Publications
Acute Lymphoblastic Leukemia
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Various, patient-derived T-ALL cells (acute lyphoblastic leukemia T-cells)
Song, J.H. & Kraft, A.S., 2016. Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 76(s14), pp.4414–4414.
Breast Cancer
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: 4TI cells
Alizadeh, Darya et al., 2014. Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 74(1), pp.104–118.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: 4TI cells
Borin, T.F. et al., 2017. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS one, 12(6), p.e0178830.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: 4TI cells
Hardy, S.D. et al., 2017. Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 8(61), pp.103302–103314.
Breast Cancer with Bone Metastases
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: breast-cancer, bone-homing clone: MDA-MB-231-BO
Jeffery, J.J. et al., 2014. Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 239(4), pp.404–413.
Breast Cancer with Glioblastoma Metastases
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Patient-derived, PIK3CA-mutant cells
Ippen, F.M. et al., 2019. The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(11), pp.3374–3383.
Circulating Tumor Cells
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: PC-3 prostate cancer cells
Moose, D.L. et al., 2020. Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 30, pp. 1-11.
Colon Cancer
Modality: FLI | Probe(s): DiR | Animal Model: Mouse
Cell line: LS174T cells
Han, N. et al., 2017. Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Molecular pharmaceutics, 14(5), pp.1538–1547.
Colorectal Cancer
Modality: FLI | Probe(s): IR700 Dye | Animal Model: Mouse
Cell line: Patient-derived LS174T cells
Shi, Q. et al., 2017. PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 24(1), pp.1818–1830.
Glioblastoma
Modality: FLI | Probe(s): GFP | Animal Model: Mouse
Cell line: U251 glioma
Achyut, B.R. et al., 2015. Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 369(2), 416–426.
Modality: FLI | Probe(s): GFP | Animal Model: Mouse
Cell line: U251 glioma
Achyut, B.R. et al., 2016. Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 17(3), pp.280–290.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: U87 cells cocultured with HUVEC-Fluc, or HMEC-1-Fluc
Feng, X. et al., 2017. Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 385, pp.12–20.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: patient-derived, normal/elevated hepatocyte GF cells
Johnson, J. et al., 2015. Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 13(1), p.306.
IDH-mutant Glioma
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Patient-derived U87-luc, and MGG152-luc (IDH1-mutant)
Shankar, G.M. et al., 2018. Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 115(36), pp.E8388–E8394.
Intraoperative Tumor Detection Methods
Modality: BLI/FLI | Probe(s): Luciferase/ICG | Animal Model: Rat
Cell line: Patient-derived glioma C6 cells
Watson, J.R. 2016 Intraoperative imaging using intravascular contrast agent. Proceedings. 96960L.
Leukemia
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Helminth (H. polygyrus); BALB/c mice received total splenic T cells and TCD BM cells from uninfected donor C57BL/6 mice
Li, Y. et al., 2015. Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of immunology (Baltimore, Md. : 1950), 194(3), pp.1011–1020.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: CAF1/J mice received T-cell depleted h-BMT or h-BMT/SC from CB6F1 mic
Stokes, J. et al., 2016. Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 174(1), pp.102–116.
Lung Cancer
Modality: Dual FLI | Probe(s): XenoLight DiR and VivoTrack 680 | Animal Model: Mouse
Cell line: LLC cells
Liu, M. et al., 2015. Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 195(10), pp.5055–5065.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Patient-derived A549 cells; H358 cells, 293 T cells
Yadav, S. et al., 2017. MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 19(4), pp.321–332.
Modality: BLI/X-ray | Probe(s): Luciferase, akaLuc | Animal Model: Mouse
Cell line: Patient-derived lung cancer cell lines
Yuan, G. et al., 2021. Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, Feb;590(7846):504-508.
Melanoma
Poster
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: intratumoral plasmid gene delivery
Barrami, A.J. et al., 2017. A novel approach for endoscopic gene transfer
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: intratumoral plasmid gene delivery
Connolly, R.J. et al. Development of a catheter-based applicator for immuno-oncology
Nanoparticle: Drug Delivery to Tumor
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: S2-VP10 cells
England, C.G. et al., 2015. Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging. PloS one, 10(6), p.e0129172.
Modality: FLI | Probe(s): Cy5.5 | Animal Model: Mouse
Cell line: N/A
Lee, S. Y. et al., 2016. Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency. Journal of Colloid And Interface Science, 480, pp.102–108.
Modality: FLI | Probe(s): Cy5.5 | Animal Model: Mouse
Cell line: PC-3 cells
Yoon, H. Y. et al., 2014. Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 4(1), p.6878.
Nanoparticle: Optimized Tumor Detection
Modality: FLI | Probe(s): IR-780 dye (see supplemental figures) | Animal Model: Mouse
Cell line: S2-VP10 cells
Zeiderman, M.R. et al., 2016. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2(7), pp.1108–1120.
Non-Hodgkin's Lymphoma
Modality: FLI | Probe(s): Cy5 | Animal Model: Mouse
Cell line: Jurkat, Ramos, Namalwa, Daudi, and Raji
Au, KM el al., 2020. Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin's lymphoma. Science Advances, 6: eaaz9798, pp. 1-12.
Pancreatic Adenocarcinoma
Modality: BLI, FLI | Probe(s): Luciferase, 750 | Animal Model: Mouse
Cell line: Patient-derived S2VP10 cells
Yin, W et al., 2016.Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences Senior Honors Theses. Paper 126.
Pancreatic Cancer
Modality: BLI/X-Ray | Probe(s): Luciferase | Animal Model: Mouse
Cell line: S2-VP10 cells
England, C.G et al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor
Modality: BLI, FLI | Probe(s): Luciferase, CF-750 | Animal Model: Mouse
Cell line: S2VP10 cells
Hudson, S.V. et al., 2014. Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer research, 74(21), pp.6271–6279.
Modality: BLI, FLI | Probe(s): luciferase, NIR dye | Animal Model: Mouse
Cell line: Patient-derived S2VP10 and S2VP10L cells
Kimbrough, C.W. et al., 2015. Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 193(1), pp.246–254.
Modality: BLI | Probe(s): luciferase | Animal Model: Mouse
Cell line: Patient-derived S2VP10L and MiaPaCa-2 cells
Lee, J. et al., 2013. Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer. PLoS Computational Biology, 9(9), p.e1003231.
Modality: BLI | Probe(s): luciferase | Animal Model: Mouse
Cell line: Patient-derived MiaPaCa cells
Lucero-Acuña A et al., 2014. Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014(Issue 1), pp.5653–5665.
Modality: BLI | Probe(s): luciferase | Animal Model: Mouse
Cell line: Patient-derived MiaPaCa-2, BxPc3, and Panc-1cells
Wen, F. et al., 2013. Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 73(14), pp.4256–4266.
Pancreatic Ductal Adenocarcinoma
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: BxPC3 cells transfected with firefly luciferase gene, Luc2
O'Leary, B.R. et al., 2015. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma
Modality: BLI, FLI | Probe(s): Luciferase, GFP | Animal Model: Mouse
Cell line: MIA PaCa-2 cells, expressing luciferase and GFP
Alexander, M.S. et al., 2018. A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Human PDAC cell line MIA PaCa-2 expressing luciferase and GFP
O'Leary, B.R. et al., 2020. Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 10:17649
Modality: BLI, FLI | Probe(s): Luciferase, 750 NIR fluorescent dye | Animal Model: Mouse
Cell line: Patient-derived S2VP10L and S2013Q cells
Kimbrough, Charles W et al., 2015. Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), pp.4576–4585.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Panc-1/Luc cells
Ling, Q. et al., 2017. The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 8(9), pp.15159–15167.
Prostate Cancer
Modality: BLI, FLI | Probe(s): Luciferase, IRDye 800 CW | Animal Model: Mouse
Cell line: PC3 (PSMA++) cells
Dassie et al., 2014. Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 22(11), pp.1910–1922.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Patient-derived 22RV1-Luc or Delta-Notch1-Luc cell lines
Rice, M.A. et al., 2019. Loss of Notch1 Activity Inhibits Prostate Cancer Growth and Metastasis and Sensitizes Prostate Cancer Cells to Antiandrogen Therapies. Molecular cancer therapeutics, 18(7), pp.1230–1242.
Modality: BLI/FLI | Probe(s): Luciferase, GFP | Animal Model: Mouse
Cell line: Patient-derived PC3 and DU145 cells
Varzavand, A. et al., 2016. α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer research, 76(22), pp.6577–6587.
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Adenovirus with CRE recombinase into Albino C57BL/6 mice w/ floxed Pten and Trp53 and ROSA26 LSL-Luc
Yong, C. et al., 2020. Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 15(9): e0232807
Sarcoma
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Viral-mediated Trp53/Pten knock out
Buchakjian, M.R. et al., 2017. A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS ONE, 12(8), p.e0183469.
T-Cell Acute Lymphoblastic Leukemia
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Patient-derived ETP-ALL cell lines
Padi, S.K.R. et al., 2017. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 77(s13), pp.5820–5820.
Tongue Carcinoma
Poster
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Viral-mediated Trp53/Pten knock out
Buchakjian, M.R. et al., Trp53 PTEN Inducible knockout mice and viral delivery techniques
Immune Response
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: S. aureus cells
Chen, W. et al., 2017. Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus. Biomaterials, 143, pp.46–56.
Nanoparticle: Drug-Eluting Bone Joint Implant
Modality: BLI | Probe(s): Luciferase | Animal Model: Rabbit
Cell line: S. aureus cells
Suhardi et al., 2017. A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. 2017. “A Fully Functional Drug-Eluting Joint Implant.” Nature biomedical engineering 1 (1): 0080. doi:10.1038/s41551–017-0080. http://dx.doi.org/10.1038/s41551–017-0080.
Healing of a Femoral Fracture
Modality: X-Ray | Probe(s): N/A | Animal Model: Mouse
Marecic, O et al., 2015. Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 112(32), pp.9920–9925.
Bioluminescent Imaging
Poster
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: 22Rv1.lucPN2, viral-mediated Trp53/Pten knock out
Henry, M.D. et al., Comparison of High Sensitivity BLI Imaging Systems for Ultra-weak Signal Applications
Cerenkov Luminescent Imaging
Poster
Modality: CLI | Probe(s): Cerenkov | Animal Model: Mouse
Cell line: N/A
Dykstra, M. et al., In vitro and in vivo studies of cerenkov luminescence imaging
X-Ray Imaging
Modality: N/A | Probe(s): X-Ray | Animal Model: Mouse
Cell line: N/A
Schüler, E. et al., 2017. Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 97(1), pp.195–203.
Bioluminescent Imaging
Poster
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: 22Rv1.lucPN2, viral-mediated Trp53/Pten knock out
Henry, M.D. et al., Comparison of High Sensitivity BLI Imaging Systems for Ultra-weak Signal Applications
Sarcoma
Modality: BLI | Probe(s): Luciferase | Animal Model: Mouse
Cell line: Viral-mediated Trp53/Pten knock out
Buchakjian, M.R. et al., 2017. A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS ONE, 12(8), p.e0183469.
Bacterial Cross-contamination during Crop Harvesting
Modality: BLI | Probe(s): Luciferase | Model: Coring machine, Iceberg Lettuce
Cell line: Escherichia coli 0157:H7, Salmonella Newport SN78, transformed with pAKlux 1 pasmid
Kumar, G.D. et al., 2019. Modified Coring Tool Designs Reduce Iceberg Lettuce Cross-Contamination.
Fluorescent Imaging
Modality: FLI | Probe(s): Reduction-oxidation-sensitive GFP2 (reGFP2) | Model: Potato Plant (cv. Desiree)
Hipsch, M. et al., 2020. Sensing Stress responses in potato with whole-plant redox imaging. Published by BioRxiv, with permission of author/funder, prior to peer reivew.
