Publications

Cancer

Acute Lymphoblastic Leukemia

Reduce T-cell acute lymphoblastic leukemia (T-ALL) with elevated PIM-kinase expression by using pan PIM-kinase inhibitor

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Various, patient-derived T-ALL cells (acute lyphoblastic leukemia T-cells)


Song, J.H. & Kraft, A.S., 2016. Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 76(s14), pp.4414–4414.

Breast Cancer

Inhibit MDSC in tumor microenvironment with Doxorubicin

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Alizadeh, Darya et al., 2014. Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 74(1), pp.104–118.

Prevent lung metastases by MDSC inhibition

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Borin, T.F. et al., 2017. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS one, 12(6), p.e0178830.

Control 4T1 tumor growth rate and metastasis by regulating DDX6 gene expression

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Hardy, S.D. et al., 2017. Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 8(61), pp.103302–103314.

Breast Cancer with Bone Metastases

Reduce breast cancer bone metastases by blocking c-fms proto-oncogene

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: breast-cancer, bone-homing clone: MDA-MB-231-BO


Jeffery, J.J. et al., 2014. Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 239(4), pp.404–413.

Breast Cancer with Glioblastoma Metastases

Reduce breast cancer brain metastases by blocking PI3K/mTOR Pathway

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived, PIK3CA-mutant cells


Ippen, F.M. et al., 2019. The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(11), pp.3374–3383.

Circulating Tumor Cells

Circulating Tumor Cells expression profile provides resistance to fluid shear stress of vascular environment

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: PC-3 prostate cancer cells


Moose, D.L. et al., 2020. Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 30, pp. 1-11.

Colon Cancer

Track and deliver drug therapeutics to colon tumor cells using DiR labeled NPs

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Modality: FLI  |  Probe(s): DiR  |  Animal Model: Mouse

Cell line: LS174T cells


Han, N. et al., 2017. Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Molecular pharmaceutics, 14(5), pp.1538–1547.

Colorectal Cancer

Improve Photodynamic Therapy of Colorectal Cancer by targeting a vascular Pericyte cell surface

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Modality: FLI  |  Probe(s): IR700 Dye  |  Animal Model: Mouse

Cell line: Patient-derived LS174T cells


Shi, Q. et al., 2017. PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 24(1), pp.1818–1830.

Glioblastoma

Identify cytokines that support BMDC activity in TME

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Modality: FLI  |  Probe(s): GFP  |  Animal Model: Mouse

Cell line: U251 glioma


Achyut, B.R. et al., 2015. Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 369(2), 416–426.

Track BMDCs to tumor microenvironment with GFP transduced cells

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Modality: FLI  |  Probe(s): GFP  |  Animal Model: Mouse

Cell line: U251 glioma


Achyut, B.R. et al., 2016. Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 17(3), pp.280–290.

Control Caspase 3-induced tumor re-angiogenesis after radiation

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: U87 cells cocultured with HUVEC-Fluc, or HMEC-1-Fluc


Feng, X. et al., 2017. Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 385, pp.12–20.

Test hepatocyte GF as a target for treating GBM

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: patient-derived, normal/elevated hepatocyte GF cells


Johnson, J. et al., 2015. Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 13(1), p.306.

IDH-mutant Glioma

Extend survival vs. IDH-mutant gliomas by low-toxicity, intratumoral therapy

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived U87-luc, and MGG152-luc (IDH1-mutant)


Shankar, G.M. et al., 2018. Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 115(36), pp.E8388–E8394.

Intraoperative Tumor Detection Methods

Tumor detection using BLI or FLI technologies

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Modality: BLI/FLI  |  Probe(s): Luciferase/ICG  |  Animal Model: Rat

Cell line: Patient-derived glioma C6 cells


Watson, J.R. 2016 Intraoperative imaging using intravascular contrast agent. Proceedings. 96960L.

Leukemia

GvHD suppressed and GvT preserved by helminths

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Helminth (H. polygyrus); BALB/c mice received total splenic T cells and TCD BM cells from uninfected donor C57BL/6 mice


Li, Y. et al., 2015. Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of immunology (Baltimore, Md. : 1950), 194(3), pp.1011–1020.

GvHD suppressed and GvT preserved by bendamustine

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: CAF1/J mice received T-cell depleted h-BMT or h-BMT/SC from CB6F1 mic


Stokes, J. et al., 2016. Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 174(1), pp.102–116.

Lung Cancer

Reduce TAM immunosupression of Lung (LLC) tumors with β-Glucan

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Modality: Dual FLI  |  Probe(s): XenoLight DiR and VivoTrack 680  |  Animal Model: Mouse

Cell line: LLC cells


Liu, M. et al., 2015. Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 195(10), pp.5055–5065.

Diesel Exhaust Particle (DEP) regulation of Lung Cancer virulence and metastases through Ubiquinilin regulation

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Modality: BLI  |  Probe(s): Luciferase |  Animal Model: Mouse

Cell line: Patient-derived A549 cells; H358 cells, 293 T cells


Yadav, S. et al., 2017. MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 19(4), pp.321–332.

Lung squamous cell carcinoma (LUSC) growth regulation by NSD3 Activity

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Modality: BLI/X-ray  |  Probe(s): Luciferase, akaLuc |  Animal Model: Mouse

Cell line: Patient-derived lung cancer cell lines


Yuan, G. et al., 2021. Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, Feb;590(7846):504-508.

Melanoma

Provide immunotherapy by intratumoral plasmid gene delivery

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: intratumoral plasmid gene delivery


Barrami, A.J. et al., 2017. A novel approach for endoscopic gene transfer

Use BLI to track catheter intratumoral pDNA delivery in immuno-oncology model

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: intratumoral plasmid gene delivery


Connolly, R.J. et al. Development of a catheter-based applicator for immuno-oncology

Nanoparticle: Drug Delivery to Tumor

Optimize nanoparticle tumor uptake

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S2-VP10 cells


England, C.G. et al., 2015. Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging. PloS one, 10(6), p.e0129172.

PLGA NPs delivery to lung vasculature optimized by Chitosan Modified PLGA NPs

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Modality: FLI  |  Probe(s): Cy5.5  |  Animal Model: Mouse

Cell line: N/A


Lee, S. Y. et al., 2016. Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency. Journal of Colloid And Interface Science, 480, pp.102–108.

Glycol chitosan NPs serve as effective cancer therapeutic drug vehicles for both Doxirubicine and Bcl-2 siRNA

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Modality: FLI  |  Probe(s): Cy5.5  |  Animal Model: Mouse

Cell line: PC-3 cells


Yoon, H. Y. et al., 2014. Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 4(1), p.6878.

Nanoparticle: Optimized Tumor Detection

Pancreatic tumor detection improved by use of gold nanorods

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Modality: FLI  |  Probe(s): IR-780 dye (see supplemental figures)  |  Animal Model: Mouse

Cell line: S2-VP10 cells


Zeiderman, M.R. et al., 2016. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2(7), pp.1108–1120.

Non-Hodgkin's Lymphoma

Enhanced specificity and lower toxicity of NHL therapeutic by delivery with dual Ab Nanoparticle construct

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Modality: FLI  |  Probe(s): Cy5  |  Animal Model: Mouse

Cell line: Jurkat, Ramos, Namalwa, Daudi, and Raji


Au, KM el al., 2020. Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin’s lymphoma. Science Advances, 6: eaaz9798, pp. 1-12.

Pancreatic Adenocarcinoma

Improve targeting of pancreatic tumors by Syndecan-1-liposome conjugates

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Modality: BLI, FLI  |  Probe(s): Luciferase, 750  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10 cells


Yin, W et al., 2016.Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences Senior Honors Theses. Paper 126.

Pancreatic Cancer

Evaluate X-ray effect on tumor growth

Poster


Modality: BLI/X-Ray  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S2-VP10 cells


England, C.G et al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor

Detect pancreatic tumors using BLI/FLI

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Modality: BLI, FLI  |  Probe(s): Luciferase, CF-750  |  Animal Model: Mouse

Cell line: S2VP10 cells


Hudson, S.V. et al., 2014. Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer research, 74(21), pp.6271–6279.

Target Pancreatic cancer In vivo with NIRF probes

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Modality: BLI, FLI  |  Probe(s): luciferase, NIR dye  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10 and S2VP10L cells


Kimbrough, C.W. et al., 2015. Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 193(1), pp.246–254.

Better predict In vivo drug efficacies with new In vitro cell culture set-up

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10L and MiaPaCa-2 cells


Lee, J. et al., 2013. Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer. PLoS Computational Biology, 9(9), p.e1003231.

Use nanoparticle-drug conjugate to improve drug delivery and efficacy

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived MiaPaCa cells


Lucero-Acuña A et al., 2014. Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014(Issue 1), pp.5653–5665.

Suppress growth of Pancreatic Cancer mets by Dnase treatment

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived MiaPaCa-2, BxPc3, and Panc-1cells


Wen, F. et al., 2013. Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 73(14), pp.4256–4266.

Pancreatic Ductal Adenocarcinoma

Invasive phenotype of PDA is moderated by a recovery or enhanced expression of extracellular superoxide dismutase (EcSOD) by PDA cells

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: BxPC3 cells transfected with firefly luciferase gene, Luc2


O’Leary, B.R. et al., 2015. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma

Detection of PDA circulating tumor cells, in vivo and ex vivo

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Modality: BLI, FLI  |  Probe(s): Luciferase, GFP  |  Animal Model: Mouse

Cell line: MIA PaCa-2 cells, expressing luciferase and GFP


Alexander, M.S. et al., 2018. A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells

High dose, IV ascorbate (Vit C) for In vivo PDAC model significantly reduces ascites formation, tumor burden over time, circulating tumor cells and hepatic metastases

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Human PDAC cell line MIA PaCa-2 expressing luciferase and GFP


O’Leary, B.R. et al., 2020. Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 10:17649

Target PDAC In vivo with NIRF probes

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Modality: BLI, FLI  |  Probe(s): Luciferase, 750 NIR fluorescent dye  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10L and S2013Q cells


Kimbrough, Charles W et al., 2015. Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), pp.4576–4585.

Predict pancreatic tumor metastic virulence by location of primary tumor

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Panc-1/Luc cells


Ling, Q. et al., 2017. The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 8(9), pp.15159–15167.

Prostate Cancer

Prevent prostate cancer metastases by blocking PMSA

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Modality: BLI, FLI  |  Probe(s): Luciferase, IRDye 800 CW  |  Animal Model: Mouse

Cell line: PC3 (PSMA++) cells


Dassie et al., 2014. Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 22(11), pp.1910–1922.

Inhibit prostate cancer cell invasion and migration by synergy of Notch1 inhibition and antiandrogens

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived 22RV1-Luc or Delta-Notch1-Luc cell lines


Rice, M.A. et al., 2019. Loss of Notch1 Activity Inhibits Prostate Cancer Growth and Metastasis and Sensitizes Prostate Cancer Cells to Antiandrogen Therapies. Molecular cancer therapeutics, 18(7), pp.1230–1242.

Suppress prostate cancer mets by a α3β1 intigrin-Abl kinase-Hippo suppressor pathway

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Modality: BLI/FLI  |  Probe(s): Luciferase, GFP  |  Animal Model: Mouse

Cell line: Patient-derived PC3 and DU145 cells


Varzavand, A. et al., 2016. α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer research, 76(22), pp.6577–6587.

BLI monitoring of Pten and Trp53 double, homozygous KOs, with aggressive but not metastatic prostate cancer

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Modality: BLI  |  Probe(s): Luciferase |  Animal Model: Mouse

Cell line: Adenovirus with CRE recombinase into Albino C57BL/6 mice w/ floxed Pten and Trp53 and ROSA26 LSL-Luc


Yong, C. et al., 2020. Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 15(9): e0232807

Sarcoma

Induce In vivo tumor formation

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Viral-mediated Trp53/Pten knock out


Buchakjian, M.R. et al., 2017. A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS ONE, 12(8), p.e0183469.

T-Cell Acute Lymphoblastic Leukemia

Optimize ETP-ALL therapy with pan-PIM kinase and/or ponatinib

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived ETP-ALL cell lines


Padi, S.K.R. et al., 2017. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 77(s13), pp.5820–5820.

Tongue Carcinoma

Induce In vivo tumor formation

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Viral-mediated Trp53/Pten knock out


Buchakjian, M.R. et al., Trp53 PTEN Inducible knockout mice and viral delivery techniques

Immunology

Immune Response

Moderate macrofage-associated inflammation, apoptosis, and bacteriocidal activitiy vs. S. aureus by Vit E UHMWPE particles

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S. aureus cells


Chen, W. et al., 2017. Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus. Biomaterials, 143, pp.46–56.

Bone and Joints

Nanoparticle: Drug-Eluting Bone Joint Implant

Compare Antibacterial efficacies of new UHMWPE and gold-standard Bone Cement Joint Implants in rabbit model

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Rabbit

Cell line: S. aureus cells


Suhardi et al., 2017. A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. 2017. “A Fully Functional Drug-Eluting Joint Implant.” Nature biomedical engineering 1 (1): 0080. doi:10.1038/s41551–017-0080. http://dx.doi.org/10.1038/s41551–017-0080.

Healing of a Femoral Fracture

Femur healing rate enhanced by f-BCSP cells

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Modality: X-Ray  |  Probe(s): N/A  |  Animal Model: Mouse


Marecic, O et al., 2015. Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 112(32), pp.9920–9925.

Technical

Bioluminescent Imaging

BLI radiance threshold sensitivities of detection systems

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 22Rv1.lucPN2, viral-mediated Trp53/Pten knock out


Henry, M.D. et al., Comparison of High Sensitivity BLI Imaging Systems for Ultra-weak Signal Applications

Cerenkov Luminescent Imaging

Cerenkov Luminescent Imaging with the Ami HT

Poster


Modality: CLI  |  Probe(s): Cerenkov  |  Animal Model: Mouse

Cell line: N/A


Dykstra, M. et al., In vitro and in vivo studies of cerenkov luminescence imaging

X-Ray Imaging

Ultra high dose irradiation using a Clinical Linear Accelerator

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Modality: N/A  |  Probe(s): X-Ray  |  Animal Model: Mouse

Cell line: N/A


Schüler, E. et al., 2017. Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 97(1), pp.195–203.

Virology

Bioluminescent Imaging

BLI radiance threshold sensitivities of detection systems

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 22Rv1.lucPN2, viral-mediated Trp53/Pten knock out


Henry, M.D. et al., Comparison of High Sensitivity BLI Imaging Systems for Ultra-weak Signal Applications

Sarcoma

Induce In vivo tumor formation

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Viral-mediated Trp53/Pten knock out


Buchakjian, M.R. et al., 2017. A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS ONE, 12(8), p.e0183469.

Plant Pathogens

Bacterial Cross-contamination during Crop Harvesting

Reduction of E.coli 0157:H7 transfer between lettuce plants by redesign of coring tool, and Cross-contamination of Salmonella as a function of Rinsing Solution

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Modality: BLI  |  Probe(s): Luciferase  |  Model: Coring machine, Iceberg Lettuce

Cell line: Escherichia coli 0157:H7, Salmonella Newport SN78, transformed with pAKlux 1 pasmid


Kumar, G.D. et al., 2019. Modified Coring Tool Designs Reduce Iceberg Lettuce Cross-Contamination.

Plant Stress

Fluorescent Imaging

FLI detection of whole-plant redox stress

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Modality: FLI  |  Probe(s): Reduction-oxidation-sensitive GFP2 (reGFP2)  |  Model: Potato Plant (cv. Desiree)


Hipsch, M. et al., 2020. Sensing Stress responses in potato with whole-plant redox imaging. Published by BioRxiv, with permission of author/funder, prior to peer reivew.

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