Publications

Impactful Publications in Key Applications

No Data Found

0
Pancreatic Cancer
0
Breast Cancer
0
Glioblastoma
0
Prostate Cancer
Publication ReferenceGeneral Research CategorySpecific Research CategoryModalityModelSystemCorresponding Authors And InstitutionDateLinkKey Summaryhf:doc_categorieshf:doc_tags
Zhong, Y., et. al., Co-administration of of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment. International Journal of Nanomedicine, 2019, 14: 8543–8560.Cancer, Colorectal CancerNanoparticle (NP) therapeutic delivery for colorectal cancer:FLIMouseLago X1-Shan Liu, and 2-Hao Yang, 1-Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China, 2-West China Hospital, Sichuan University, Chengdu, China2019Nanoparticle (NP) therapeutic delivery for colorectal cancer: Tumor targeting of Paclitaxel (PTX)-loaded PLGA nanoparticles (PLGA-PTX) was enhanced by co-administered iRGD. Note: iRGD is a bifunctional peptide ligand containing a tumor-homing motif (RGD) and a tissue-penetrating motif (CendR). Once bound to tumor-associated iRGD sites, binding to CendR enhances tumor membrane permeability, elevating NP transport across membrane., Probe: DiDcancer colorectal-cancernanoparticle-np-therapeutic-delivery-for-colorectal-cancer
Zhong, Q., et. al., Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters, Biomaterials, June 2020, 206: 73-86.Therapeutic Drug DeliveryUltrasound-activated drug-loaded nanoemulsionsFLIRatLagoRaag Airan, Stanford University, Stanford, CA, USA2020Ultrasound-activated drug-loaded nanoemulsions: Chemistries determined and a generalized production platform developed for polymeric perfluorocarbon nanoemulsions designed to cage a wide array of hydrophobic drugs, released by ultrasound signal, with a high potential for clinical translation, Probe: IR 800therapeutic-drug-deliveryultrasound-activated-drug-loaded-nanoemulsions
Zeiderman, M.R., et. al., Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS biomaterials science & engineering, 2016, 2(7), 1108–1120.Cancer, Pancreatic CancerPancreatic tumor detection and treatment with novel theranostic particlesFLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2016Pancreatic tumor detection and treatment with novel theranostic particles: Authors developed an acidic pH-targeted, chitosan capped, mesoporous silica (MS), gold nanorods (MS-GNRs) as both a tumor-targeting and drug-delivering nanoparticle (NP), with a NIR signals for sensitive optoacoustic (OA) imaging. Details on NP structure: MS protected the GNRs from thermal deformation, enhanced GNR thermal stability, and increased OA signal. Tumor-specific release of test therapeutic, gemcitabine, was mediated by two NP "gate keepers:" chitosan and a variant 7 of low pH insertion proteins (V7-LpHIPs), where chitosan and V7-LpHIP changed conformation in the presence of tumor micro enviroment's low pH. NIR signals of the NPs were provided by loaded IR-780 perchlorate dye and gold nanorods, Probes: luciferase, IR-780 dye (see supplemental figures)cancer pancreatic-cancerpancreatic-tumor-detection-and-treatment-with-novel-theranostic-particles
Yuan, G., et. al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, 2021, 590(7846), 504-508.Cancer, Lung cancerLung squamous cell carcinoma (LUSC) tumorigenesisBLIMouseAmi HTX1-Ning-Yi Shao, 2-Łukasz Jaremko, 3-Pawel K. Mazur, and 4-Or Gozani, 1-University of Macau, Macau SAR, China, 2-King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, 3-The University of Texas MD Anderson Cancer Center, Houston, TX, USA, and 4-Stanford University, Stanford, CA, USA2021Lung squamous cell carcinoma (LUSC) tumorigenesis: Histone H3 lysine 36 (H3K36) methyltransferase NSD3 (located in the 8p11–12 amplicon) was identified as a key regulator of LUSC tumorigenesis. Specifically, a LUSC-associated variant NSD3 (T1232A) showed increased catalytic activity for dimethylation of H3K36 (H3K36me2) and was found to drive LUSC tumorigenesis, Probes: luciferase, akaLuccancer lung-cancerlung-squamous-cell-carcinoma-lusc-tumorigenesis
Yoon, H.Y., et. al., Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports, 2014, 4(1), 6878.Cancer, Prostate CancerGlycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehiclesFLIMouseAmi HTX1-Kwangmeyung Kim and 2-Martin G. Pomper, 1-Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea, 2-Johns Hopkins School of Medicine, Baltimore, MD, USA2014Glycol chitosan nanoparticles (CNPs) as specialized cancer therapeutic vehicles: Authors developed CNPs loaded with both doxorubicin (DOX) and Bcl-2 siRNA. These dual-therapeutic,loaded CNPs effectively reduced prostate tumor load in a mouse model, Probe: Cy5.5cancer prostate-cancerglycol-chitosan-nanoparticles-cnps-as-specialized-cancer-therapeutic-vehicles
Yong, C., et. al., Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS ONE, 2020, 15(9).Cancer, Prostate CancerCastration resistant invasive prostate cancerBLIMouseAmi HTXMichael D. Henry, University of Iowa, Iowa City, IA, USA2020Castration resistant, invasive prostate cancer: A Pten/Trp53 double knockout mouse model of castrate resistant, invasive prostate cancer was monitored with non-invasive bioluminescent imaging. This model was set up by employing a Probasin-Cre mediated deletion of Pten and Trp53, coupled with the activation of a ROSA-LSL luciferase reporter., Probe: luciferasecancer prostate-cancercastration-resistant-invasive-prostate-cancer
Yin, W., et. al., Syndecan-1 tagged liposomes as a theranostic nanoparticle for pancreatic adenocarcinoma. College of Arts & Sciences, Senior Honors Theses, 2016, Paper 126.Cancer, Pancreatic CancerDirected-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinomaFLI, BLIMouseAmi HTXWenyuan Yin, University of Louisville, Louisville, KY, USA2016Directed-liposome as a theranostic nanoparticle, and a therapeutic delivery mechanism for pancreatic adenocarcinoma: A syndecan-1-tagged liposome, loaded with fluorescent dye, achieved both specific pharmacokinetics to and non-invasive detection of orthotopic pancreatic cancer, as determined by multispectral optoacoustic tomography, Probes: luciferase, CF-750cancer pancreatic-cancerdirected-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma
Yin, W., et. al., Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography, Journal of Nanobiotechnology, 2015, 13:90.Cancer, Pancreatic CancerDirected-liposome as a theranostic nanoparticle, Therapeutic delivery mechanism for pancreatic adenocarcinomaFLI, BLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2015Directed-liposome as a theranostic nanoparticle, and a therapeutic delivery mechanism for pancreatic adenocarcinoma: A syndecan-1-tagged liposome, loaded with fluorescent dye, achieved both specific pharmacokinetics to and non-invasive detection of orthotopic pancreatic cancer, as determined by multispectral optoacoustic tomography, Probes: CF-750, propidium iodide, luciferasecancer pancreatic-cancerdirected-liposome-as-a-theranostic-nanoparticle therapeutic-delivery-mechanism-for-pancreatic-adenocarcinoma
Yang, H., et. al., Endogenous IgG-based affinity-controlled release of TRAIL exerts superior antitumor effects, Theranostics, 2018, 8(9): 2459-2476.Cancer, Colorectal CancerTRAIL in vivo pharmacokinetics optimized for superior antitumor efficacyFLIMouseLago XXiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China2018TRAIL in vivo pharmacokinetics optimized for superior antitumor efficacy: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was fused to endogenous IgG binding domain (IgGBD) moiety to enhance serum half-life, without any steric hindrance of TRAIL binding to its apoptosis-inducing site on tumors. In vivo trials showed that IgG-based affinity-controlled release of IgBD-TRAIL, did indeed lead to greater serum half-life and anti-tumor efficacy of TRAIL moiety. , Probe: CF750cancer colorectal-cancertrail-in-vivo-pharmacokinetics-optimized-for-superior-antitumor-efficacy
Yadav, S., et. al., MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. Neoplasia, 2017, Vol. 19, No. 4, pp. 321-332Cancer, Lung cancermiRNA-mediated loss of Ubiquilin protein expressionFLI, BLIMouseAmi HT1,2-Sanjay Yadav and Levi J. Beverly, 1-University of Louisville, Louisville, KY, USA, 2-CSIR-Indian Institute of Toxicology Research, Lucknow, India2017miRNA-mediated loss of Ubiquilin protein expression: An increase in miRNA expression (specifically MIR155) increased lung cell invasion, migration, wound formation and clonogenicity in UBQLN-loss dependent manner. Background: Pollution carcinogen, diesel exhaust particles (DEP), found to upregulate Ubiquilin expression (and suppress MIR155 expression) and so initially protect lung cells; however, authors propose that "...DEP-induced repression of MIR155 leads to increased UBQLN levels, which in turn may be a selective pressure on lung cells to lose UBQLN1.", Probes: luciferase, GFPcancer lung-cancermirna-mediated-loss-of-ubiquilin-protein-expression
Wu, B., et. al., Oligo(ethylene glycol)-functionalized squaraine fluorophore as a near-infrared-fluorescent probe for the in vivo detection of diagnostic enzymes. Analytical Chemistry, 2018, 90:9359-9365.Cancer, Liver CancerIn vivo detection of tumor-associated diagnostic enzymesFLIMouseAmi HTFang Zeng and Shuizhu Wu, South China University of Technology, Guangzhou, China2018In vivo detection of tumor-associated, diagnostic enzymes: Leucine aminopeptidase (LAP), expressed at high levels in hepatomas, can function as a diagnostic enzyme, where an activatable, NIR squaraine fluorophore is specifically cleaved (and so activated) by LAP. Aqueous solubility (functionality) of this squaraine fluorophore has been improved by a oligo (ethylene glycol) addition, Probe: Oligo (ethylene glycol) modified Squaraine cancer liver-cancerin-vivo-detection-of-tumor-associated-diagnostic-enzymes
Wen, F., et. al., Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer research, 2013, 73(14), pp.4256–4266.Cancer, Pancreatic CancerExtracellular DNA promotes tumor-associated inflammation; cell invasion and aggressive metastasisBLIMouseAmi HT1-Fushi Wen and 2-Jiaqi Shi, 1-University of Arizona, Tucson, AZ, USA, 2-University of Michigan, Ann Arbor, MI, USA2013Extracellular DNA (ExDNA) promotes tumor-associated inflammation, cell invasion and aggressive metastasis: ExDNA containing fibers from neutrophils (nicknamed neutrophil extracellular traps or NETs found on the surface of pancreatic cancer cells, believed to be involved in inflammatory positive feedback loop (promoting expression of the inflammatory chemokine CXCL8 which led to more ExDNA), tumor growth and metastases suppressed by DNase 1 treatment, Probe: luciferasecancer pancreatic-cancerextracellular-dna-promotes-tumor-associated-inflammation-cell-invasion-and-aggressive-metastasis
Watson, J.R., et.al., Intraoperative imaging using intravascular contrast agent. Society of Photo-Optical Instrumentation Engineers, Conference Proceedings, 2016, Vol.9696.Cancer, GlioblastomaIntraoperative tumor detectionBLI, FLIRatLago XMarek Romanowski, University of Arizona, Tucson, AZ, USA2016Intraoperative tumor detection: Indocyanine green (ICG) tumor uptake by enhanced permeability and retention effect (EPR). Tumor surgical resection guided by ICG NIR fluorescent signal as viewed by augmented microscopy. ICG NIRF confirmed by bioluminescent signal of Luc-C6 glioblastoma used in rat model, Probes: luciferase, ICGcancer glioblastomaintraoperative-tumor-detection
Varzavand, A., et. al., α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer Research, 2016, 76(22), 6577–6587.Cancer, Prostate CancerProstate cancer metastasis regulationBLI, FLIMouseAmi XMichael D. Henry and Christopher S. Stipp, University of Iowa, Iowa City, IA, USA2016Prostate cancer metastasis regulation: Have identified an a3 integrin-Abl kinase-Hippo suppressor pathway in prostate cancer in which a3b1 integrin signals through Abl kinases to restrain Rho GTPase activity, sustain Hippo suppressor functions,and curtail metastatic cell phenotypes., Probes: luciferase, GFPcancer prostate-cancerprostate-cancer-metastasis-regulation
Tao, Z., et. al., Targeted delivery to tumor-associated pericytes via an affibody with high affinity for PDGFRβ enhances the in vivo antitumor effects of human TRAIL. Theranostics, 2017, 7(8): 2261-2276.Cancer, Colon CancerTumor-targeted hTRAIL therapyFLIMouseLago XXiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China2017Tumor-targeted hTRAIL therapy: Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) was fused to an affibody with high affinity for platelet-derived growth factor receptor β (PDGFRβ), which is expressed by pericytes that are enriched in tumor tissues. This affibody-mediated binding of hTRAIL to tumor cells did not interfere with hTRAIL's death receptor binding and activation, and indeed, tumor hTRAIL uptake and antitumor effect was increased in colorectal xenografts in mice, Probe: CF750cancer colon-cancertumor-targeted-htrail-therapy
Tang, A.C., et. al. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. Cell Death and Disease, 2018, 9:162.Cancer, haematological malignanciesCombination therapy of proteasome inhibitors and Toll-like receptor agonistsBLIMouseAmi HTXStuart E. Turvey, University of British Columbia, Vancouver, BC, Canada2018Combination therapy of proteasome inhibitors and TLR agonists: enhances tumour cell death and IL-1β production, Probe: GFP-luciferasecancer haematological-malignanciescombination-therapy-of-proteasome-inhibitors-and-toll-like-receptor-agonists
Sukumar, U.K., et. al., SP94-targeted triblock copolymer nanoparticle delivers thymidine kinase-p53-nitroreductase triple therapeutic gene and restores anticancer function against hepatocellular carcinoma in vivo. ACS Applied Material Interfaces, March 2020, 12(10): 11307-11319.Cancer, Hepatocellular CarcinomaGene-directed enzyme–prodrug therapy (GDEPT)BLI, FLIMouseLagoRamasamy Paulmurugan, Stanford University School of Medicine, Palo Alto, CA, USA2020Gene-directed enzyme–prodrug therapy (GDEPT): Used triblock copolymer NPs: Polyethylenimine (PEI) conjugated with poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) for non-toxic delivery of negative nucleic acids, and for delivery of a rationally engineered thymidine kinase (TK)–p53–nitroreductase (NTR) triple therapeutic to restore p53 function and potentiate cancer cell response to delivered prodrugs (ganciclovir (GCV) and CB1954) with expression of suicide genes (TK,NTR). Hepatocellular carcinoma (HCC) tumor-targeting of NPs achieved with addition of SP94 peptide, Probes: luciferase, CytoCy5cancer hepatocellular-carcinomagene-directed-enzyme-prodrug-therapy-gdept
Sukumar, U.K., et. al., Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to Temozolomide. Biomaterials, October 2019, 218.Cancer, GlioblastomaTheranostic; intranasal and systemic combinatorial therapy of GBMBLIMouseLago X1-Tarik F. Massoud and 2-Ramasamy Paulmurugan, 1-Stanford University School of Medicine, Stanford, CA, USA, 2-Stanford University School of Medicine, Palo Alto, CA, USA2019Theranostic, intranasal and systemic combinatorial therapy for GBM: use intranasal delivery of theranostic, polyfunctional gold-iron oxide nanoparticles (polyGIONs) surface-loaded with therapeutic Cy5-miRNAs (miR-100 and antimiR-21), along with systemically delivered chemotherapy drug temozolomide (TMZ), to treat orthotopic mouse model of FLUC-EGFP labeled U87-MG GBMs, Probes: luciferase, Cy5cancer glioblastomatheranostic-intranasal-and-systemic-combinatorial-therapy-of-gbm
Suhardi, V.J., et. al., A Fully Functional Drug-Eluting Joint Implant. Nature biomedical engineering, 1(6), pp.Suhardi, VJ, DA Bichara, SJJ Kwok, AA Freiberg, H Rubash, H Malchau, SH Yun, OK Muratoglu, and E Oral. Nat Biomed Eng. 2017, 1.Revision of Infected Prosthetic JointsAntibiotic drug delivery and mechanical strength of prosthetic joint implant materialBLIRabbitAmi HTX1,2-E Oral, 1-Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, MA, USA, and 2-Harvard Medical School, Cambridge, MA, USA2017Optimize joint implant antibiotic drug delivery and mechanical strength: Modified eccentricity of drug clusters and percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) to maximize drug elution rate while retaining UHMWPE mechanical strength. Lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects, outperforming the current clinical gold standard model of antibiotic-eluting bone cement joint construct, Probe: luciferaserevision-of-infected-prosthetic-jointsantibiotic-drug-delivery-and-mechanical-strength-of-prosthetic-joint-implant-material
Su, Y., et. al., Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals, Nature Methods, 2020, 17, 852–860.Bioluminescent ImagingDual Bioluminescence ImagingBLIMouseAmi HT1-Thomas A. Kirkland, and 2-Michael Z. Lin, 1-Promega Biosciences LLC, San Luis Obispo, CA, USA, 2-Stanford University, Stanford, CA, USA2020New Nanoluc substrate enhances dual in vivo bioluminescence imaging: Previously, Antares, a fusion of NanoLuc to the orange fluorescent protein CyOFP (an example of BRET) used with AkaLuc and its substrate AkaLumine to provide a dual biolum, as the two luciferases have orthogonal substrate specificity. NanoLuc bioluminescence brightness has been improved: first, with hydro-furimazine, and then even more so with fluorofurimazine. Used Antares with fluorofurimazine to track tumor size, AkaLuc/Akalumine to visualize CAR-T cells within the same mice, Probes: Antares, AkaLucbioluminescent-imagingdual-bioluminescence-imaging
Stokes, J., et. al., Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation. British Journal of Haematology, 2016, 174(1), 102–116.Cancer, LymphomaGVHD prevention and GVL preservationBLIMouseLagoEmmanuel Katsanis, University of Arizona, Tucson, AZ, USA2016GVHD prevention and GVL preservation: in cases of haploidentical bone marrow transplantation (h-BMT), achieved by post-transplant bendamustine treatment, Probe: luciferasecancer lymphomagvhd-prevention-and-gvl-preservation
Song, J.H. & Kraft, A.S., Insulin receptor substrate 1 is a key substrate for Pim protein kinases. Cancer Research, 2016, 76(s14), 4414–4414.Cancer, LymphomasPim Kinase substrates and associated regulatory pathwaysBLIMouseLago XJin H. Song, and Andrew S. Kraft, University of Arizona, Tucson, AZ, USA2016Haematopoietic malignancies: Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Therefore, aim to identify Pim substrates to determine pathways regulated by enzymes, and to have substrates serve as possible biomarkers of Pim kinase activity, Probe: luciferasecancer lymphomaspim-kinase-substrates-and-associated-regulatory-pathways
Shin, J.M., et. al., A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy. Biomaterials Research, 2018, 22:21.Cancer, Cervical CancerImmunotherapy by polymeric antigen carrierFLIMouseLago XJae Hyung Park, Sungkyunkwan University, Suwon, Republic of Korea2018Immunotherapy by polymeric antigen carrier: Carboxymethyl dextran (CMD) used as the polymeric backbone and ovalbumin (OVA) as a model foreign antigen, CMD-OVA conjugate successfully taken up by TC-1 cervical cancer in vivo, , Probe: Cy5.5cancer cervical-cancerimmunotherapy-by-polymeric-antigen-carrier
Shi, Q., et. al., PDGFR beta-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer. Drug Delivery, 2017, 24(1), pp.1818–1830.Cancer, Colorectal CancerPhotodynamic therapyFLIMouseLago XXiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China2017Photodynamic therapy (PDT) specificity enhanced by targeting vascular pericyte membrane protein, PDGFRb: Photosensitizer, IR700, conjugated to affibody directed against PDGFRb, showed binding specificity to tumor vascular PDGFRb in vivo. Ensuing PDT intensitied tumor specific hypoxia, and reduced in tumor mass vs. negative controls. Additionally, above PDT led to increased tumor uptake of TNF-related apoptosis-inducing ligand (TRAIL) injected post-illumination. This dual therapy showed greater tumor suppression than either mono-therapy, Probe: IR700 cancer colorectal-cancerphotodynamic-therapy
Shankar, G.M., et. al., Genotype-targeted local therapy of glioma. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(36), E8388–E8394.Cancer, GlioblastomaGenotype-targeted therapyBLIMouseAmi HTX1,2-Giovanni Traverso, and 3-Daniel P. Cahill, 1-Massachusetts Institute of Technology, Cambridge, MA, USA, 2-Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, and 3-Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA2018Genotype-targeted therapy of low grade gliomas: Given that most low grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) or IDH2 mutations, they are sensitive to metabolism-altering agents. Developed and tested an intraoperative treatment that coupled both a rapid multiplexed genotyping for IDH mutant gliomas (by qPCR following resection) with, if positive, a sustained release of IDH-directed nicotinamide phosphoribosyltransferase (NAMPT) inhibitor from loaded microparticles (MPs) as a locally toxic therapy, Probe: luciferasecancer glioblastomagenotype-targeted-therapy
Schüler, E., et. al., Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. International Journal of Radiation Oncology, Biology, Physics, 2017, 97(1), 195–203.Cancer, Radiation Oncologyprotocol development, Ultra-high dose rate irradiation (>50 Gy/s “FLASH”)XRAYMouseAmi HTXPeter G. Maxim, Stanford University School of Medicine, Stanford, CA, USA2017New radiation therapy technique with potentially minimal normal tissue toxicity: Protocol development of ultra-high dose rate irradiation (>50 Gy/s, “FLASH”) electron small animal irradiation with a clinically available linear accelerator (LINAC), Probe: none, X-ray imagingcancer radiation-oncologyprotocol-development ultra-high-dose-rate-irradiation-50-gy-s-flash
Samykutty, A., et. al., Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging. Biotech Histochemistry, 2018, 93(8), 608-614.Breast Cancer, CancerDetection and monitoring of breast cancer by a osteopontin-NIR fluorophore conjugateFLIMouseAmi HTLacey R. McNally, Wake Forest School of Medicine, Winston-Salem, NC, USA2018Breast cancer detection and monitoring: Use of a osteopontin-NIR fluorophore conjugate. Multispectral optoacoustic tomography (MSOT), confirmed by NIRF imaging, confirmed probe's in vivo specificity for breast tumor in mouse model , Probe: Hilyte 750 succinyl ester dye breast-cancer cancerdetection-and-monitoring-of-breast-cancer-by-a-osteopontin-nir-fluorophore-conjugate
Rice, M.A., et. al., Loss of Notch1 activity inhibits prostate cancer growth and metastasis and sensitizes prostate cancer cells to antiandrogen therapies. Molecular Cancer Therapeutics, 2019, 18(7): 1230–1242.Cancer, Prostate CancerNOTCH1 and Notch1 activity as therapeutic targets of aggressive prostate cancerBLIMouseLagoTanya Stoyanova, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, USA2019Prostate cancer: Notch1 as a therapeutic target: Loss of NOTCH1 in aggressive prostate cancer led to decreases in proliferation, invasion, tumorsphere formation, and metastatic potential. Inhibitors of Notch1 activity by Gamma secretase inhibitors RO4929097or DAPT further reduced prostate tumor cell proliferation. Loss of NOTCH1 combined with inhibitor therapies could delay development of castration-resistant prostate cancer (CRPC) and metastic events., Probe: luciferasecancer prostate-cancernotch1-and-notch1-activity-as-therapeutic-targets-of-aggressive-prostate-cancer
Qiu, X.Y., et. al., PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. BBA – Molecular Basis of Disease, 2018, 1864: 1754-1769Cancer, GlioblastomaProgrammed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme malignancyFLIMouseLago XXiao Qian Chen, Huazhong University of Science and Technology, Wuhan, China2018Programmed cell death ligand-1 (PD-L1) expression level correlated with glioblastoma multiforme maligency: PD-L1 binding to intracellular Ras leads to enhanced GBM malignancy via activating Ras-Erk-EMT (epithelial mesenchymal transition) axis signaling. 1. And PD-L1 knockdown (by lentiviral infection (LV-sh-PD-L1, with EGFP tag)) abolished GBM development, Probe: eGFPcancer glioblastomaprogrammed-cell-death-ligand-1-pd-l1-expression-level-correlated-with-glioblastoma-multiforme-malignancy
Phuong, P.T.T., et. al., Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy. Colloids and Surfaces B: Biointerfaces, 2018, 171: 123-133.Breast Cancer, CancerBreast tumor ablation by photodynamic therapyFLIMouseLago XBeom Soo Shina, and Yu Seok Youn, Sungkyunkwan University, Suwon, Republic of Korea2018Breast tumor ablation by photodynamic therapy: Chlorin e6 (Ce6) used as a 2nd generation photosynthesizer therapeutic and fluorophore probe, and Ce6 water solubility was improved with "nab" (nanoparticle albumin-bound) technology, including beta-carotene as a cross-linker in the final, loaded albumin NPs, Ce6-BSA-BC-NPs, which showed efficacy vs 4T1 breast tumor xenografts following 660 nm laser irradiation in a mouse model, Probe Ce6breast-cancer cancerbreast-tumor-ablation-by-photodynamic-therapy
Park, S.B., et. al., Bioluminescence imaging of matrix metalloproteinases-2 and -9 activities in ethanol-injured cornea of mice. In vivo, 2021, 35: 1521-1528.Eye Corneal Injury and HealingNon-invasive monitoring eye corneal injury and healingFLIMouseAmi HTXKyung-Jong Won, Konkuk University School of Medicine, Seoul, Republic of Korea2021Non-invasive monitoring eye corneal injury and healing: following 20% ethanol treatment, the extent of eye (corneal epithelial) apoptosis and inflammation was assessed by matrix metalloproteinases (MMP)-2 and MMP-9 activation and activity, as indicated by fluorescence signal intensity of activatable probe NpFlamma® MMP-2/9; eye drops (hyaluronic acid and serum) efficacy was noted by a reduction in NpFlamma® MMP-2/9 signal, Probe: NpFlamma® MMP-2/9eye-corneal-injury-and-healingnon-invasive-monitoring-eye-corneal-injury-and-healing
Park, S., et. al., Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation. Journal of Controlled Release, 2019, 304: 7-18.Cancer, Colon CancerTumor Detection and Ablation by hybrid gold nanoclusters (AuNCs)FLIMouseLago XYu Seok Youn, Sungkyunkwan University, Suwon, Republic of Korea2019Tumor Detection and Ablation by hybrid gold nanoclusters (AuNC): Smaller AuNC (<1-2 nm) allow Cy5.5 fluorescence, Larger AuNC (several nm in size) are good hyperthermic agents. Together, as a hybrid population of AuNCs, with albumin (AuNCs/BSA-NPs), tumor specific uptake, detection, and ablation (by laser therapy) is achieved in a colon cancer model, Probe: Cy 5.5cancer colon-cancertumor-detection-and-ablation-by-hybrid-gold-nanoclusters-auncs
Park, J., et. al., Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceuticals, 2019 May, 16(5): 1864-1873.Breast Cancer, CancerImproving NP delivery to tumor micro environment (TME)FLIMouseAmi HTYoon Yeo, Purdue University, West Lafayette, IN , USA 2019Primary tumor pretreatment with iron-oxide Nanoparticles: Facilitate penetration into the tumor microenvironment (TME), without elevating occurrences of metastases, by the timely application of paclitaxel (PTX)-loaded iron oxide decorated poly(lactic-co-glycolic acid) nanoparticle composite (PTX@PINC) along with an external magnet, prior to secondary NP treatment, Probe: DiRbreast-cancer cancerimproving-np-delivery-to-tumor-micro-environment-tme
Pandurangi, R.S., et. al., A priori activation of apoptosis pathways of tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment, PLoS ONE, 2021, 16(2).Cancer, variousA priori activation of apoptosis pathways of tumor technology (AAAPT)BLIMouseLagoRaghu S. Pandurangi, Sci-Engi-Medco Solutions Inc., St Charles, Missouri, USA2021A priori activation of apoptosis pathways of tumor technology (AAAPT): to activate specific cell death pathways and inhibit survival pathways, simultaneously, and to act selectively in cancer cells sparing normal cells. Tested novel therapeutic AMP-001-003 vs. MDA-MB-231 (triple negative breast cancer), PC3 (prostate cancer) and A543 (lung cancer) cells, Probe: luciferasecancer variousa-priori-activation-of-apoptosis-pathways-of-tumor-technology-aaapt
Padi, S.K.R., et. al., Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Cancer Research, 2017, 77(s13): 5820–5820.Cancer, T-cell Acute Lymphoblastic Leukemiaspan-PIM Protein Kinase Inhibitor and Ponatinib vs.T-cell acute lymphoblastic leukemia subgroupBLIMouseLago XAndrew S. Kraft, University of Arizona, Tucson, AZ, USA2017T-cell acute lymphoblastic leukemia: Treatment by pan-PIM protein kinase inhibitors vs. T-cell acute lymphoblastic leukemia (T-ALL) subset, early T-cell precursors (ETPs) with elevated PIM1 expression (and no NOTCH mutation), and combinatorial treatment with Ponatinib, a broadly active tyrosine kinase inhibitor, led to significantly better efficacy, Probe: luciferasecancer t-cell-acute-lymphoblastic-leukemiaspan-pim-protein-kinase-inhibitor-and-ponatinib-vs-t-cell-acute-lymphoblastic-leukemia-subgroup
O’Leary, M.P., et. al., Novel oncolytic chemeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose. Journal of Translational Medicine, 2018, 16:110.Cancer, Pancreatic CancerOncolytic viral therapy vs. Pancreatic CancerBLIMouseLago XNanhai G. Chen, City of Hope National Medical Center, Duarte, CA, USA2018Oncolytic Chimeric Orthopoxvirus: Recombinant virus encoding firefly luciferase, CF33-Fluc, specific uptake, replication in, and lysis of pancreatic tumors in PANC-1 and MIA PaCa-2 xenograft models., Probe: luciferasecancer pancreatic-canceroncolytic-viral-therapy-vs-pancreatic-cancer
O’Leary, M.P., et. al., A novel oncolytic chimeric orthopoxvirus encoding luciferase enable real-time view of colorectal cancer cell infection. Molecular Therapy Oncolytics, June 2018, 9: 13-21.Cancer, Colorectal CancerOncolytic viral therapy vs. Colorectal CancerBLIMouseLago XNanhai G. Chen, City of Hope National Medical Center, Duarte, CA, USA2018Oncolytic Chimeric Orthopoxvirus: Recombinant virus encoding firefly luciferase, CF33-Fluc, specific uptake, replication in, and lysis of HCT-116 colorectal tumor xenograft in mouse model., Probe: luciferasecancer colorectal-canceroncolytic-viral-therapy-vs-colorectal-cancer
O’Leary, B.R., et. al., Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Nature Research Scientific Reports, 2020, 10: 17649Cancer, Pancreatic CancerPharmacological ascorbate treatment of pancreatic ductal adenocarcinoma (PDAC)BLIMouseAmi HTXJoseph J. Cullen, and Michael D. Henry, University of Iowa, Iowa City, IA, USA2020Pharmacological ascorbate (high-dose, intravenous vitamin C): cytotoxic specifically to pancreatic ductal adenocarcinoma (PDAC), it prevents PDAC metastases by inducing oxidative stress specifically in PDAC cells, not in normal somatic cells; mechanism: hydrogen peroxide production by auto oxidation of pharmacological ascorbate; observed a reduction in circulating tumor cell (CTC) nucleases following ascorbate treatment , Probe: luciferasecancer pancreatic-cancerpharmacological-ascorbate-treatment-of-pancreatic-ductal-adenocarcinoma-pdac
O’Leary, B.R., et. al., Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma, AARC, Clinical Cancer Research, January 29, 2015.Cancer, Pancreatic CancerExtracellular Superoxide Dismutase (SOD) as therapeutic target for treatment of pancreatic adenocarcinoma (PDA)BLIMouseAmi HTJames J. Mezhir, University of Iowa, Iowa City, IA, USA2015Pancreatic ductal adenocarcinoma (PDA): cells lines overexpressing extracellular superoxide dismutase (EcSOD) demonstrated slower growth rates, and loss of EcSOD leading to increase in superoxide and nitric oxide interaction, lead to invasive phenotype supporting aggressive and refractory nature of PDA; treatment with SOD mimetics could be clinically effective vs. PDA, Probe: luciferasecancer pancreatic-cancerextracellular-superoxide-dismutase-sod-as-therapeutic-target-for-treatment-of-pancreatic-adenocarcinoma-pda
Nishihara, R., et. al., Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo. Theranostics, 2019, 9(9): 2646-2661.Breast Cancer, CancerNIR-BRET probes for in vivo monitoring of tumor metastases, protein-protein interactionsBLI,FLI,BRETMouseLagoKoji Suzuki, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan 2019Bright and stable NIR-BRET in vivo probe: Emission peak of coelenterazine (CTZ) derivatives tuned to Soret band (blue light absorption peak) of iRFP, this NIR-BRET conjugate, encoded in mammalian plasmid, was expressed in human breast cancer (MDA-MB231) cells, and detection of cells was evaluated in mouse in model, NIR-BRET probe to be used for detection of metastases and protein-protein interactions, Probes: coelenterazine derivative (RLuc8.6-535SG) combined with iRFPbreast-cancer cancernir-bret-probes-for-in-vivo-monitoring-of-tumor-metastases protein-protein-interactions
Moose, D.L., et. al., Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Reports, 2020, 30: 1-11.Cancer, Prostate CancerMechanism of Resilience of circulating tumor cells (CTCs)BLIMouseAmi HTXMichael D. Henry,University of Iowa, Iowa City, IA, USA2020Resilience of circulating tumor cells (CTCs): exhibit a mechano-adaptive response to fluid shear stress, involves activation of RhoA-actomyosin signaling axis, this signalling is shown to support intravascular survival of CTCs, Probe: luciferasecancer prostate-cancermechanism-of-resilience-of-circulating-tumor-cells-ctcs
Meng, F., et. al., Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited, ACS Nano, 2018, July 24, 12(7): 6458-6468.Fluorescence ImagingFluorescence signal quenching in fluorophore-loaded nanoparticlesFLIMouseAmi HTYoon Yeo, Purdue University, West Lafayette, IN , USA 2018Fluorescence signal quenching in nanoparticles (NPs) loaded with fluorophore: DiR-loaded poly(lactic-co-glycolic acid) (PLGA) NPs show inverse correlation between DiR concentration/NP and signal strength, Probe: DiRfluorescence-imagingfluorescence-signal-quenching-in-fluorophore-loaded-nanoparticles
Marecic, O., et al., Identification and characterization of an injury-induced skeletal progenitor. Proceedings of the National Academy of Sciences, 2015, 112(32): 9920–9925.Bone Growth, Repaircartilage, Distinct gene expression and phenotype of fracture-induced bone, stromal progenitor (f-BCSP) cellsXRAYMouseAmi HTXIrving L. Weissman, Charles K. F. Chan, and Michael T. Longaker, Stanford University School of Medicine, Stanford, CA, USA2015Fracture-induced bone, cartilage, stromal progenitor (f-BCSP) cells: Gene expression pattern and phenotype are similar to that in perinatal skeletogenesis, but distinct from BCSP cells from uninjured bone, f-BCSP cells may be functionally stratified, containing distinct subsets responsible for growth, regeneration, and repair, Probe: none, X-ray imagingbone-growth repaircartilage distinct-gene-expression-and-phenotype-of-fracture-induced-bone stromal-progenitor-f-bcsp-cells
Marchal, M.A., et. al., Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis. bioRxiv, 2020.Cancer, Prostate CancerMetastatic castration-resistant prostate cancer (mCRPC)BLIMouseAmi HTMichael D. Henry, Christopher S. Stip, University of Iowa, Iowa City, IA, USA2020Prostate Cancer: metastatic castration resistant prostatic cancer, Alb deficient cell line showed elevated growth rate associated with AKT pathway activation, Abl kinase inhibitor mimicked Alb deficient cells, inhibitor of AKT pathway reduced tumor growth rate, Probe: luciferasecancer prostate-cancermetastatic-castration-resistant-prostate-cancer-mcrpc
Lucero-Acuña A., et. al., Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer. International Journal of Nanomedicine, 2014,1: 5653–5665.Cancer, Pancreatic CancerOvercoming Severe DesmoplasiaBLIMouseAmi HTEmmanuelle J. Meuillet, University of Arizona, Tucson, AZ, USA2014Pancreatic Cancer Desmoplasia: Severe in pancreatic cancer cell strains with K-Ras mutation, improve therapeutic delivery (e.g. PH-427) by poly (lactic-co-glycolic acid) nanoparticles (PNP), Probe: luciferasecancer pancreatic-cancerovercoming-severe-desmoplasia
Liu, M., et. al., Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Journal of immunology (Baltimore, Md. : 1950), 2015, 195(10): 5055–5065.Cancer, Lung cancerM2 to M1 activated macrophage conversionDual FLIMouseAmi HTJun Yan, University of Louisville, Louisville, KY, USA2015Lung Cancer: Immunosuppressive M2 tumor associated macrophages (TAMs) and bone marrow derived macrophages (BMMs) converted to M1 tumoridical MOs by B-glucan treatment, Probes: XenoLight DiR and VivoTrack 680cancer lung-cancerm2-to-m1-activated-macrophage-conversion
Ling, Q., et. al., The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget, 2017, 8(9): 15159–15167.Cancer, PancreaticAssociated miRNA expression on PDAC recurrence, Prognostic relevance of primary PDAC locationBLIMouseAmi HT1-Holger Kalthoff, and 2,3-Shusen Zheng, 1-Comprehensive Cancer Center North, CAU, Kiel, Germany, 2-College of Medicine, Zhejiang University, Hangzhou, China, and 3-Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, China2017Pancreatic ductal adenocarcinoma (PDAC): Recurrence rates of PDAC following early stage resection appear, by clinical data, to be a function primary PDAC location, with body/tail cancer being a less malignant phenotype than head cancer; deregulation (elevated) expression of miRNA (miR-501-3p) promotes PDAC recurrence and metastases, Probe: luciferasecancer pancreaticassociated-mirna-expression-on-pdac-recurrence prognostic-relevance-of-primary-pdac-location
Li, Y., et. al., Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice. Journal of Immunology, 2015, 194(3): 1011-1020.Cancer, LymphomaGVHD prevention and GVT preservation by helminth injection associated induction of TregsBLIMouseAmi HTM. Nedim Ince, University of Iowa, Iowa City, IA, USA2015Graft vs. Host Disease (GVHD) prevention and Graft vs. Tumor (GVT) immunity preservation: achieved with helminth, H. polygyrus oral injection, leading to activation of regulatory T cells (Tregs) that modulate effector T cell associated intestinal inflammation, and any intestinal bowel disease (IBD), B cell lymphoma burden tracked by Luciferase-expressing A20 (A20-luc) lymphoma cells, Probe: luciferasecancer lymphomagvhd-prevention-and-gvt-preservation-by-helminth-injection-associated-induction-of-tregs
Li, S., et. al., Near infrared fluorescent imaging of brain tumor with !R780 dye incorporated phospholipid nanoparticles, Journal of Translational Medicine, 2017, 15:18Cancer, GlioblastomaImage guided oncological surgery, Tumor DetectionFLIMouseAmi HT1-Shihong Li, and 1,2-Qian Xie, 1-Van Andel Research Institute, Grand Rapids, MI, USA, and 2-East Tennessee State University, Johnson City, USA2017Glioblastoma tracking: Phospholipid micelle and liposome NPs used to deliver NIR fluorescent probe IR780 through blood brain barrier, for accumulation in orthotopic glioblastoma cells by EPR effect, Probe: IR780cancer glioblastomaimage-guided-oncological-surgery tumor-detection
Lee, S.Y., et. al., Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma. Biomaterials Science, 2019.Cancer, Lung cancerNanoparticle drug delivery optimizationFLIMouseAmi HTHyun-Jeong Ko, and Hyun-Jong Cho, Kangwon National University, Chuncheon, Republic of Korea2019Lung adenocarcinoma treatment: Biocompatible, biodegradable, hyaluronic acid (HA), a disaccharide, along with 4-phenylbutyric acid (PBA), with hydrophobic and hydrophilic moieties, used to build PBAHA NPs for loading curcumin (CUR), HA binding to CD44 and CD168 used as active tumor targeting, combined antitumor activities of PBA and CUR tested, NPs tracked with Cy 5.5, Probe: Cy5.5cancer lung-cancernanoparticle-drug-delivery-optimization
Lee, S.Y., et. al., An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy. Drug Delivery, 2018, 25(1): 738-749.Breast Cancer, CancerNanoparticle enzyme-based therapeuticFLIMouseLagoHyun-Jong Cho, Kangwon National University, Chuncheon, Republic of Korea2018Breast Cancer treatment: enzyme-based nanocarrier therapeutic, nano assembly (NA) of D-a-tocopherol succinate conjugated to lysozyme enzyme, loaded with curcumin, tumor specificity is passive by enhanced permeability and retention (EPR) effect, reduced tumor growth, induced apoptosis via mitochondrial destabilization, Probe: Cy5.5breast-cancer cancernanoparticle-enzyme-based-therapeutic
Lee, S.Y., et. al., Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the bloodstream and improved lung targeting efficiency. Journal of Colloid and Interface Science, 2016, 480: 102–108.Cancer, Lung cancerNanoparticle drug delivery optimizationFLIMouseLago X1-In-Soo Yoon, and 2-Hyun-Jong Cho, 1-Mokpo National University, Jeonnam, Republic of Korea, and 2-Kangwon National University, Chuncheon, Republic of Korea2016Lung Cancer: Optimized drug delivery: use of vascular, transient aggregation of chitosan-modified poly(D,L-lactic-co-glycolic) acid nanoparticles,CS-coated PLGA NPs, Probe: Cy5.5cancer lung-cancernanoparticle-drug-delivery-optimization
Lee, J.J., et. al., Predictive modeling of in vivo response to gemcitabine in pancreatic cancer. PLoS Computational Biology, 2013, 9(9).Cancer, Pancreatic CancerPredictive limits of in vitro drug efficacy studiesBLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2013Pancreatic Cancer: predictive modeling of in vivo response to gemcitabine: inefficient vascularization and abundant stroma of tumor microenvironment lead to heterogeneous cell proliferation and death, and ensuing poor penetration and efficacy of gemcitabine treatment, Probe: luciferasecancer pancreatic-cancerpredictive-limits-of-in-vitro-drug-efficacy-studies
Lartey, F.M., et. al., Dynamic CT imaging of volumetric changes in pulmonary nodules correlates with physical measurements of stiffness. Radiotherapy Oncology, 2017 February, 122(2): 313-318.Cancer, Lung cancerNon-invasive scanningXRAYRatAmi HTXBilly W. Loo, and Peter G. Maxim, Stanford University School of Medicine, Stanford, CA, USA2017Lung cancer: non-invasive screening, X-ray guided tumor cell injections, pulmonary nodule stiffness or deformability, correlation with pulmonary nodule (PN) volume ratio, technologies used: PN stiffness: Young’s modulus using atomic force microscopy, PN volume ratio: respiratory-gated MicroCT, Probe: None, X-ray imagingcancer lung-cancernon-invasive-scanning
Lahiji, S.F., et. al., Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth, Biomaterials, 2018.Androgenetic AlopeciaHair regrowth modelFLIMouseLago XHyungil Jung, Yonsei University, Seoul, Republic of Korea2018Hair regrowth: androgenetic alopecia, valproic acid (VPA)-encapsulating dissolving microneedle (DMN-VPA), micro wounding, subdermal, Probe: FITCandrogenetic-alopeciahair-regrowth-model
Kumar, G.D., et. al., Modified coring tool designs reduce iceberg lettuce cross-contamination. Journal of Food Protection, 2019, 82(3): 454–462.Plant PathogensCrop harvestingBLICoring machine, Iceberg LettuceAmi HTSadhana Ravishankar, University of Arizona, Tucson, AZ, USA2019Crop harvesting: Coring tool, minimizing bacterial cross-contamination, food safety, lettuce, Salmonella Newport serotype, Probe: luciferaseplant-pathogenscrop-harvesting
Kimbrough, C.W., et. al., Targeting acidity in pancreatic adenocarcinoma: Multispectral optoacoustic tomography detects pH-low insertion peptide probes in vivo. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2015, 21(20): 4576–4585.Cancer, Pancreatic CancerpH-low insertion peptides as TME-specific probeBLI, FLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2015pH-low insertion peptides (pHLIP): pH-sensitive membrane intercalation, target acidic tumor microenvironment (TME), pancreatic ductal adenocarcinoma, human pancreatic cancer cell line S2VP10, multispectral optoacoustic tomography (MSOT), Probes: HiLyte Fluor 750 C2 maleimide (AnaSpec) conjugated to pH insensitive pHLIP K7 or to ph sensitive pHLIP V7cancer pancreatic-cancerph-low-insertion-peptides-as-tme-specific-probe
Kimbrough, C.W., et. al., Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. Journal of Surgical Research, 2015, 193(1): 246–254.Cancer, Pancreatic CancerFLI and MSOT Detection AssayBLI, FLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2015Localizing orthotopic pancreatic adenocarcinoma: syndecan-1, human pancreatic cancer cell line S2VP10, multispectral optoacoustic tomography (MSOT), ICG as negative control dye, Probes: Syndecan-1, ICG, luciferasecancer pancreatic-cancerfli-and-msot-detection-assay
Ke, B., et. al., In vivo bioluminescence imaging of cobalt accumulation in a mouse model. Analytical Chemistry, 2018, 90: 4946-4950.Cobalt, Trace Element Nutrient TrackingBLI Detection AssayBLIMouseLago XLupei Du and Minyong Li, Shandong University, Jinan, Shandong, China2018Trace element nutrient tracking: Cobalt, Cobalt Bioluminescent Probe 1 (CBP-1), luciferin-cage conjugate , Probe: luciferasecobalt trace-element-nutrient-trackingbli-detection-assay
Kang, Y.Y., et. al., Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain, Phytomedicine, 2019, 62.Central Nervous System, InflammationCombinatorial drug synergistic efficacyFLIMouseLago XHyejung Mok, Konkuk University, Seoul, Republic of Korea2019Byakangelicin enhances the pharmacokinetics (blood brain barrier (BBB) penetration) of various drugs: umbelliferone (Umb), curcumin (Cur), and doxorubicin (Dox), Probe: Green Fluorophorecentral-nervous-system inflammationcombinatorial-drug-synergistic-efficacy
Kaemmer, C.A., et. al., Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis. Nature Portfolio: Scientific Reports, 2021, 11.Cancer, Pancreatic CancerPancreatic neuroendocrine neoplasms (pNENs), preclinical BLI model developmentBLIMouseAmi HTDawn E. Quelle, University of Iowa, Iowa City, IA, USA2021Pancreatic neuroendocrine neoplasms (pNENs): preclinical BLI model development, biodistribution, liver metastases, lung metastases, Probe: luciferasecancer pancreatic-cancerpancreatic-neuroendocrine-neoplasms-pnens preclinical-bli-model-development
Johnson, J., et. al., Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine, 2015, 13(1): 306.Cancer, GlioblastomaGenomic profiling of MET-inhibitor sensitive glioblastoma cell linesBLIMouseAmi HTQian Xie, Van Andel Research Institute, Grand Rapids, MI, USA2015Genetic profiling of MET-inhibitor sensitive glioblastomas: elevated Hepatocyte Growth Factor (HGF) expression correlated with MET-inhibitor efficacy, Probe: luciferasecancer glioblastomagenomic-profiling-of-met-inhibitor-sensitive-glioblastoma-cell-lines
Jeffery, J.J., et. al., Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging. Experimental Biology and Medicine, 2014, 239(4): 404–413.Breast Cancer, CancerBreast cancer bone metastases preventionBLI, uCTMouseAmi HTSetsuko K Chambers, University of Arizona Cancer Center, Tucson, AZ, USA2014Breast Cancer Bone Metastases Prevention: c-fms proto-oncogene, osteolysis, autocrine, polyclonal anti-human c-fms antibody, Probe: luciferasebreast-cancer cancerbreast-cancer-bone-metastases-prevention
Ippen, F.M., et. al., The dual PI3K/mTOR pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases. Clinical Cancer Research: An official journal of the American Association for Cancer Research, 2019, 25(11): 3374–3383.Breast Cancer, CancerBreast cancer brain metastases treatmentBLIMouseAmi HTXPriscilla K. Brastianos, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA2019Breast Cancer Brain Metastases Treatment: GDC-0084, dual PI3K/mTOR inhibitor , Probe: luciferasebreast-cancer cancerbreast-cancer-brain-metastases-treatment
Hudson, S.V., et. al., Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer Research, 2014, 74(21): 6271–6279.Cancer, Pancreatic CancerPancreatic cancer specific NIR fluorescent probeBLI, FLIMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USA2014Pancreatic Cancer: Epidermal growth factor receptor (EGFR), targeted by EGF-CF750 conjugate probe, detected by FLI or multispectral optoacoustic tomography (MSOT), luciferase-transduced S2VP10L tumors, Probes: CF-750, luciferasecancer pancreatic-cancerpancreatic-cancer-specific-nir-fluorescent-probe
Huang, J., et. al., An activatable near-infrared chromophore for multispectral optoacoustic imaging of tumor hypoxia and for tumor inhibition, Theranostics, 2019, 9(24):7313-7324.Cancer, Tumor HypoxiaHypoxia-specific NIR activateable probe conjugated to DNA-binding therapeuticFLIMouseAmi HTFang Zeng, and Shuizhu Wu, South China University of Technology, Guangzhou, China2019Tumor hypoxia: Liposome encapsulated, combined NIR fluorophore probe and DNA-binding therapeutic, nitrogen mustard, are activated by hypoxia-associated reductases , Probe: NR-NH2, an amino-containing xanthene fluorophorecancer tumor-hypoxiahypoxia-specific-nir-activateable-probe-conjugated-to-dna-binding-therapeutic
Huang, D., et. al., Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle. Acta Biomaterialia, 2020.Duchenne muscular dystrophy (DMD)Muscle growth and repairFLIMouseAmi HTFeng Yue, and Shihuan Kuang, Purdue University, West Lafayette, IN , USA 2020Duchenne muscular dystrophy (DMD) treatment: Normalizing muscle growth and repair, phosphatase and tensin homolog (PTEN) inhibitors, nanoparticles (NP), muscle homing peptide, M12, Probe: Alexa Fluor 488duchenne-muscular-dystrophy-dmdmuscle-growth-and-repair
Hipsch, M., et. al., Sensing stress responses in potato with whole-plant redox imaging. Plant Physiology, 2021.Radical Oxygen Species (ROS)Plant Oxidative StressFLIPotato Plant (cv. Desiree)Ami HTShilo Rosenwasser, The Hebrew University of Jerusalem, Rehovot, Israel 2021Radical oxygen species (ROS) production during Environment Stress Conditions: Hydrogen peroxide levels detected by chloroplast associated, glutathione redox potential, in turn, measured by redox sensitive GFP (roGFP2), in Solanum tuberosum potato, environmental stressors tested: temperature, light exposure, drought, Probe: roGFP2radical-oxygen-species-rosplant-oxidative-stress
Heo, R., et. al., Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis, Biomaterials, 2017.Autoimmunity, Rheumatoid ArthritisTherapeutic delivery by NanoparticlesFLIMouseAmi HTJae Hyung Park, Sungkyunkwan University, Suwon, Republic of Korea2017Rheumatoid Arthritis Treatment: dextran sulfate nanoparticles, methotrexate therapeutic, taken up by activated macrophages (via scavenger receptor class A endocytosis) at sites of RA joint inflammation, Probe: FPR-675autoimmunity rheumatoid-arthritistherapeutic-delivery-by-nanoparticles
Henry, M.D., et. al., Comparison of high sensitivity BLI imaging systems for ultra-weak signal applications. (Conference poster).Bioluminescent ImagingSignal calibration across field of view (FOV)BLIMouseAmi HTX1-Michael D. Henry, and 2-Michael D. Cable, 1-University of Iowa Carver College of Medicine, Iowa City, IA, USA, and 2-Spectral Instruments Imaging, Tucson, AZ, USAnaBioluminescent Imaging Devices: normalizing light collection efficiency across FOV, light optics, flat field corrections in Spectral Instruments Imaging vs. IVIS systems, Probe: luciferase bioluminescent-imagingsignal-calibration-across-field-of-view-fov
Hardy, S.D. et. al., Regulation of epithelial-mesenchymal transition and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget, 2017, 8(61): 103302–103314.Breast Cancer, CancerMolecular Biology of Epithelial Mesenchymal transition (EMT)BLIMouseAmi HTMichael K. Wendt and Robert L. Geahlen, Purdue University, West Lafayette, IN , USA 2017Breast Cancer: Processing bodies (P-bodies), stress associated post-transcriptional mRNA metabolism, cleared by autophagy, but accumulates with expression of transforming growth factor-beta (TGF-β) leading to epithelial-mesenchymal transition (EMT), DDX6 inhibition blocks P-body formation and EMT, Probe: luciferase breast-cancer cancermolecular-biology-of-epithelial-mesenchymal-transition-emt
Han, N., et. al., Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics, 2017, 14(5): 1538–1547.Nanoparticle delivery systemsNP targeting of tumor microenvironment (TME)FLIMouseAmi HTYoon Yeo, Purdue University, West Lafayette, IN , USA 2017Tumor targeting Nanoparticles (NPs): coated with amidated TAT peptides, accumulate in acidic tumor microenvironment (TME), due to TAT carboxy residue formation ("activation"), mouse in vivo studies fail due to premature activation not seen in vitro, Probe: DiRnanoparticle-delivery-systemsnp-targeting-of-tumor-microenvironment-tme
Haber, Z., et. al., Resolving diurnal dynamics of the chloroplastic glutathione redox state in Arabidopsis reveals its photosynthetically-derived oxidation, The Plant Cell, 2021.Radical Oxygen Species (ROS)Plant Oxidative StressFLIArabidopsisAmi HTShilo Rosenwasser, The Hebrew University of Jerusalem, Rehovot, Israel 2021Plant oxidative stress: ROS, chloroplastic glutathione redox potential (chl-EGSH), light-dark, dark-light transitions, protection of photosystem I (PSI) and phoytosystem II PSII) from photoinhibition, Probe: roGFP2radical-oxygen-species-rosplant-oxidative-stress
Feng, X., et. al., Responsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals. Chemistry, An Asian Journal, 2018, 10.1002/asia.201800957Radical Oxygen Species (ROS)ROS detection by fluorescence imagingFLIZebra Fish; MouseAmi HT1-Qingtao Meng, and 2-Run Zhang, 1-University of Science and Technology, Liaoning, Anshan, China and 2-The University of Queensland, Brisbane, Australia.2018Reactive Oxygen Species (ROS) Detection: HOCl detection, zebra and mouse models, novel fluorophore, Probe: PQIradical-oxygen-species-rosros-detection-by-fluorescence-imaging
Feng, X., et. al., Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters, 2017, 385: 12–20.Cancer, Glioblastomare-angiogenesis, Tumor recurrenceBLIIn vitro; MouseAmi HTX1-Chuan-Yuan Li, 2-Ling Tian, and 2-Qian Huang, 1-Duke University Medical Center, Durham, NC, USA, and 2-Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China2017Glioblastoma: Tumor recurrence, re-angiogenesis, Caspase 3 dependent, molecular mechanisms, COX-2/PGE2, VEGF-A, Probe: luciferasecancer glioblastomare-angiogenesis tumor-recurrence
Fan, Q., et. al., Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy, Journal of Controlled Release, 2019, 302: 63-78.Cancer, SarcomaTumor vascular normalizationFLIMouseLago XJingqiu Cheng, and Xiaofeng Lu, West China Hospital, Sichuan University, Chengdu, China2019Sarcoma: tumor vascular normalization, cancer-targeted therapy, pericytes, TNFα, affibody, doxorubicin, Probe: CF-750 succinimidyl estercancer sarcomatumor-vascular-normalization
England, C.G., et. al., Detection of phosphatidylcholine-coated gold nanoparticles in orthotopic pancreatic adenocarcinoma using hyperspectral imaging. PloS one, 2015, 10(6).Cancer, Pancreatic CancerNanoparticle intra-tumoral penetrationBLIMouseAmi HTXHermann B. Frieboes, University of Louisville, Louisville, KY, USA2015Gold Nanoparticle (NP) Intratumoral Transport Barriers: interstitial fluid pressure (IFP), chaotic and dense extracellular matrix, acidic micro-environment in orthotopic pancreatic adenocarcinoma (PAC). Penetration improved by: reduced NP size, phosphatidylcholine-coating (vs. PEG coating); detection by hyperspectral imaging, Probe: luciferasecancer pancreatic-cancernanoparticle-intra-tumoral-penetration
England, C.G., et. al., X-ray skeleton imaging in conjunction with bioluminescence imaging does not alter pancreatic tumor. (Conference poster).XRAY ImagingAnimal safety, OncogenesisBLI, XRAYMouseAmi HTXLacey R. McNally, University of Louisville, Louisville, KY, USAnaSafety of in vivo X-Ray Imaging: Oncogenesis, Pancreatic Cancer, Probe: luciferasexray-imaginganimal-safety oncogenesis
Elattar, S., et. al., The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. The FASEB Journal, 2018, 32: 4727–4743.CachexiaCachexia molecular, therapeutic targetFLIMouseAmi HTAnde Satyanarayana, Augusta University, Augusta, Georgia, USA2018Cachexia: tissue-wasting syndrome characterized by inflammation, hyper metabolism, increased energy expenditure, and anorexia. Zinc-α2-glycoprotein (ZAG) as a therapeutic target, beige adipocyte, Ebf2, Prdm16, Ucp1, Probe: Td-Tomatocachexiacachexia-molecular therapeutic-target
Dykstra, M., et. al., In vitro and in vivo studies of cerenkov luminescence imaging. (Conference poster).Cerenkov ImagingCerenkov Imaging with Optical ImagerBLIMouseAmi HTMichael Dykstra, Grand Valley State University, Allendale, MI, USA, and Van Andel Research Institute,Grand Rapids, MI, USAnaCerenkov Luminescence Imaging: positron, positron emission tomography (PET), Probe: 18F-FDGcerenkov-imagingcerenkov-imaging-with-optical-imager
Dassie, J.P., et. al., Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular Therapy, 2014, 22(11): 1910–1922.Cancer, Pancreatic CancerMetastases InhibitionBLI, FLIMouseAmi HTPaloma H. Giangrande, University of Iowa, Iowa City, IA, USA2014Pancreatic Cancer, bone metastases: Tumor-targeting smart drugs, RNA Aptamer (A9g), inhibitor of prostate-specific membrane antigen (PSMA), Probes: luciferase, IRDye 800CWcancer pancreatic-cancermetastases-inhibition
Dann, T., et. al., Anatase titanium dioxide imparts photoluminescent properties to PA2200 commercial 3D printing material to generate complex optical imaging phantoms. Materials, 2021, 14(7): 1813.Imaging PhantomsPhotoluminescent 3D-print phantomsPLOptical PhantomsAmi HTW. Matthew Leevy, University of Notre Dame, 1234 N Notre Dame Avenue, South Bend, IN, USA2021Optical Imaging Phantoms: Selective laser sintering, 3D-printed, nylon 12 and titanium dioxide (TiO2), photoluminescence, rat anatomical phantom, derenzo phantom, Probe: TiO2imaging-phantomsphotoluminescent-3d-print-phantoms
Connolly, R.J., et. al., Development of a catheter-based applicator for immuno-oncology. (Conference Poster).Cancer, MelanomaImmunotherapyBLIMouseLagoRobert H. Pierce, OncoSec Medical Incorporated, San Diego, CA, USAnaMelanoma: Immuno-oncology, immunotherapy, electroporation, catheter, intratumoral delivery of cytokine encoding plasmids, IL-12, Probe: luciferasecancer melanomaimmunotherapy
Chaurasiya, S., et. al., Toward comprehensive imaging of oncolytic viroimmunotherapy, Molecular Therapy: Oncolytics, 2021variousViral oncolytic therapyBLIvariousLago XSusanne Warner, City of Hope National Medical Center, Duarte, CA, USA2021Viral Oncolytic Therapy: tumor micro environment (TME), viroimmunotherapy, Probe: luciferasevariousviral-oncolytic-therapy
Buchakjian, M.R., et al., Development of a Tongue Carcinoma Model Using Real-Time In Vivo Molecular Monitoring. (Conference Poster).Cancer, SarcomaOncogenesisBLIMouseAmi HTXMichael D. Henry, University of Iowa Carver College of Medicine, Iowa City, IA, USAnaTongue Carcinoma: adenovirus CRE recombinase, TP53/PTEN knockout / luc knockin, Probe: luciferasecancer sarcomaoncogenesis
Buchakjian, M.R., et. al., A Trp53 fl/fl Pten fl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PLoS One, 2017, 12(8).Cancer, SarcomaOncogenesisBLIMouseAmi HTXMichael D. Henry and Christopher S. Stipp, University of Iowa Hospitals & Clinics, and University of Iowa Carver College of Medicine, Iowa City, IA,USA2017Sarcoma: adenovirus CRE recombinase, TP53/PTEN knockout / luc knockin, Probe: luciferasecancer sarcomaoncogenesis
Borin, T.F., et. al., HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model. PloS One, 2017, 12(6).Breast Cancer, CancerImmunotherapyBLIMouseAmi HTXAli S. Arbab, Augusta University, Augusta, GA, USA2017Breast Cancer: T41 cells, lung metastases, immunosuppression, myeloid-derived suppressor cells (MDSC), tumor microenvironment (TME), selective inhibitor of 20-HETE synthesis, Probe: luciferasebreast-cancer cancerimmunotherapy
Bhutiani, N., et. al., Detection of microspheres in vivo using multispectral optoacoustic tomography. Biotech Histochemistry, 2017, 92(1): 1–6.Nanoparticles (NPs)NIRF labeling of NPsFLIMouseAmi HTLacey R. McNally, University of Louisville, Louisville, KY, USA2017Microsphere particle delivery system: liver, optoacoustic tomography, Probe: IR-780-iodidenanoparticles-npsnirf-labeling-of-nps
Bahrami, A.J., et. al., A novel approach for endoscopic gene transfer. (Conference Poster), 2017.Cancer, MelanomaImmunotherapyBLIMouseLagoRobert H. Pierce,OncoSec Medical Incorporated, San Diego, CA, USA2017Melanoma: intratumoral gene therapy, electroporation, IL-12, Probe: luciferasecancer melanomaimmunotherapy
Au, K.M., et. al., Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkin’s lymphoma. Science Advances, 2020, 6: 1-12.Cancer, Non-Hodgkin's LymphomaB Cell Receptor transduction cascade regulationFLIMouseAmi HTSteven I. Park, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA2020Non-Hodgkin's Lymphoma (NHL): B Cell receptor transduction cascade, dual PI3K/mTOR inhibitor, delivered by antibody-predirected nanoparticles, , Probe: Cy5cancer non-hodgkins-lymphomab-cell-receptor-transduction-cascade-regulation
Alizadeh, D., et. al., INFɣ is Critical for CAR T cell mediated myeloid activation and induction of endogenous immunity. Cancer Discovery, 2021, 11(9): 2248-2265.Cancer, GlioblastomaImmunotherapyBLIMouseAmi HTChristine E. Brown, City of Hope National Medical Center, Duarte, CA, USA2021Glioblastoma (GBM): chimeric antigen receptor (CAR) T cells, IFNγ, tumor microenvironment, myeloid cells, endogenous memory T cells, Probe: luciferasecancer glioblastomaimmunotherapy
Alizadeh, D., et. al., Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer research, 2014, 74(1): 104–118.Breast Cancer, CancerImmunotherapyBLIMouseAmi HTNicolas Larmonier, University of Arizona, Tucson, Arizona, USA2014Breast Cancer: Myeloid-derived suppressor cells (MDSC), immunotherapy, doxorubicin, Th1, Th17, Probe: luciferasebreast-cancer cancerimmunotherapy
Alexander, M.S., et. al., A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. Journal of Biological Methods, 2018, 5(3): 1-7.Cancer, Pancreatic CancerMetastases formationBLIMouseAmi HTMichael D. Henry, and Joseph J. Cullen, University of Iowa College of Medicine, Iowa City, USA2018Pancreatic ductal adenocarcinoma (PDAC): circulating tumor cells (CTCs), metastasis, orthotopic implantation, Probes: luciferase, GFPcancer pancreatic-cancermetastases-formation
Achyut, B.R., et. al., Chimeric mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments. Cancer Biology & Therapy, 2016, 17(3): 280–290.Cancer, Pancreatic CancerAntiangiogenic resistanceFLIMouseAmi HTAli S. Arbab, Georgia Regents University, Augusta, GA, USA2016Glioblastoma (GBM): tumor antiangiogenic resistance, tumor microenvironment, bone marrow, vascular endothelial growth factor (VEGF), Probe: GFPcancer pancreatic-cancerantiangiogenic-resistance
Achyut, B.R., et. al., Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks. Cancer Letters, 2015, 369(2): 416–426.Cancer, GlioblastomaAntiangiogenic resistanceFLIMouseAmi HTAli S. Arbab, Georgia Regents University, Augusta, GA, USA2015Glioblastoma (GBM): tumor antiangiogenic resistance, tumor microenvironment, bone marrow, vascular endothelial growth factor (VEGF), Probes: GFP, mCherry Redcancer glioblastomaantiangiogenic-resistance

Stay in Touch

Sign up for email updates; we’ll send you tips and tricks for getting better data.

Copyright 2023, Spectral Instruments Imaging © All rights Reserved

All Spectral Instruments Imaging systems are intended for research use only, and are not intended for use in diagnostic procedures.

Thank you for signing up!

Need help with imaging?