Reference | General Research Category | Specific Research Category | Modality | Model | System | Corresponding Authors And Institution | Date | Link | Key Summary | hf:doc_categories | hf:doc_tags |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Madhurima, G., Sanjeez, D. PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis. 2021. Vol 118 No. 40. | Tumorigebesis | Ubiquitylation | BLI | Mouse | Lago X | Sanjeev Dasa, Molecular Oncology Laboratory, National Institute of Immunology, New Delhi 110067, India | 2021 | Delineated PRAMEF2 regulation under low-nutrient conditions. Also showed that it promotes proteasomal degradation of LATS1 kinase of the Hippo/YAP pathway. LATS1 downregulation triggers nuclear accumulation of the transcriptional coactivator YAP, which induces the expression of proliferative and metastatic genes. Thus, PRAMEF2 promotes malignant phenotype in a YAP-dependent manner. Taken together, the findings reveal a pivotal role for PRAMEF2 in determining YAP oncogenic signaling, which has key implications for tumorigenesis. | tumorigebesis | ubiquitylation | |
| Hu, X. et al. Gypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques | Immunology | Genetic engineering of allogenic cell therapeutics | BLI | Rhesus Macaques | Lago | Sonja Schrepfer, Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA 94080, USA | 2023 | Engineered rhesus macaque human hypoimmune pluripotent (HIP) cells and transplanted them intramuscularly into four allogeneic rhesus macaques. The HIP cells survived unrestricted for 16 weeks in fully immunocompetent allogeneic recipients and diferentiated into several lineages, whereas allogeneic wild-type cells were vigorously rejected | immunology | genetic-engineering-of-allogenic-cell-therapeutics | |
| Zhang, Q. et al. Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer. Pharmaceutics. 2022. 14, 510. | Cancer, Lung cancer | Nanomicelle-Microsphere Composite as a Drug Carrier | FLI | Mouse | Ami HT | Rongfeng Hu, Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Key Laboratory of Xin’an Medicine, the Ministry of Education, Anhui Province Key Laboratory of Chinese Medicinal Formula, Plant Active Peptide Function Food Innovative Manufacturing Industry Innovation Team, Anhui University of Chinese Medicine, Hefei 230038, China | 2022 | Developed a nanomicelle-microsphere composite, in which doxorubicin (DOX) was loaded with spermine (Spm) modified poly (ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) micelles, and then the nanomicelles were noncovalently adsorbed on the surface of poly (lactic-co-glycolic acid) (PLGA) microspheres. An orthotopic lung cancer implantation model based on C57BL/6 mice was established, and in vivo biodistribution studies confirmed that the complex improved the distribution of DOX in the lungs and displayed notable tumor targeting. Probe: DOX-loaded micelles. | cancer lung-cancer | nanomicelle-microsphere-composite-as-a-drug-carrier | |
| Jussi Taipale, 1 Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland | Diabetes | Type 1 Diabetes | BLI | Mouse | Ami HT | Sonja Schrepfer, Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA 94080, USA | 2023 | Editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47 overexpressing phenotype and their reaggregation into human HIP pseudoislets (p-islets). Human HIP p-islets were shown to survive, engraft, and ameliorate diabetes in immunocompetent, allogeneic, diabetic humanized mice. | diabetes | type-1-diabetes | |
| Biswajyoti, S. et al. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021, 40:5533–5547. | Cancer | Cancer Genetics | FLI | Mouse | Lago | Jussi Taipale, 1 Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland | 2021 | Combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. Reprogramming fibroblasts to a liver progenitor fate, induced hepatocytes (iHeps), makes them sensitive to transformation by the same oncogenes. Tumorigenesis is triggered by a combination of three elements: the set of driver mutations, the cellular lineage, and the state of differentiation of the cells along the lineage. Probe: mCherry. | cancer | cancer-genetics | |
| Amano, T. et al. Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity. iScience. 2023, 26,106335. | Pathogenic Coronaviruses | Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - SARS-CoV - Middle East respiratory syndrome coronavirus (MERS-CoV)" | BLI | Mouse | Ami HT | Minoru S.H. Ko, Elixirgen Therapeutics, Inc., Baltimore, MD, USA | 2022 | Developed an mRNA vaccine platform for skin delivery without nanoparticles. developed an srRNA that functions optimally at around 33C (skin temperature) and is inactivated at or above 37C (core body temperature) as a safety switch. This temperature-controllable srRNA (c-srRNA), when tested as an intradermal vaccine against SARS-CoV-2, functions when injected naked without lipid nanoparticles. | pathogenic-coronaviruses | acute-respiratory-syndrome-coronavirus-2-sars-cov-2-sars-cov-middle-east-respiratory-syndrome-coronavirus-mers-cov | |
| Karsten, L. et al. Bivalent EGFR-Targeting DARPin-MMAE Conjugates. International Journal of Molecular Sciences. 2022, 23: 2468. | Cancer, Squamous Cell Carcinoma and Glioma | Antibody-drug conjugates | FLI | Mouse | Lago | Kristian Muller, Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, 33615 Bielefeld, Germany | 2022 | Constructed protein-drug conjugates based on the anti-Epidermal growth factor receptor (EGFR). Designed Ankyrin Repeat Protein (DARPin) E01, and compared the bivalent DARPin dimer (DD1) and a DARPin-Fc (DFc) to the monomeric DARPin (DM) and the antibody derived scFv425-Fc (scFvFc) in cell culture and a mouse model. Probe: Alexa Fluor 647. | cancer squamous-cell-carcinoma-and-glioma | antibody-drug-conjugates | |
| Park, S. et al. Bioluminescence Imaging of Matrix Metalloproteinases-2 and -9 Activities in Ethanol-injured Cornea of Mice. in vivo. (2021) 35: 1521-1528. | Ethanol-induced damage in the cornea of mice | Role of matrix metalloproteinases (MMP)-2 and MMP-9 activation | BLI | Mouse | Ami HTX | Kyung-Jong Won, Department of Physiology, Konkuk University School of Medicine, Seoul, Republic of Korea | 2021 | BLI can be applied in vivo in mice with corneal injury to examine the activity of MMPs and clarify the efficacy of eye drops. | ethanol-induced-damage-in-the-cornea-of-mice | role-of-matrix-metalloproteinases-mmp-2-and-mmp-9-activation | |
| Andradas, C. et al. Assessment of Cannabidiol and Δ9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma. Cancers (Basel). 2021 Jan 18;13(2):330. | Cancer, Medullablastoma | Assessment of Cannabidiol and ∆9-Tetrahydrocannabiol | BLI | Mouse | Lago X | Clara Andradas, Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA 6009, Australia. | 2021 | Cannabinoids had cytotoxic activity against medulloblastoma and ependymoma cells in vitro, functioning in part through the inhibition of cell cycle progression and the induction of autophagy. Despite these effects in vitro, when tested in orthotopic mouse models of medulloblastoma or ependymoma, no impact on animal survival was observed. | cancer medullablastoma | assessment-of-cannabidiol-and-%e2%88%869-tetrahydrocannabiol | |
| Lopez-Pier, M., et al. An adaptable and non-invasive method for tracking Bifidobacterium animalis subspecies lactis 420 in the mouse gut. J Microbial Methods, 2021, 189: 106302 | Gut Microbiota | Tracking bacteria in the gut | FLI | Mouse | Lago X | John Konhilas, Department of Physiology, University of Arizona, Tucson, AZ | 2021 | Labeling of microbial species with an externally detectable marker allows detection as to their specific geographic residence/location during transit through the gut. Incubated B420 with common, FDA-approved contrast agents, ISOVUE-300 or indocyanine green (ICG), and visualized by x-ray fluoroscopy (ISOVUE-300) or fluorescence (ICG) along the GI tract at different timepoints. Validated and quantified B420 using quantitative PCR at different regions of the GI tract. ICG was a more effective labeling agent over ISOVUE-300. Probe: Indocyanine green (ICG). | gut-microbiota | tracking-bacteria-in-the-gut | |
| Choi, J., et al. A unique subset of glycolytic tumor propagating cells drives squamous cell carcinoma. Nat. Metab. 2021. 3(2): 182–195. | Cancer, Head and Neck Squamous Cell Carcinoma | Tumor progression | BLI | Mouse | Ami HTX | Raul Mostoslavsky, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA | 2021 | Defined a subset of Tumor Propagating Cells (TPCs) as exhibiting increased glutathione (GSH) and provided strong in vivo data for the importance of increased glycolysis in generating glutathione and defending against oxidative stress. Discovered a unique “metabolic heterogeneity” within TPCs, indicating that only a defined (previously unknown) subpopulation of CD34+ TPCs acquires metabolic adaptations that could drive tumorigenesis | cancer head-and-neck-squamous-cell-carcinoma | tumor-progression | |
| Abramson, A., et al. A flexible electronic strain sensor for the real-time monitoring of tumor regression. Science Advances, 2022, 8, eabn6650 | Cancer, Lung cancer | Tumor size monitoring | BLI | Mouse | Lago X | Zhenan Bao, 1 Department of Chemical Engineering, Stanford University, Stanford, CA | 2022 | Commercially scalable wearable electronic strain sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring the micrometer-scale progression or regression of subcutaneously implanted tumors at the minute time scale. Regression measurements were validated through histology, and caliper and bioluminescence measurements | cancer lung-cancer | tumor-size-monitoring | |
| Yang, F., et al. A biomineral-inspired approach of synthesizing colloidal persistent phosphors as a multicolor, intravital light source. Science Advances, 2022, 8, eabo6743 | Optics | Nanophosphor Development | FLI | Mouse | Lago X | Guosong Hong, Department of Materials Science and Engineering, Stanford University, Stanford, CA | 2022 | Bioinspired demineralization (BID) strategy to synthesize stable colloidal solutions of solid-state phosphors in the range of 470 to 650 nm and diameters down to 20 nm. The exceptional brightness of BID-produced colloids enables their utility as multicolor luminescent tags in vivo with favorable biocompatibility. Because of their stable dispersion in water, BID-produced nanophosphors can be delivered systemically, acting as an intravascular colloidal light source to internally excite genetically encoded fluorescent reporters within the mouse brain. Probe: nanophosphor colloid | optics | nanophosphor-development | |
| Zhong, Y., et. al., Co-administration of of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment. International Journal of Nanomedicine, 2019, 14: 8543–8560. | Cancer, Colorectal Cancer | Nanoparticle (NP) therapeutic delivery for colorectal cancer: | cancer colorectal-cancer | nanoparticle-np-therapeutic-delivery-for-colorectal-cancer | |||||||
| Zhong, Q., et. al., Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters, Biomaterials, June 2020, 206: 73-86. | Therapeutic Drug Delivery | Ultrasound-activated drug-loaded nanoemulsions | therapeutic-drug-delivery | ultrasound-activated-drug-loaded-nanoemulsions | |||||||
| Zeiderman, M.R., et. al., Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2016, 2(7), 1108–1120. | Cancer, Pancreatic Cancer | Pancreatic tumor detection and treatment with novel theranostic particles | cancer pancreatic-cancer | pancreatic-tumor-detection-and-treatment-with-novel-theranostic-particles | |||||||
| Yuan, G., et. al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, 2021, 590(7846), 504-508. | Cancer, Lung cancer | Lung squamous cell carcinoma (LUSC) tumorigenesis | cancer lung-cancer | lung-squamous-cell-carcinoma-lusc-tumorigenesis | |||||||
| Yoon, H.Y., et. al., Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 2014, 4(1), 6878. | Cancer, Prostate Cancer | Glycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehicles | cancer prostate-cancer | glycol-chitosan-nanoparticles-cnps-as-specialized-cancer-therapeutic-vehicles | |||||||
| Yong, C., et. al., Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 2020, 15(9). | Cancer, Prostate Cancer | Castration resistant invasive prostate cancer | cancer prostate-cancer | castration-resistant-invasive-prostate-cancer | |||||||
| Yin, W., et. al., Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences, Senior Honors Theses, 2016, Paper 126. | Cancer, Pancreatic Cancer | Directed-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinoma | cancer pancreatic-cancer | directed-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma | |||||||
| Yin, W., et. al., Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography, Journal of Nanobiotechnology, 2015, 13:90. | Cancer, Pancreatic Cancer | Directed-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinoma | cancer pancreatic-cancer | directed-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma | |||||||
| Yang, H., et. al., Endogenous IgG-based affinity-controlled release of TRAIL exerts superior antitumor effects, Theranostics, 2018, 8(9): 2459-2476. | Cancer, Colorectal Cancer | TRAIL in vivo pharmacokinetics optimized for superior antitumor efficacy | cancer colorectal-cancer | trail-in-vivo-pharmacokinetics-optimized-for-superior-antitumor-efficacy | |||||||
| Yadav, S., et. al., MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 2017, Vol. 19, No. 4, pp. 321-332 | Cancer, Lung cancer | miRNA-mediated loss of Ubiquilin protein expression | cancer lung-cancer | mirna-mediated-loss-of-ubiquilin-protein-expression | |||||||
| Wu, B., et. al., Oligo(ethylene glycol)-functionalized squaraine fluorophore as a near-infrared-fluorescent probe for the in vivo detection of diagnostic enzymes. Analytical Chemistry, 2018, 90:9359-9365. | Cancer, Liver Cancer | In vivo detection of tumor-associated diagnostic enzymes | cancer liver-cancer | in-vivo-detection-of-tumor-associated-diagnostic-enzymes | |||||||
| Wen, F., et. al., Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 2013, 73(14), pp.4256–4266. | Cancer, Pancreatic Cancer | Extracellular DNA promotes tumor-associated inflammation; cell invasion and aggressive metastasis | cancer pancreatic-cancer | extracellular-dna-promotes-tumor-associated-inflammation-cell-invasion-and-aggressive-metastasis | |||||||
| Watson, J.R., et.al., Intraoperative imaging using intravascular contrast agent. Society of Photo-Optical Instrumentation Engineers, Conference Proceedings, 2016, Vol.9696. | Cancer, Glioblastoma | Intraoperative tumor detection | cancer glioblastoma | intraoperative-tumor-detection | |||||||
| Varzavand, A., et. al., α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer Research, 2016, 76(22), 6577–6587. | Cancer, Prostate Cancer | Prostate cancer metastasis regulation | cancer prostate-cancer | prostate-cancer-metastasis-regulation | |||||||
| Tao, Z., et. al., Targeted delivery to tumor-associated pericytes via an affibody with high affinity for PDGFRβ enhances the in vivo antitumor effects of human TRAIL. Theranostics, 2017, 7(8): 2261-2276. | Cancer, Colon Cancer | Tumor-targeted hTRAIL therapy | cancer colon-cancer | tumor-targeted-htrail-therapy | |||||||
| Tang, A.C., et. al. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. Cell Death and Disease, 2018, 9:162. | Cancer, haematological malignancies | Combination therapy of proteasome inhibitors and Toll-like receptor agonists | cancer haematological-malignancies | combination-therapy-of-proteasome-inhibitors-and-toll-like-receptor-agonists | |||||||
| Sukumar, U.K., et. al., SP94-targeted triblock copolymer nanoparticle delivers thymidine kinase-p53-nitroreductase triple therapeutic gene and restores anticancer function against hepatocellular carcinoma in vivo. ACS Applied Material Interfaces, March 2020, 12(10): 11307-11319. | Cancer, Hepatocellular Carcinoma | Gene-directed enzyme–prodrug therapy (GDEPT) | cancer hepatocellular-carcinoma | gene-directed-enzyme-prodrug-therapy-gdept | |||||||
| Sukumar, U.K., et. al., Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to Temozolomide. Biomaterials, October 2019, 218. | Cancer, Glioblastoma | Theranostic; intranasal and systemic combinatorial therapy of GBM | cancer glioblastoma | theranostic-intranasal-and-systemic-combinatorial-therapy-of-gbm | |||||||
| Suhardi, V.J., et. al., A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. Nat Biomed Eng. 2017, 1. | Revision of Infected Prosthetic Joints | Antibiotic drug delivery and mechanical strength of prosthetic joint implant material | revision-of-infected-prosthetic-joints | antibiotic-drug-delivery-and-mechanical-strength-of-prosthetic-joint-implant-material | |||||||
| Su, Y., et. al., Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals, Nature Methods, 2020, 17, 852–860. | Bioluminescent Imaging | Dual Bioluminescence Imaging | bioluminescent-imaging | dual-bioluminescence-imaging | |||||||
| Stokes, J., et. al., Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 2016, 174(1), 102–116. | Cancer, Lymphoma | GVHD prevention and GVL preservation | cancer lymphoma | gvhd-prevention-and-gvl-preservation | |||||||
| Song, J.H. & Kraft, A.S., Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 2016, 76(s14), 4414–4414. | Cancer, Lymphomas | Pim Kinase substrates and associated regulatory pathways | cancer lymphomas | pim-kinase-substrates-and-associated-regulatory-pathways | |||||||
| Shin, J.M., et. al., A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy. Biomaterials Research, 2018, 22:21. | Cancer, Cervical Cancer | Immunotherapy by polymeric antigen carrier | cancer cervical-cancer | immunotherapy-by-polymeric-antigen-carrier | |||||||
| Shi, Q., et. al., PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 2017, 24(1), pp.1818–1830. | Cancer, Colorectal Cancer | Photodynamic therapy | cancer colorectal-cancer | photodynamic-therapy | |||||||
| Shankar, G.M., et. al., Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(36), E8388–E8394. | Cancer, Glioblastoma | Genotype-targeted therapy | cancer glioblastoma | genotype-targeted-therapy | |||||||
| Schüler, E., et. al., Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 2017, 97(1), 195–203. | Cancer, Radiation Oncology | protocol development, Ultra-high dose rate irradiation (>50 Gy/s “FLASH”) | cancer radiation-oncology | protocol-development ultra-high-dose-rate-irradiation-50-gy-s-flash | |||||||
| Samykutty, A., et. al., Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging. Biotech Histochemistry, 2018, 93(8), 608-614. | Breast Cancer, Cancer | Detection and monitoring of breast cancer by a osteopontin-NIR fluorophore conjugate | breast-cancer cancer | detection-and-monitoring-of-breast-cancer-by-a-osteopontin-nir-fluorophore-conjugate | |||||||
| Rice, M.A., et. al., Loss of Notch1 activity inhibits prostate cancer growth and metastasis and sensitizes prostate cancer cells to antiandrogen therapies. Molecular Cancer Therapeutics, 2019, 18(7): 1230–1242. | Cancer, Prostate Cancer | NOTCH1 and Notch1 activity as therapeutic targets of aggressive prostate cancer | cancer prostate-cancer | notch1-and-notch1-activity-as-therapeutic-targets-of-aggressive-prostate-cancer | |||||||
| Qiu, X.Y., et. al., PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. BBA – Molecular Basis of Disease, 2018, 1864: 1754-1769 | Cancer, Glioblastoma | Programmed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme malignancy | cancer glioblastoma | programmed-cell-death-ligand-1-pd-l1-expression-level-correlated-with-glioblastoma-multiforme-malignancy | |||||||
| Phuong, P.T.T., et. al., Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy. Colloids and Surfaces B: Biointerfaces, 2018, 171: 123-133. | Breast Cancer, Cancer | Breast tumor ablation by photodynamic therapy | breast-cancer cancer | breast-tumor-ablation-by-photodynamic-therapy | |||||||
| Park, S.B., et. al., Bioluminescence imaging of matrix metalloproteinases-2 and -9 activities in ethanol-injured cornea of mice. In vivo, 2021, 35: 1521-1528. | Eye Corneal Injury and Healing | Non-invasive monitoring eye corneal injury and healing | eye-corneal-injury-and-healing | non-invasive-monitoring-eye-corneal-injury-and-healing | |||||||
| Park, S., et. al., Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation. Journal of Controlled Release, 2019, 304: 7-18. | Cancer, Colon Cancer | Tumor Detection and Ablation by hybrid gold nanoclusters (AuNCs) | cancer colon-cancer | tumor-detection-and-ablation-by-hybrid-gold-nanoclusters-auncs | |||||||
| Park, J., et. al., Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceuticals, 2019 May, 16(5): 1864-1873. | Breast Cancer, Cancer | Improving NP delivery to tumor micro environment (TME) | breast-cancer cancer | improving-np-delivery-to-tumor-micro-environment-tme | |||||||
| Pandurangi, R.S., et. al., A priori activation of apoptosis pathways of tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment, PLoS ONE, 2021, 16(2). | Cancer, various | A priori activation of apoptosis pathways of tumor technology (AAAPT) | cancer various | a-priori-activation-of-apoptosis-pathways-of-tumor-technology-aaapt | |||||||
| Padi, S.K.R., et. al., Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 2017, 77(s13): 5820–5820. | Cancer, T-cell Acute Lymphoblastic Leukemias | pan-PIM Protein Kinase Inhibitor and Ponatinib vs.T-cell acute lymphoblastic leukemia subgroup | cancer t-cell-acute-lymphoblastic-leukemias | pan-pim-protein-kinase-inhibitor-and-ponatinib-vs-t-cell-acute-lymphoblastic-leukemia-subgroup | |||||||
| O’Leary, M.P., et. al., Novel oncolytic chemeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose. Journal of Translational Medicine, 2018, 16:110. | Cancer, Pancreatic Cancer | Oncolytic viral therapy vs. Pancreatic Cancer | cancer pancreatic-cancer | oncolytic-viral-therapy-vs-pancreatic-cancer | |||||||
| O’Leary, M.P., et. al., A novel oncolytic chimeric orthopoxvirus encoding luciferase enable real-time view of colorectal cancer cell infection. Molecular Therapy Oncolytics, June 2018, 9: 13-21. | Cancer, Colorectal Cancer | Oncolytic viral therapy vs. Colorectal Cancer | cancer colorectal-cancer | oncolytic-viral-therapy-vs-colorectal-cancer | |||||||
| O’Leary, B.R., et. al., Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 2020, 10: 17649 | Cancer, Pancreatic Cancer | Pharmacological ascorbate treatment of pancreatic ductal adenocarcinoma (PDAC) | cancer pancreatic-cancer | pharmacological-ascorbate-treatment-of-pancreatic-ductal-adenocarcinoma-pdac | |||||||
| O’Leary, B.R., et. al., Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma, AARC, Clinical Cancer Research, January 29, 2015. | Cancer, Pancreatic Cancer | Extracellular Superoxide Dismutase (SOD) as therapeutic target for treatment of pancreatic adenocarcinoma (PDA) | cancer pancreatic-cancer | extracellular-superoxide-dismutase-sod-as-therapeutic-target-for-treatment-of-pancreatic-adenocarcinoma-pda | |||||||
| Nishihara, R., et. al., Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo. Theranostics, 2019, 9(9): 2646-2661. | Breast Cancer, Cancer | NIR-BRET probes for in vivo monitoring of tumor metastases, protein-protein interactions | breast-cancer cancer | nir-bret-probes-for-in-vivo-monitoring-of-tumor-metastases protein-protein-interactions | |||||||
| Moose, D.L., et. al., Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 2020, 30: 1-11. | Cancer, Prostate Cancer | Mechanism of Resilience of circulating tumor cells (CTCs) | cancer prostate-cancer | mechanism-of-resilience-of-circulating-tumor-cells-ctcs | |||||||
| Meng, F., et. al., Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited, ACS Nano, 2018, July 24, 12(7): 6458-6468. | Fluorescence Imaging | Fluorescence signal quenching in fluorophore-loaded nanoparticles | fluorescence-imaging | fluorescence-signal-quenching-in-fluorophore-loaded-nanoparticles | |||||||
| Marecic, O., et al., Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 2015, 112(32): 9920–9925. | Bone Growth, Repair | cartilage, Distinct gene expression and phenotype of fracture-induced bone, stromal progenitor (f-BCSP) cells | bone-growth repair | cartilage distinct-gene-expression-and-phenotype-of-fracture-induced-bone stromal-progenitor-f-bcsp-cells | |||||||
| Marchal, M.A., et. al., Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis. bioRxiv, 2020. | Cancer, Prostate Cancer | Metastatic castration-resistant prostate cancer (mCRPC) | cancer prostate-cancer | metastatic-castration-resistant-prostate-cancer-mcrpc | |||||||
| Lucero-Acuña A., et. al., Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014,1: 5653–5665. | Cancer, Pancreatic Cancer | Overcoming Severe Desmoplasia | cancer pancreatic-cancer | overcoming-severe-desmoplasia | |||||||
| Liu, M., et. al., Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 2015, 195(10): 5055–5065. | Cancer, Lung cancer | M2 to M1 activated macrophage conversion | cancer lung-cancer | m2-to-m1-activated-macrophage-conversion | |||||||
| Ling, Q., et. al., The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 2017, 8(9): 15159–15167. | Cancer, Pancreatic | Associated miRNA expression on PDAC recurrence, Prognostic relevance of primary PDAC location | cancer pancreatic | associated-mirna-expression-on-pdac-recurrence prognostic-relevance-of-primary-pdac-location | |||||||
| Li, Y., et. al., Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of Immunology, 2015, 194(3): 1011-1020. | Cancer, Lymphoma | GVHD prevention and GVT preservation by helminth injection associated induction of Tregs | cancer lymphoma | gvhd-prevention-and-gvt-preservation-by-helminth-injection-associated-induction-of-tregs | |||||||
| Li, S., et. al., Near infrared fluorescent imaging of brain tumor with !R780 dye incorporated phospholipid nanoparticles, Journal of Translational Medicine, 2017, 15:18 | Cancer, Glioblastoma | Image guided oncological surgery, Tumor Detection | cancer glioblastoma | image-guided-oncological-surgery tumor-detection | |||||||
| Lee, S.Y., et. al., Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma. Biomaterials Science, 2019. | Cancer, Lung cancer | Nanoparticle drug delivery optimization | cancer lung-cancer | nanoparticle-drug-delivery-optimization | |||||||
| Lee, S.Y., et. al., An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy. Drug Delivery, 2018, 25(1): 738-749. | Breast Cancer, Cancer | Nanoparticle enzyme-based therapeutic | breast-cancer cancer | nanoparticle-enzyme-based-therapeutic | |||||||
| Lee, S.Y., et. al., Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the bloodstream and improved lung targeting efficiency. Journal of Colloid and Interface Science, 2016, 480: 102–108. | Cancer, Lung cancer | Nanoparticle drug delivery optimization | cancer lung-cancer | nanoparticle-drug-delivery-optimization | |||||||
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| Hardy, S.D. et. al., Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 2017, 8(61): 103302–103314. | Breast Cancer, Cancer | Molecular Biology of Epithelial Mesenchymal transition (EMT) | breast-cancer cancer | molecular-biology-of-epithelial-mesenchymal-transition-emt | |||||||
| Han, N., et. al., Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics, 2017, 14(5): 1538–1547. | Nanoparticle delivery systems | NP targeting of tumor microenvironment (TME) | nanoparticle-delivery-systems | np-targeting-of-tumor-microenvironment-tme | |||||||
| Haber, Z., et. al., Resolving diurnal dynamics of the chloroplastic glutathione redox state in Arabidopsis reveals its photosynthetically-derived oxidation, The Plant Cell, 2021. | Radical Oxygen Species (ROS) | Plant Oxidative Stress | radical-oxygen-species-ros | plant-oxidative-stress | |||||||
| Feng, X., et. al., Responsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals. Chemistry, An Asian Journal, 2018, 10.1002/asia.201800957 | Radical Oxygen Species (ROS) | ROS detection by fluorescence imaging | radical-oxygen-species-ros | ros-detection-by-fluorescence-imaging | |||||||
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| Fan, Q., et. al., Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy, Journal of Controlled Release, 2019, 302: 63-78. | Cancer, Sarcoma | Tumor vascular normalization | cancer sarcoma | tumor-vascular-normalization | |||||||
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| Connolly, R.J., et. al., Development of a catheter-based applicator for immuno-oncology. (Conference Poster). | Cancer, Melanoma | Immunotherapy | BLI | Mouse | Lago | Robert H. Pierce, OncoSec Medical Incorporated, San Diego, CA, USA | na | Melanoma: Immuno-oncology, immunotherapy, electroporation, catheter, intratumoral delivery of cytokine encoding plasmids, IL-12, Probe: luciferase | cancer melanoma | immunotherapy | |
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| Bhutiani, N., et. al., Detection of microspheres in vivo using multispectral optoacoustic tomography. Biotech Histochemistry, 2017, 92(1): 1–6. | Nanoparticles (NPs) | NIRF labeling of NPs | nanoparticles-nps | nirf-labeling-of-nps | |||||||
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