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Madhurima, G., Sanjeez, D. PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis. 2021. Vol 118 No. 40.TumorigebesisUbiquitylationBLIMouseLago XSanjeev Dasa, Molecular Oncology Laboratory, National Institute of Immunology, New Delhi 110067, India2021Delineated PRAMEF2 regulation under low-nutrient conditions. Also showed that it promotes proteasomal degradation of LATS1 kinase of the Hippo/YAP pathway. LATS1 downregulation triggers nuclear accumulation of the transcriptional coactivator YAP, which induces the expression of proliferative and metastatic genes. Thus, PRAMEF2 promotes malignant phenotype in a YAP-dependent manner. Taken together, the findings reveal a pivotal role for PRAMEF2 in determining YAP oncogenic signaling, which has key implications for tumorigenesis.tumorigebesisubiquitylation
Hu, X. et al. Gypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaquesImmunologyGenetic engineering of allogenic cell therapeuticsBLIRhesus MacaquesLagoSonja Schrepfer, Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA 94080, USA2023Engineered rhesus macaque human hypoimmune pluripotent (HIP) cells and transplanted them intramuscularly into four allogeneic rhesus macaques. The HIP cells survived unrestricted for 16 weeks in fully immunocompetent allogeneic recipients and diferentiated into several lineages, whereas allogeneic wild-type cells were vigorously rejectedimmunologygenetic-engineering-of-allogenic-cell-therapeutics
Zhang, Q. et al. Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer. Pharmaceutics. 2022. 14, 510.Cancer, Lung cancerNanomicelle-Microsphere Composite as a Drug CarrierFLIMouseAmi HTRongfeng Hu, Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Key Laboratory of Xin’an Medicine, the Ministry of Education, Anhui Province Key Laboratory of Chinese Medicinal Formula, Plant Active Peptide Function Food Innovative Manufacturing Industry Innovation Team, Anhui University of Chinese Medicine, Hefei 230038, China2022Developed a nanomicelle-microsphere composite, in which doxorubicin (DOX) was loaded with spermine (Spm) modified poly (ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) micelles, and then the nanomicelles were noncovalently adsorbed on the surface of poly (lactic-co-glycolic acid) (PLGA) microspheres. An orthotopic lung cancer implantation model based on C57BL/6 mice was established, and in vivo biodistribution studies confirmed that the complex improved the distribution of DOX in the lungs and displayed notable tumor targeting. Probe: DOX-loaded micelles.cancer lung-cancernanomicelle-microsphere-composite-as-a-drug-carrier
Jussi Taipale, 1 Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDiabetesType 1 DiabetesBLIMouseAmi HTSonja Schrepfer, Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA 94080, USA2023Editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47 overexpressing phenotype and their reaggregation into human HIP pseudoislets (p-islets). Human HIP p-islets were shown to survive, engraft, and ameliorate diabetes in immunocompetent, allogeneic, diabetic humanized mice.diabetestype-1-diabetes
Biswajyoti, S. et al. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021, 40:5533–5547.CancerCancer GeneticsFLIMouseLagoJussi Taipale, 1 Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland2021Combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. Reprogramming fibroblasts to a liver progenitor fate, induced hepatocytes (iHeps), makes them sensitive to transformation by the same oncogenes. Tumorigenesis is triggered by a combination of three elements: the set of driver mutations, the cellular lineage, and the state of differentiation of the cells along the lineage. Probe: mCherry.cancercancer-genetics
Amano, T. et al. Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity. iScience. 2023, 26,106335.Pathogenic CoronavirusesAcute respiratory syndrome coronavirus 2 (SARS-CoV-2) - SARS-CoV - Middle East respiratory syndrome coronavirus (MERS-CoV)"BLIMouseAmi HTMinoru S.H. Ko, Elixirgen Therapeutics, Inc., Baltimore, MD, USA2022Developed an mRNA vaccine platform for skin delivery without nanoparticles. developed an srRNA that functions optimally at around 33C (skin temperature) and is inactivated at or above 37C (core body temperature) as a safety switch. This temperature-controllable srRNA (c-srRNA), when tested as an intradermal vaccine against SARS-CoV-2, functions when injected naked without lipid nanoparticles.pathogenic-coronavirusesacute-respiratory-syndrome-coronavirus-2-sars-cov-2-sars-cov-middle-east-respiratory-syndrome-coronavirus-mers-cov
Karsten, L. et al. Bivalent EGFR-Targeting DARPin-MMAE Conjugates. International Journal of Molecular Sciences. 2022, 23: 2468.Cancer, Squamous Cell Carcinoma and GliomaAntibody-drug conjugatesFLIMouseLagoKristian Muller, Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, 33615 Bielefeld, Germany2022Constructed protein-drug conjugates based on the anti-Epidermal growth factor receptor (EGFR). Designed Ankyrin Repeat Protein (DARPin) E01, and compared the bivalent DARPin dimer (DD1) and a DARPin-Fc (DFc) to the monomeric DARPin (DM) and the antibody derived scFv425-Fc (scFvFc) in cell culture and a mouse model. Probe: Alexa Fluor 647.cancer squamous-cell-carcinoma-and-gliomaantibody-drug-conjugates
Park, S. et al. Bioluminescence Imaging of Matrix Metalloproteinases-2 and -9 Activities in Ethanol-injured Cornea of Mice. in vivo. (2021) 35: 1521-1528.Ethanol-induced damage in the cornea of miceRole of matrix metalloproteinases (MMP)-2 and MMP-9 activationBLIMouseAmi HTXKyung-Jong Won, Department of Physiology, Konkuk University School of Medicine, Seoul, Republic of Korea2021BLI can be applied in vivo in mice with corneal injury to examine the activity of MMPs and clarify the efficacy of eye drops.ethanol-induced-damage-in-the-cornea-of-micerole-of-matrix-metalloproteinases-mmp-2-and-mmp-9-activation
Andradas, C. et al. Assessment of Cannabidiol and Δ9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma. Cancers (Basel). 2021 Jan 18;13(2):330.Cancer, MedullablastomaAssessment of Cannabidiol and ∆9-TetrahydrocannabiolBLIMouseLago XClara Andradas, Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA 6009, Australia.2021Cannabinoids had cytotoxic activity against medulloblastoma and ependymoma cells in vitro, functioning in part through the inhibition of cell cycle progression and the induction of autophagy. Despite these effects in vitro, when tested in orthotopic mouse models of medulloblastoma or ependymoma, no impact on animal survival was observed.cancer medullablastomaassessment-of-cannabidiol-and-%e2%88%869-tetrahydrocannabiol
Lopez-Pier, M., et al. An adaptable and non-invasive method for tracking Bifidobacterium animalis subspecies lactis 420 in the mouse gut. J Microbial Methods, 2021, 189: 106302Gut MicrobiotaTracking bacteria in the gutFLIMouseLago XJohn Konhilas, Department of Physiology, University of Arizona, Tucson, AZ2021Labeling of microbial species with an externally detectable marker allows detection as to their specific geographic residence/location during transit through the gut. Incubated B420 with common, FDA-approved contrast agents, ISOVUE-300 or indocyanine green (ICG), and visualized by x-ray fluoroscopy (ISOVUE-300) or fluorescence (ICG) along the GI tract at different timepoints. Validated and quantified B420 using quantitative PCR at different regions of the GI tract. ICG was a more effective labeling agent over ISOVUE-300. Probe: Indocyanine green (ICG).gut-microbiotatracking-bacteria-in-the-gut
Choi, J., et al. A unique subset of glycolytic tumor propagating cells drives squamous cell carcinoma. Nat. Metab. 2021. 3(2): 182–195.Cancer, Head and Neck Squamous Cell CarcinomaTumor progressionBLIMouseAmi HTXRaul Mostoslavsky, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA2021Defined a subset of Tumor Propagating Cells (TPCs) as exhibiting increased glutathione (GSH) and provided strong in vivo data for the importance of increased glycolysis in generating glutathione and defending against oxidative stress. Discovered a unique “metabolic heterogeneity” within TPCs, indicating that only a defined (previously unknown) subpopulation of CD34+ TPCs acquires metabolic adaptations that could drive tumorigenesiscancer head-and-neck-squamous-cell-carcinomatumor-progression
Abramson, A., et al. A flexible electronic strain sensor for the real-time monitoring of tumor regression. Science Advances, 2022, 8, eabn6650Cancer, Lung cancerTumor size monitoringBLIMouseLago XZhenan Bao, 1 Department of Chemical Engineering, Stanford University, Stanford, CA2022Commercially scalable wearable electronic strain sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring the micrometer-scale progression or regression of subcutaneously implanted tumors at the minute time scale. Regression measurements were validated through histology, and caliper and bioluminescence measurementscancer lung-cancertumor-size-monitoring
Yang, F., et al. A biomineral-inspired approach of synthesizing colloidal persistent phosphors as a multicolor, intravital light source. Science Advances, 2022, 8, eabo6743OpticsNanophosphor DevelopmentFLIMouseLago XGuosong Hong, Department of Materials Science and Engineering, Stanford University, Stanford, CA2022Bioinspired demineralization (BID) strategy to synthesize stable colloidal solutions of solid-state phosphors in the range of 470 to 650 nm and diameters down to 20 nm. The exceptional brightness of BID-produced colloids enables their utility as multicolor luminescent tags in vivo with favorable biocompatibility. Because of their stable dispersion in water, BID-produced nanophosphors can be delivered systemically, acting as an intravascular colloidal light source to internally excite genetically encoded fluorescent reporters within the mouse brain. Probe: nanophosphor colloidopticsnanophosphor-development
Zhong, Y., et. al., Co-administration of of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment. International Journal of Nanomedicine, 2019, 14: 8543–8560.Cancer, Colorectal CancerNanoparticle (NP) therapeutic delivery for colorectal cancer:cancer colorectal-cancernanoparticle-np-therapeutic-delivery-for-colorectal-cancer
Zhong, Q., et. al., Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters, Biomaterials, June 2020, 206: 73-86.Therapeutic Drug DeliveryUltrasound-activated drug-loaded nanoemulsionstherapeutic-drug-deliveryultrasound-activated-drug-loaded-nanoemulsions
Zeiderman, M.R., et. al., Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2016, 2(7), 1108–1120.Cancer, Pancreatic CancerPancreatic tumor detection and treatment with novel theranostic particlescancer pancreatic-cancerpancreatic-tumor-detection-and-treatment-with-novel-theranostic-particles
Yuan, G., et. al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, 2021, 590(7846), 504-508.Cancer, Lung cancerLung squamous cell carcinoma (LUSC) tumorigenesiscancer lung-cancerlung-squamous-cell-carcinoma-lusc-tumorigenesis
Yoon, H.Y., et. al., Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 2014, 4(1), 6878.Cancer, Prostate CancerGlycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehiclescancer prostate-cancerglycol-chitosan-nanoparticles-cnps-as-specialized-cancer-therapeutic-vehicles
Yong, C., et. al., Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 2020, 15(9).Cancer, Prostate CancerCastration resistant invasive prostate cancercancer prostate-cancercastration-resistant-invasive-prostate-cancer
Yin, W., et. al., Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences, Senior Honors Theses, 2016, Paper 126.Cancer, Pancreatic CancerDirected-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinomacancer pancreatic-cancerdirected-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma
Yin, W., et. al., Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography, Journal of Nanobiotechnology, 2015, 13:90.Cancer, Pancreatic CancerDirected-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinomacancer pancreatic-cancerdirected-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma
Yang, H., et. al., Endogenous IgG-based affinity-controlled release of TRAIL exerts superior antitumor effects, Theranostics, 2018, 8(9): 2459-2476.Cancer, Colorectal CancerTRAIL in vivo pharmacokinetics optimized for superior antitumor efficacycancer colorectal-cancertrail-in-vivo-pharmacokinetics-optimized-for-superior-antitumor-efficacy
Yadav, S., et. al., MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 2017, Vol. 19, No. 4, pp. 321-332Cancer, Lung cancermiRNA-mediated loss of Ubiquilin protein expressioncancer lung-cancermirna-mediated-loss-of-ubiquilin-protein-expression
Wu, B., et. al., Oligo(ethylene glycol)-functionalized squaraine fluorophore as a near-infrared-fluorescent probe for the in vivo detection of diagnostic enzymes. Analytical Chemistry, 2018, 90:9359-9365.Cancer, Liver CancerIn vivo detection of tumor-associated diagnostic enzymescancer liver-cancerin-vivo-detection-of-tumor-associated-diagnostic-enzymes
Wen, F., et. al., Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 2013, 73(14), pp.4256–4266.Cancer, Pancreatic CancerExtracellular DNA promotes tumor-associated inflammation; cell invasion and aggressive metastasiscancer pancreatic-cancerextracellular-dna-promotes-tumor-associated-inflammation-cell-invasion-and-aggressive-metastasis
Watson, J.R.,, Intraoperative imaging using intravascular contrast agent. Society of Photo-Optical Instrumentation Engineers, Conference Proceedings, 2016, Vol.9696.Cancer, GlioblastomaIntraoperative tumor detectioncancer glioblastomaintraoperative-tumor-detection
Varzavand, A., et. al., α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer Research, 2016, 76(22), 6577–6587.Cancer, Prostate CancerProstate cancer metastasis regulationcancer prostate-cancerprostate-cancer-metastasis-regulation
Tao, Z., et. al., Targeted delivery to tumor-associated pericytes via an affibody with high affinity for PDGFRβ enhances the in vivo antitumor effects of human TRAIL. Theranostics, 2017, 7(8): 2261-2276.Cancer, Colon CancerTumor-targeted hTRAIL therapycancer colon-cancertumor-targeted-htrail-therapy
Tang, A.C., et. al. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. Cell Death and Disease, 2018, 9:162.Cancer, haematological malignanciesCombination therapy of proteasome inhibitors and Toll-like receptor agonistscancer haematological-malignanciescombination-therapy-of-proteasome-inhibitors-and-toll-like-receptor-agonists
Sukumar, U.K., et. al., SP94-targeted triblock copolymer nanoparticle delivers thymidine kinase-p53-nitroreductase triple therapeutic gene and restores anticancer function against hepatocellular carcinoma in vivo. ACS Applied Material Interfaces, March 2020, 12(10): 11307-11319.Cancer, Hepatocellular CarcinomaGene-directed enzyme–prodrug therapy (GDEPT)cancer hepatocellular-carcinomagene-directed-enzyme-prodrug-therapy-gdept
Sukumar, U.K., et. al., Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to Temozolomide. Biomaterials, October 2019, 218.Cancer, GlioblastomaTheranostic; intranasal and systemic combinatorial therapy of GBMcancer glioblastomatheranostic-intranasal-and-systemic-combinatorial-therapy-of-gbm
Suhardi, V.J., et. al., A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. Nat Biomed Eng. 2017, 1.Revision of Infected Prosthetic JointsAntibiotic drug delivery and mechanical strength of prosthetic joint implant materialrevision-of-infected-prosthetic-jointsantibiotic-drug-delivery-and-mechanical-strength-of-prosthetic-joint-implant-material
Su, Y., et. al., Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals, Nature Methods, 2020, 17, 852–860.Bioluminescent ImagingDual Bioluminescence Imagingbioluminescent-imagingdual-bioluminescence-imaging
Stokes, J., et. al., Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 2016, 174(1), 102–116.Cancer, LymphomaGVHD prevention and GVL preservationcancer lymphomagvhd-prevention-and-gvl-preservation
Song, J.H. & Kraft, A.S., Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 2016, 76(s14), 4414–4414.Cancer, LymphomasPim Kinase substrates and associated regulatory pathwayscancer lymphomaspim-kinase-substrates-and-associated-regulatory-pathways
Shin, J.M., et. al., A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy. Biomaterials Research, 2018, 22:21.Cancer, Cervical CancerImmunotherapy by polymeric antigen carriercancer cervical-cancerimmunotherapy-by-polymeric-antigen-carrier
Shi, Q., et. al., PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 2017, 24(1), pp.1818–1830.Cancer, Colorectal CancerPhotodynamic therapycancer colorectal-cancerphotodynamic-therapy
Shankar, G.M., et. al., Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(36), E8388–E8394.Cancer, GlioblastomaGenotype-targeted therapycancer glioblastomagenotype-targeted-therapy
Schüler, E., et. al., Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 2017, 97(1), 195–203.Cancer, Radiation Oncologyprotocol development, Ultra-high dose rate irradiation (>50 Gy/s “FLASH”)cancer radiation-oncologyprotocol-development ultra-high-dose-rate-irradiation-50-gy-s-flash
Samykutty, A., et. al., Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging. Biotech Histochemistry, 2018, 93(8), 608-614.Breast Cancer, CancerDetection and monitoring of breast cancer by a osteopontin-NIR fluorophore conjugatebreast-cancer cancerdetection-and-monitoring-of-breast-cancer-by-a-osteopontin-nir-fluorophore-conjugate
Rice, M.A., et. al., Loss of Notch1 activity inhibits prostate cancer growth and metastasis and sensitizes prostate cancer cells to antiandrogen therapies. Molecular Cancer Therapeutics, 2019, 18(7): 1230–1242.Cancer, Prostate CancerNOTCH1 and Notch1 activity as therapeutic targets of aggressive prostate cancercancer prostate-cancernotch1-and-notch1-activity-as-therapeutic-targets-of-aggressive-prostate-cancer
Qiu, X.Y., et. al., PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. BBA – Molecular Basis of Disease, 2018, 1864: 1754-1769Cancer, GlioblastomaProgrammed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme malignancycancer glioblastomaprogrammed-cell-death-ligand-1-pd-l1-expression-level-correlated-with-glioblastoma-multiforme-malignancy
Phuong, P.T.T., et. al., Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy. Colloids and Surfaces B: Biointerfaces, 2018, 171: 123-133.Breast Cancer, CancerBreast tumor ablation by photodynamic therapybreast-cancer cancerbreast-tumor-ablation-by-photodynamic-therapy
Park, S.B., et. al., Bioluminescence imaging of matrix metalloproteinases-2 and -9 activities in ethanol-injured cornea of mice. In vivo, 2021, 35: 1521-1528.Eye Corneal Injury and HealingNon-invasive monitoring eye corneal injury and healingeye-corneal-injury-and-healingnon-invasive-monitoring-eye-corneal-injury-and-healing
Park, S., et. al., Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation. Journal of Controlled Release, 2019, 304: 7-18.Cancer, Colon CancerTumor Detection and Ablation by hybrid gold nanoclusters (AuNCs)cancer colon-cancertumor-detection-and-ablation-by-hybrid-gold-nanoclusters-auncs
Park, J., et. al., Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceuticals, 2019 May, 16(5): 1864-1873.Breast Cancer, CancerImproving NP delivery to tumor micro environment (TME)breast-cancer cancerimproving-np-delivery-to-tumor-micro-environment-tme
Pandurangi, R.S., et. al., A priori activation of apoptosis pathways of tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment, PLoS ONE, 2021, 16(2).Cancer, variousA priori activation of apoptosis pathways of tumor technology (AAAPT)cancer variousa-priori-activation-of-apoptosis-pathways-of-tumor-technology-aaapt
Padi, S.K.R., et. al., Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 2017, 77(s13): 5820–5820.Cancer, T-cell Acute Lymphoblastic Leukemiaspan-PIM Protein Kinase Inhibitor and Ponatinib vs.T-cell acute lymphoblastic leukemia subgroupcancer t-cell-acute-lymphoblastic-leukemiaspan-pim-protein-kinase-inhibitor-and-ponatinib-vs-t-cell-acute-lymphoblastic-leukemia-subgroup
O’Leary, M.P., et. al., Novel oncolytic chemeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose. Journal of Translational Medicine, 2018, 16:110.Cancer, Pancreatic CancerOncolytic viral therapy vs. Pancreatic Cancercancer pancreatic-canceroncolytic-viral-therapy-vs-pancreatic-cancer
O’Leary, M.P., et. al., A novel oncolytic chimeric orthopoxvirus encoding luciferase enable real-time view of colorectal cancer cell infection. Molecular Therapy Oncolytics, June 2018, 9: 13-21.Cancer, Colorectal CancerOncolytic viral therapy vs. Colorectal Cancercancer colorectal-canceroncolytic-viral-therapy-vs-colorectal-cancer
O’Leary, B.R., et. al., Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 2020, 10: 17649Cancer, Pancreatic CancerPharmacological ascorbate treatment of pancreatic ductal adenocarcinoma (PDAC)cancer pancreatic-cancerpharmacological-ascorbate-treatment-of-pancreatic-ductal-adenocarcinoma-pdac
O’Leary, B.R., et. al., Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma, AARC, Clinical Cancer Research, January 29, 2015.Cancer, Pancreatic CancerExtracellular Superoxide Dismutase (SOD) as therapeutic target for treatment of pancreatic adenocarcinoma (PDA)cancer pancreatic-cancerextracellular-superoxide-dismutase-sod-as-therapeutic-target-for-treatment-of-pancreatic-adenocarcinoma-pda
Nishihara, R., et. al., Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo. Theranostics, 2019, 9(9): 2646-2661.Breast Cancer, CancerNIR-BRET probes for in vivo monitoring of tumor metastases, protein-protein interactionsbreast-cancer cancernir-bret-probes-for-in-vivo-monitoring-of-tumor-metastases protein-protein-interactions
Moose, D.L., et. al., Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 2020, 30: 1-11.Cancer, Prostate CancerMechanism of Resilience of circulating tumor cells (CTCs)cancer prostate-cancermechanism-of-resilience-of-circulating-tumor-cells-ctcs
Meng, F., et. al., Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited, ACS Nano, 2018, July 24, 12(7): 6458-6468.Fluorescence ImagingFluorescence signal quenching in fluorophore-loaded nanoparticlesfluorescence-imagingfluorescence-signal-quenching-in-fluorophore-loaded-nanoparticles
Marecic, O., et al., Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 2015, 112(32): 9920–9925.Bone Growth, Repaircartilage, Distinct gene expression and phenotype of fracture-induced bone, stromal progenitor (f-BCSP) cellsbone-growth repaircartilage distinct-gene-expression-and-phenotype-of-fracture-induced-bone stromal-progenitor-f-bcsp-cells
Marchal, M.A., et. al., Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis. bioRxiv, 2020.Cancer, Prostate CancerMetastatic castration-resistant prostate cancer (mCRPC)cancer prostate-cancermetastatic-castration-resistant-prostate-cancer-mcrpc
Lucero-Acuña A., et. al., Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014,1: 5653–5665.Cancer, Pancreatic CancerOvercoming Severe Desmoplasiacancer pancreatic-cancerovercoming-severe-desmoplasia
Liu, M., et. al., Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 2015, 195(10): 5055–5065.Cancer, Lung cancerM2 to M1 activated macrophage conversioncancer lung-cancerm2-to-m1-activated-macrophage-conversion
Ling, Q., et. al., The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 2017, 8(9): 15159–15167.Cancer, PancreaticAssociated miRNA expression on PDAC recurrence, Prognostic relevance of primary PDAC locationcancer pancreaticassociated-mirna-expression-on-pdac-recurrence prognostic-relevance-of-primary-pdac-location
Li, Y., et. al., Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of Immunology, 2015, 194(3): 1011-1020.Cancer, LymphomaGVHD prevention and GVT preservation by helminth injection associated induction of Tregscancer lymphomagvhd-prevention-and-gvt-preservation-by-helminth-injection-associated-induction-of-tregs
Li, S., et. al., Near infrared fluorescent imaging of brain tumor with !R780 dye incorporated phospholipid nanoparticles, Journal of Translational Medicine, 2017, 15:18Cancer, GlioblastomaImage guided oncological surgery, Tumor Detectioncancer glioblastomaimage-guided-oncological-surgery tumor-detection
Lee, S.Y., et. al., Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma. Biomaterials Science, 2019.Cancer, Lung cancerNanoparticle drug delivery optimizationcancer lung-cancernanoparticle-drug-delivery-optimization
Lee, S.Y., et. al., An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy. Drug Delivery, 2018, 25(1): 738-749.Breast Cancer, CancerNanoparticle enzyme-based therapeuticbreast-cancer cancernanoparticle-enzyme-based-therapeutic
Lee, S.Y., et. al., Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the bloodstream and improved lung targeting efficiency. Journal of Colloid and Interface Science, 2016, 480: 102–108.Cancer, Lung cancerNanoparticle drug delivery optimizationcancer lung-cancernanoparticle-drug-delivery-optimization
Lee, J.J., et. al., Predictive modeling of in vivo response to gemcitabine in pancreatic cancer. PLoS Computational Biology, 2013, 9(9).Cancer, Pancreatic CancerPredictive limits of in vitro drug efficacy studiescancer pancreatic-cancerpredictive-limits-of-in-vitro-drug-efficacy-studies
Lartey, F.M., et. al., Dynamic CT imaging of volumetric changes in pulmonary nodules correlates with physical measurements of stiffness. Radiotherapy Oncology, 2017 February, 122(2): 313-318.Cancer, Lung cancerNon-invasive scanningXRAYRatAmi HTXBilly W. Loo, and Peter G. Maxim, Stanford University School of Medicine, Stanford, CA, USA2017Lung cancer: non-invasive screening, X-ray guided tumor cell injections, pulmonary nodule stiffness or deformability, correlation with pulmonary nodule (PN) volume ratio, technologies used: PN stiffness: Young’s modulus using atomic force microscopy, PN volume ratio: respiratory-gated MicroCT, Probe: None, X-ray imagingcancer lung-cancernon-invasive-scanning
Lahiji, S.F., et. al., Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth, Biomaterials, 2018.Androgenetic AlopeciaHair regrowth modelandrogenetic-alopeciahair-regrowth-model
Kumar, G.D., et. al., Modified coring tool designs reduce iceberg lettuce cross-contamination. Journal of Food Protection, 2019, 82(3): 454–462.Plant PathogensCrop harvestingplant-pathogenscrop-harvesting
Kimbrough, C.W., et. al., Targeting acidity in pancreatic adenocarcinoma: Multispectral optoacoustic tomography detects pH-low insertion peptide probes in vivo. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2015, 21(20): 4576–4585.Cancer, Pancreatic CancerpH-low insertion peptides as TME-specific probecancer pancreatic-cancerph-low-insertion-peptides-as-tme-specific-probe
Kimbrough, C.W., et. al., Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 2015, 193(1): 246–254.Cancer, Pancreatic CancerFLI and MSOT Detection Assaycancer pancreatic-cancerfli-and-msot-detection-assay
Ke, B., et. al., In vivo bioluminescence imaging of cobalt accumulation in a mouse model. Analytical Chemistry, 2018, 90: 4946-4950.Cobalt, Trace Element Nutrient TrackingBLI Detection Assaycobalt trace-element-nutrient-trackingbli-detection-assay
Kang, Y.Y., et. al., Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain, Phytomedicine, 2019, 62.Central Nervous System, InflammationCombinatorial drug synergistic efficacycentral-nervous-system inflammationcombinatorial-drug-synergistic-efficacy
Kaemmer, C.A., et. al., Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis. Nature Portfolio: Scientific Reports, 2021, 11.Cancer, Pancreatic CancerPancreatic neuroendocrine neoplasms (pNENs), preclinical BLI model developmentcancer pancreatic-cancerpancreatic-neuroendocrine-neoplasms-pnens preclinical-bli-model-development
Johnson, J., et. al., Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 2015, 13(1): 306.Cancer, GlioblastomaGenomic profiling of MET-inhibitor sensitive glioblastoma cell linescancer glioblastomagenomic-profiling-of-met-inhibitor-sensitive-glioblastoma-cell-lines
Jeffery, J.J., et. al., Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 2014, 239(4): 404–413.Breast Cancer, CancerBreast cancer bone metastases preventionbreast-cancer cancerbreast-cancer-bone-metastases-prevention
Ippen, F.M., et. al., The dual PI3K/mTOR pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2019, 25(11): 3374–3383.Breast Cancer, CancerBreast cancer brain metastases treatmentbreast-cancer cancerbreast-cancer-brain-metastases-treatment
Hudson, S.V., et. al., Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer Research, 2014, 74(21): 6271–6279.Cancer, Pancreatic CancerPancreatic cancer specific NIR fluorescent probecancer pancreatic-cancerpancreatic-cancer-specific-nir-fluorescent-probe
Huang, J., et. al., An activatable near-infrared chromophore for multispectral optoacoustic imaging of tumor hypoxia and for tumor inhibition, Theranostics, 2019, 9(24):7313-7324.Cancer, Tumor HypoxiaHypoxia-specific NIR activateable probe conjugated to DNA-binding therapeuticcancer tumor-hypoxiahypoxia-specific-nir-activateable-probe-conjugated-to-dna-binding-therapeutic
Huang, D., et. al., Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle. Acta Biomaterialia, 2020.Duchenne muscular dystrophy (DMD)Muscle growth and repairduchenne-muscular-dystrophy-dmdmuscle-growth-and-repair
Hipsch, M., et. al., Sensing stress responses in potato with whole-plant redox imaging. Plant Physiology, 2021.Radical Oxygen Species (ROS)Plant Oxidative Stressradical-oxygen-species-rosplant-oxidative-stress
Heo, R., et. al., Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis, Biomaterials, 2017.Autoimmunity, Rheumatoid ArthritisTherapeutic delivery by Nanoparticlesautoimmunity rheumatoid-arthritistherapeutic-delivery-by-nanoparticles
Henry, M.D., et. al., Comparison of high sensitivity BLI imaging systems for ultra-weak signal applications. (Conference poster).Bioluminescent ImagingSignal calibration across field of view (FOV)bioluminescent-imagingsignal-calibration-across-field-of-view-fov
Hardy, S.D. et. al., Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 2017, 8(61): 103302–103314.Breast Cancer, CancerMolecular Biology of Epithelial Mesenchymal transition (EMT)breast-cancer cancermolecular-biology-of-epithelial-mesenchymal-transition-emt
Han, N., et. al., Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics, 2017, 14(5): 1538–1547.Nanoparticle delivery systemsNP targeting of tumor microenvironment (TME)nanoparticle-delivery-systemsnp-targeting-of-tumor-microenvironment-tme
Haber, Z., et. al., Resolving diurnal dynamics of the chloroplastic glutathione redox state in Arabidopsis reveals its photosynthetically-derived oxidation, The Plant Cell, 2021.Radical Oxygen Species (ROS)Plant Oxidative Stressradical-oxygen-species-rosplant-oxidative-stress
Feng, X., et. al., Responsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals. Chemistry, An Asian Journal, 2018, 10.1002/asia.201800957Radical Oxygen Species (ROS)ROS detection by fluorescence imagingradical-oxygen-species-rosros-detection-by-fluorescence-imaging
Feng, X., et. al., Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 2017, 385: 12–20.Cancer, Glioblastomare-angiogenesis, Tumor recurrencecancer glioblastomare-angiogenesis tumor-recurrence
Fan, Q., et. al., Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy, Journal of Controlled Release, 2019, 302: 63-78.Cancer, SarcomaTumor vascular normalizationcancer sarcomatumor-vascular-normalization
England, C.G., et. al., Detection of phosphatidylcholine-coated gold nanoparticles in orthotopic pancreatic adenocarcinoma using hyperspectral imaging. PloS one, 2015, 10(6).Cancer, Pancreatic CancerNanoparticle intra-tumoral penetrationcancer pancreatic-cancernanoparticle-intra-tumoral-penetration
England, C.G., et. al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor. (Conference poster).XRAY ImagingAnimal safety, OncogenesisBLI, XRAYMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USAnaSafety of in vivo X-Ray Imaging: Oncogenesis, Pancreatic Cancer, Probe: luciferasexray-imaginganimal-safety oncogenesis
Elattar, S., et. al., The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. The FASEB Journal, 2018, 32: 4727–4743.CachexiaCachexia molecular, therapeutic targetcachexiacachexia-molecular therapeutic-target
Dykstra, M., et. al., In vitro and in vivo studies of cerenkov luminescence imaging. (Conference poster).Cerenkov ImagingCerenkov Imaging with Optical Imagercerenkov-imagingcerenkov-imaging-with-optical-imager
Dassie, J.P., et. al., Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 2014, 22(11): 1910–1922.Cancer, Pancreatic CancerMetastases Inhibitioncancer pancreatic-cancermetastases-inhibition
Dann, T., et. al., Anatase titanium dioxide imparts photoluminescent properties to PA2200 commercial 3D printing material to generate complex optical imaging phantoms. Materials, 2021, 14(7): 1813.Imaging PhantomsPhotoluminescent 3D-print phantomsimaging-phantomsphotoluminescent-3d-print-phantoms
Connolly, R.J., et. al., Development of a catheter-based applicator for immuno-oncology. (Conference Poster).Cancer, MelanomaImmunotherapyBLIMouseLagoRobert H. Pierce, OncoSec Medical Incorporated, San Diego, CA, USAnaMelanoma: Immuno-oncology, immunotherapy, electroporation, catheter, intratumoral delivery of cytokine encoding plasmids, IL-12, Probe: luciferasecancer melanomaimmunotherapy
Chaurasiya, S., et. al., Toward comprehensive imaging of oncolytic viroimmunotherapy, Molecular Therapy: Oncolytics, 2021variousViral oncolytic therapyvariousviral-oncolytic-therapy
Buchakjian, M.R., et al., Development of a Tongue Carcinoma Model Using Real-Time In Vivo Molecular Monitoring. (Conference Poster).Cancer, SarcomaOncogenesiscancer sarcomaoncogenesis
Buchakjian, M.R., et. al., A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS One, 2017, 12(8).Cancer, SarcomaOncogenesiscancer sarcomaoncogenesis
Borin, T.F., et. al., HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS One, 2017, 12(6).Breast Cancer, CancerImmunotherapybreast-cancer cancerimmunotherapy
Bhutiani, N., et. al., Detection of microspheres in vivo using multispectral optoacoustic tomography. Biotech Histochemistry, 2017, 92(1): 1–6.Nanoparticles (NPs)NIRF labeling of NPsnanoparticles-npsnirf-labeling-of-nps
Bahrami, A.J., et. al., A novel approach for endoscopic gene transfer. (Conference Poster), 2017.Cancer, MelanomaImmunotherapycancer melanomaimmunotherapy
Au, K.M., et. al., Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin’s lymphoma. Science Advances, 2020, 6: 1-12.Cancer, Non-Hodgkin's LymphomaB Cell Receptor transduction cascade regulationcancer non-hodgkins-lymphomab-cell-receptor-transduction-cascade-regulation
Alizadeh, D., et. al., INFɣ is Critical for CAR T cell mediated myeloid activation and induction of endogenous immunity. Cancer Discovery, 2021, 11(9): 2248-2265.Cancer, GlioblastomaImmunotherapycancer glioblastomaimmunotherapy
Alizadeh, D., et. al., Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 2014, 74(1): 104–118.Breast Cancer, CancerImmunotherapybreast-cancer cancerimmunotherapy
Alexander, M.S., et. al., A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. Journal of Biological Methods, 2018, 5(3): 1-7.Cancer, Pancreatic CancerMetastases formationcancer pancreatic-cancermetastases-formation
Achyut, B.R., et. al., Chimeric mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 2016, 17(3): 280–290.Cancer, Pancreatic CancerAntiangiogenic resistancecancer pancreatic-cancerantiangiogenic-resistance
Achyut, B.R., et. al., Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 2015, 369(2): 416–426.Cancer, GlioblastomaAntiangiogenic resistancecancer glioblastomaantiangiogenic-resistance

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