Publications

Acute Lymphoblastic Leukemia

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Various, patient-derived T-ALL cells (acute lyphoblastic leukemia T-cells)


Song, J.H. & Kraft, A.S., 2016. Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 76(s14), pp.4414–4414.

Breast Cancer

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Alizadeh, Darya et al., 2014. Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 74(1), pp.104–118.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Borin, T.F. et al., 2017. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS one, 12(6), p.e0178830.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 4TI cells


Hardy, S.D. et al., 2017. Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 8(61), pp.103302–103314.

Breast Cancer with Bone Metastases

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: breast-cancer, bone-homing clone: MDA-MB-231-BO


Jeffery, J.J. et al., 2014. Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 239(4), pp.404–413.

Breast Cancer with Glioblastoma Metastases

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived, PIK3CA-mutant cells


Ippen, F.M. et al., 2019. The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(11), pp.3374–3383.

Circulating Tumor Cells

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: PC-3 prostate cancer cells


Moose, D.L. et al., 2020. Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 30, pp. 1-11.

Colon Cancer

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Modality: FLI  |  Probe(s): DiR  |  Animal Model: Mouse

Cell line: LS174T cells


Han, N. et al., 2017. Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Molecular pharmaceutics, 14(5), pp.1538–1547.

Colorectal Cancer

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Modality: FLI  |  Probe(s): IR700 Dye  |  Animal Model: Mouse

Cell line: Patient-derived LS174T cells


Shi, Q. et al., 2017. PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 24(1), pp.1818–1830.

Glioblastoma

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Modality: FLI  |  Probe(s): GFP  |  Animal Model: Mouse

Cell line: U251 glioma


Achyut, B.R. et al., 2015. Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 369(2), 416–426.

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Modality: FLI  |  Probe(s): GFP  |  Animal Model: Mouse

Cell line: U251 glioma


Achyut, B.R. et al., 2016. Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 17(3), pp.280–290.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: U87 cells cocultured with HUVEC-Fluc, or HMEC-1-Fluc


Feng, X. et al., 2017. Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 385, pp.12–20.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: patient-derived, normal/elevated hepatocyte GF cells


Johnson, J. et al., 2015. Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 13(1), p.306.

IDH-mutant Glioma

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived U87-luc, and MGG152-luc (IDH1-mutant)


Shankar, G.M. et al., 2018. Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 115(36), pp.E8388–E8394.

Intraoperative Tumor Detection Methods

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Modality: BLI/FLI  |  Probe(s): Luciferase/ICG  |  Animal Model: Rat

Cell line: Patient-derived glioma C6 cells


Watson, J.R. 2016 Intraoperative imaging using intravascular contrast agent. Proceedings. 96960L.

Leukemia

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Helminth (H. polygyrus); BALB/c mice received total splenic T cells and TCD BM cells from uninfected donor C57BL/6 mice


Li, Y. et al., 2015. Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of immunology (Baltimore, Md. : 1950), 194(3), pp.1011–1020.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: CAF1/J mice received T-cell depleted h-BMT or h-BMT/SC from CB6F1 mic


Stokes, J. et al., 2016. Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 174(1), pp.102–116.

Lung Cancer

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Modality: Dual FLI  |  Probe(s): XenoLight DiR and VivoTrack 680  |  Animal Model: Mouse

Cell line: LLC cells


Liu, M. et al., 2015. Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 195(10), pp.5055–5065.

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Modality: BLI  |  Probe(s): Luciferase |  Animal Model: Mouse

Cell line: Patient-derived A549 cells; H358 cells, 293 T cells


Yadav, S. et al., 2017. MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 19(4), pp.321–332.

Melanoma

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: intratumoral plasmid gene delivery


Barrami, A.J. et al., 2017. A novel approach for endoscopic gene transfer

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: intratumoral plasmid gene delivery


Connolly, R.J. et al. Development of a catheter-based applicator for immuno-oncology

Nanoparticle: Drug Delivery to Tumor

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S2-VP10 cells


England, C.G. et al., 2015. Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging. PloS one, 10(6), p.e0129172.

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Modality: FLI  |  Probe(s): Cy5.5  |  Animal Model: Mouse

Cell line: N/A


Lee, S. Y. et al., 2016. Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency. Journal of Colloid And Interface Science, 480, pp.102–108.

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Modality: FLI  |  Probe(s): Cy5.5  |  Animal Model: Mouse

Cell line: PC-3 cells


Yoon, H. Y. et al., 2014. Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 4(1), p.6878.

Nanoparticle: Optimized Tumor Detection

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Modality: FLI  |  Probe(s): IR-780 dye (see supplemental figures)  |  Animal Model: Mouse

Cell line: S2-VP10 cells


Zeiderman, M.R. et al., 2016. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2(7), pp.1108–1120.

Pancreatic Adenocarcinoma

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Modality: BLI, FLI  |  Probe(s): Luciferase, 750  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10 cells


Yin, W et al., 2016.Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences Senior Honors Theses. Paper 126.

Pancreatic Cancer

Poster


Modality: BLI/X-Ray  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S2-VP10 cells


England, C.G et al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor

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Modality: BLI, FLI  |  Probe(s): Luciferase, CF-750  |  Animal Model: Mouse

Cell line: S2VP10 cells


Hudson, S.V. et al., 2014. Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer research, 74(21), pp.6271–6279.

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Modality: BLI, FLI  |  Probe(s): luciferase, NIR dye  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10 and S2VP10L cells


Kimbrough, C.W. et al., 2015. Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 193(1), pp.246–254.

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10L and MiaPaCa-2 cells


Lee, J. et al., 2013. Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer. PLoS Computational Biology, 9(9), p.e1003231.

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived MiaPaCa cells


Lucero-Acuña A et al., 2014. Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014(Issue 1), pp.5653–5665.

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Modality: BLI  |  Probe(s): luciferase  |  Animal Model: Mouse

Cell line: Patient-derived MiaPaCa-2, BxPc3, and Panc-1cells


Wen, F. et al., 2013. Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 73(14), pp.4256–4266.

Pancreatic Ductal Adenocarcinoma

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Modality: BLI, FLI  |  Probe(s): Luciferase, 750 NIR fluorescent dye  |  Animal Model: Mouse

Cell line: Patient-derived S2VP10L and S2013Q cells


Kimbrough, Charles W et al., 2015. Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), pp.4576–4585.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Panc-1/Luc cells


Ling, Q. et al., 2017. The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 8(9), pp.15159–15167.

Prostate Cancer

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Modality: BLI, FLI  |  Probe(s): Luciferase, IRDye 800 CW  |  Animal Model: Mouse

Cell line: PC3 (PSMA++) cells


Dassie et al., 2014. Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 22(11), pp.1910–1922.

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived 22RV1-Luc or Delta-Notch1-Luc cell lines


Rice, M.A. et al., 2019. Loss of Notch1 Activity Inhibits Prostate Cancer Growth and Metastasis and Sensitizes Prostate Cancer Cells to Antiandrogen Therapies. Molecular cancer therapeutics, 18(7), pp.1230–1242.

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Modality: BLI/FLI  |  Probe(s): Luciferase, GFP  |  Animal Model: Mouse

Cell line: Patient-derived PC3 and DU145 cells


Varzavand, A. et al., 2016. α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer research, 76(22), pp.6577–6587.

Sarcoma

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Viral-mediated Trp53/Pten knock out


Buchakjian, M.R. et al., 2017. A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS ONE, 12(8), p.e0183469.

T-Cell Acute Lymphoblastic Leukemia

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Patient-derived ETP-ALL cell lines


Padi, S.K.R. et al., 2017. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 77(s13), pp.5820–5820.

Tongue Carcinoma

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: Viral-mediated Trp53/Pten knock out


Buchakjian, M.R. et al., Trp53 PTEN Inducible knockout mice and viral delivery techniques

Immune Response

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: S. aureus cells


Chen, W. et al., 2017. Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus. Biomaterials, 143, pp.46–56.

Nanoparticle: Drug-Eluting Bone Joint Implant

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Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Rabbit

Cell line: S. aureus cells


Suhardi et al., 2017. A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. 2017. “A Fully Functional Drug-Eluting Joint Implant.” Nature biomedical engineering 1 (1): 0080. doi:10.1038/s41551–017-0080. http://dx.doi.org/10.1038/s41551–017-0080.

Healing of a Femoral Fracture

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Modality: X-Ray  |  Probe(s): N/A  |  Animal Model: Mouse


Marecic, O et al., 2015. Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 112(32), pp.9920–9925.

Bioluminescent Imaging

Poster


Modality: BLI  |  Probe(s): Luciferase  |  Animal Model: Mouse

Cell line: 22Rv1.lucPN2, viral-mediated Trp53/Pten knock out


Henry, M.D. et al., Comparison of High Sensitivity BLI Imaging Systems for Ultra-weak Signal Applications

Cerenkov Luminescent Imaging

Poster


Modality: CLI  |  Probe(s): Cerenkov  |  Animal Model: Mouse

Cell line: N/A


Dykstra, M. et al., In vitro and in vivo studies of cerenkov luminescence imaging

X-Ray Imaging

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Modality: N/A  |  Probe(s): X-Ray  |  Animal Model: Mouse

Cell line: N/A


Schüler, E. et al., 2017. Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 97(1), pp.195–203.

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